|Title||Imaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||DeWitt, W, Chu, K|
|Journal||Physical Review Letters|
Hemeprotein ligand rebinding studies reveal varying IR absorbance and rebinding functions across a cryogenic ensemble. Since IR-active vibrations and rebinding barriers couple to structural coordinates, spectral and functional heterogeneity arise from conformational heterogeneity. Modeling rebinding data as a spectrally resolved superposition of first-order rate processes and employing maximum entropy regularization, protein heterogeneity is imaged as an ensemble occupancy of a spectrum-function phase space. Results from myoglobin rebinding carbon monoxide are discussed.
|Short Title||Phys. Rev. Lett.|
Imaging Protein Statistical Substate Occupancy in a Spectrum-Function Phase Space