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Cilia 2014, :. doi:
2014-01-30T22:18:03+08:00
application/pdf
http://dx.doi.org/
Tyler Picariello
Megan Smith Valentine
Junji Yano
Judith Van Houten
Reduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization
Cilia 2014, :. doi:
Cilia
� 2014 Picariello et al.; licensee BioMed Central Ltd.
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Cilia
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� 2014 Picariello et al.; licensee BioMed Central Ltd.
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reprints@biomedcentral.com
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-0.5099999905 0 0.5102499723 -12.0190000534 re
B*
Q
q
1 0 0 1 56.6930007935 361.1900024414 cm
0 0 m
0.5099999905 0 -0.5102400184 12.0190000534 re
B*
Q
q
1 0 0 1 538.5830078125 361.1900024414 cm
0 0 m
-0.5099999905 0 0.5102499723 -3.0046999454 re
B*
Q
q
1 0 0 1 56.6930007935 358.1860046387 cm
0 0 m
0.5099999905 0 -0.5102400184 3.0046999454 re
B*
Q
q
1 0 0 1 538.5830078125 358.1860046387 cm
0 0 m
-0.5099999905 0 0.5102499723 -11.9619998932 re
B*
Q
q
1 0 0 1 56.6930007935 346.2239990234 cm
0 0 m
0.5099999905 0 -0.5102400184 11.9619998932 re
B*
Q
q
1 0 0 1 538.5830078125 346.2239990234 cm
0 0 m
-0.5099999905 0 0.5102499723 -12.0190000534 re
B*
Q
q
1 0 0 1 56.6930007935 334.2049865723 cm
0 0 m
0.5099999905 0 -0.5102400184 12.0190000534 re
B*
Q
q
1 0 0 1 538.5830078125 334.2049865723 cm
0 0 m
-0.5099999905 0 0.5102499723 -12.0190000534 re
B*
Q
q
1 0 0 1 56.6930007935 322.1860046387 cm
0 0 m
0.5099999905 0 -0.5102400184 12.0190000534 re
B*
Q
q
1 0 0 1 538.5830078125 322.1860046387 cm
0 0 m
-0.5099999905 0 0.5102499723 -11.9619998932 re
B*
Q
q
1 0 0 1 56.6930007935 310.2239990234 cm
0 0 m
0.5099999905 0 -0.5102400184 11.9619998932 re
B*
Q
q
1 0 0 1 538.5830078125 310.2239990234 cm
0 0 m
-0.5099999905 0 0.5102499723 -12.0190000534 re
B*
Q
q
1 0 0 1 56.6930007935 298.2049865723 cm
0 0 m
0.5099999905 0 -0.5102400184 12.0190000534 re
B*
Q
q
1 0 0 1 538.5830078125 298.2049865723 cm
0 0 m
-0.5099999905 0 0.5102499723 -12.0190000534 re
B*
Q
q
1 0 0 1 56.6930007935 286.1860046387 cm
0 0 m
0.5099999905 0 -0.5102400184 12.0190000534 re
B*
Q
q
1 0 0 1 538.5830078125 286.1860046387 cm
0 0 m
-0.5099999905 0 0.5102499723 -11.9619998932 re
B*
Q
q
1 0 0 1 56.6930007935 274.2239990234 cm
0 0 m
0.5099999905 0 -0.5102400184 11.9619998932 re
B*
Q
q
1 0 0 1 538.5830078125 274.2239990234 cm
0 0 m
0 -2.493999958 l
-0.5099999905 -2.493999958 l
-0.5099999905 0 l
B*
Q
q
1 0 0 1 538.5830078125 271.7290039062 cm
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-0.057 -0.7369999886 l
-0.1809999943 -2.1849999428 -1.8400000334 -3.8440001011 -3.2880001068 -3.9690001011 c
-4.0250000954 -4.0250000954 l
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-3.4019999504 -3.4579999447 l
-1.8589999676 -3.1559998989 -0.8690000176 -2.1659998894 -0.5669999719 -0.6240000129 c
-0.5099999905 0 l
B*
Q
q
1 0 0 1 534.5570068359 267.7040100098 cm
0 0 m
-473.8389892578 0 l
-473.8389892578 0.5099999905 l
0 0.5099999905 l
B*
Q
q
1 0 0 1 60.7179985046 267.7040100098 cm
0 0 m
-0.7369999886 0.057 l
-2.2950000763 0.2290000021 -3.7769999504 1.7680000067 -3.9690001011 3.2880001068 c
-4.0250000954 4.0250000954 l
-3.5150001049 4.0250000954 l
-3.4579999447 3.4019999504 l
-3.1559998989 1.8589999676 -2.1670000553 0.8690000176 -0.6240000129 0.5669999719 c
0 0.5099999905 l
B*
Q
q
1 0 0 1 56.6930007935 271.7290039062 cm
0 0 m
0 2.4949998856 l
0.5099999905 2.4949998856 l
0.5099999905 0 l
B*
Q
BT
/F1 1 Tf
13 0 0 13 60.7181015015 690.6895751953 Tm
0 0 0 0 k
0 Tc
0 Tw
[(R) -114.8000030518 (E) -114.4000015259 (S) -118.8000030518 (E) -114.4000015259 (A) -113.8000030518 (R) -119.0999984741 (C) -113.5 (H) -25330.80078125 (Open) -304.200012207 (Access) ] TJ
/F2 1 Tf
22.7999000549 0 0 24.0000991821 56.6929016113 652.7053222656 Tm
0 0 0 1 k
[(Reduction) -303 (of) -301.8999938965 (meckelin) -302.5 (leads) -301.700012207 (to) -300.700012207 (general) -299.8999938965 (loss) -302.3999938965 (of) ] TJ
0 -1.0842000246 TD
[(cilia,) -301.1000061035 (ciliary) -304.799987793 (microtubule) -303.8999938965 (misalignment) -302.5 (and) ] TJ
0 -1.0819000006 TD
[(distorted) -305.5 (cell) -300.799987793 (surface) -302.299987793 (organization) ] TJ
/F3 1 Tf
10.4498996735 0 0 11.0001001358 56.6929016113 576.6801757812 Tm
[(Tyler) -302.5 (Picariello) ] TJ
/F4 1 Tf
7.8372001648 0 0 7.3326997757 116.2204971313 581.6124267578 Tm
<86> Tj
/F3 1 Tf
10.4498996735 0 0 11.0001001358 119.9621963501 576.6801757812 Tm
[(,) -300.6000061035 (Megan) -302.700012207 (Smith) -304 (Valentine) ] TJ
/F4 1 Tf
7.8372001648 0 0 7.3326997757 222.7463989258 581.6124267578 Tm
<86> Tj
/F3 1 Tf
10.4498996735 0 0 11.0001001358 226.5447998047 576.6801757812 Tm
[(,) -300.6000061035 (Junji) -300.3999938965 (Yano) -302.1000061035 (and) -298.3999938965 (Judith) -305.6000061035 (Van) -301.5 (Houten) ] TJ
7.8372001648 0 0 7.3326997757 375.1936035156 581.6124267578 Tm
(*) Tj
/F1 1 Tf
10.3000001907 0 0 10.3000001907 63.212600708 538.1857299805 Tm
(Abstract) Tj
/F5 1 Tf
10.0001001358 0 0 10.0001001358 63.212600708 520.2141113281 Tm
(Background:) Tj
/F3 1 Tf
5.7430000305 0 TD
[(Meckelin) -304.5 (\(MKS3\),) -304.200012207 (a) -301.299987793 (cons) -7.9000000954 (erved) -302.8999938965 (protein) -303.200012207 (linked) -304.299987793 (to) -300.8999938965 (Meckel) -306.5 (Syndrome,) -306.5 (assist) -9 (s) -299.299987793 (i) 0 (n) -298.5 (t) 0 (h) -6.0999999046 (e) -297.700012207 (migration) -307.299987793 (of) ] TJ
-5.7430000305 -1.2019000053 TD
[(centrioles) -303 (to) -300.8999938965 (th) -6.0999999046 (e) -297.700012207 (cell) -300.799987793 (surfac) -11.1000003815 (e) -297.700012207 (for) -301.299987793 (ciliogen) -9.1999998093 (esis.) -301.200012207 (We) -302.1000061035 (explored) -307.1000061035 (for) -301.299987793 (additional) -310.700012207 (functions) -307.200012207 (of) -297.5 (MKS3p) -307.3999938965 (using) -302.200012207 (RNA) -305.8999938965 (interference) ] TJ
T*
[(\(RNAi\)) -303.6000061035 (and) -300.8999938965 (express) -8.6999998093 (ion) -300.3999938965 (of) -303.200012207 (FLAG) -301.799987793 (epitope) -303.6000061035 (tagge) -8.8000001907 (d) -298 (protein) -308.799987793 (in) -298.5 (the) -303.799987793 (ciliated) -305.1000061035 (protozoan) ] TJ
/F6 1 Tf
32.518901825 0 TD
[(P) 20.1000003815 (aramecium) -300.8999938965 (tetra) 10.1999998093 (urelia) ] TJ
/F3 1 Tf
8.9970998764 0 TD
[(.) -298.8999938965 (This) -304.200012207 (cell) -306.3999938965 (has) ] TJ
-41.5159988403 -1.1962000132 TD
[(a) -301.299987793 (highly) -305 (organized) -305 (cell) -306.3999938965 (surface) -303.1000061035 (with) -304.6000061035 (thousands) -308.1000061035 (of) -303.200012207 (cilia) -300.5 (and) -306.5 (basal) -300.3999938965 (bod) -8.3999996185 (ies) -298.299987793 (that) -305.8999938965 (are) -302.3999938965 (grouped) -303.3999938965 (into) -304.6000061035 (one) -301.5 (or) -300.5 (two) -302.8999938965 (basal) ] TJ
0 -1.2019000053 TD
[(body) -302.799987793 (units) -303.1000061035 (delineated) -309.1000061035 (by) -303.299987793 (ridges.) -301.3999938965 (The) -306.5 (highly) -305 (systematized) -306.8999938965 (nature) -304.3999938965 (of) -303.200012207 (the) ] TJ
/F6 1 Tf
28.8337993622 0 TD
[(P.) -301.799987793 (tetra) 10.1999998093 (urelia) ] TJ
/F3 1 Tf
5.113699913 0 TD
[(cell) -300.799987793 (surface) -308.799987793 (provides) -305.799987793 (a) -301.299987793 (research) ] TJ
-33.9474983215 -1.2019000053 TD
[(model) -303.3999938965 (of) -303.200012207 (MKS) -301.299987793 (and) -300.8999938965 (other) -303.799987793 (ciliopat) -9.3999996185 (hies) -300.200012207 (where) -302.700012207 (cha) -8 (nges) -301.700012207 (in) -298.5 (ciliar) -9.5 (y) -300 (structure,) -307.8999938965 (subcellular) -306.799987793 (organiz) -9.6999998093 (ation) -305.3999938965 (and) -300.799987793 (overall) ] TJ
0 -1.1962000132 TD
[(arrangement) -308.6000061035 (of) -303.200012207 (the) -298.1000061035 (cell) -306.3999938965 (surface) -303.1000061035 (can) -302.799987793 (be) -300.8999938965 (easily) -306.200012207 (observed.) -311 (We) -302.1000061035 (used) -301.3999938965 (cells) -305.299987793 (reduced) -306.3999938965 (in) ] TJ
/F6 1 Tf
32.9724006653 0 TD
(IFT88) Tj
/F3 1 Tf
2.2846999168 0 TD
[(for) -301.299987793 (compariso) -10.6999998093 (n,) -300.799987793 (as) -300.200012207 (the) ] TJ
-35.2570991516 -1.2019000053 TD
[(involvement) -308.799987793 (of) -297.5 (this) -307.1000061035 (gene) ] TJ
/F4 1 Tf
10.1140003204 0 TD
<92> Tj
/F3 1 Tf
0.1701000035 0 TD
[(s) -299.299987793 (product) -306.6000061035 (with) -304.6000061035 (cilia) -300.5 (maintenance) -312.299987793 (and) -300.799987793 (growth) -306.200012207 (is) -301.1000061035 (well) -303.200012207 (understood.) ] TJ
/F5 1 Tf
-10.2840003967 -1.4967000484 TD
(Results:) Tj
/F3 1 Tf
3.5943000317 0 TD
[(FLAG-MKS3p) -306.8999938965 (was) -307.8999938965 (found) -304.299987793 (above) -304.6000061035 (the) -298.1000061035 (plane) -305.5 (of) -303.200012207 (the) -303.799987793 (distal) -299.799987793 (bas) -8.6000003815 (al) -297.3999938965 (body) -308.3999938965 (in) -298.5 (the) -303.799987793 (transition) -304.6000061035 (zone.) -307.5 (Approximately) ] TJ
-3.5943000317 -1.2019000053 TD
[(95%) -302.8999938965 (of) -297.5 (those) -304.5 (basal) -306.1000061035 (bodies) -306.700012207 (observed) -306.8999938965 (had) -300.8999938965 (staining) -309.299987793 (for) -301.299987793 (FLAG-MKS3.) -307.700012207 (The) -300.799987793 (RNAi) -307.700012207 (phenotype) -305.200012207 (for) ] TJ
/F6 1 Tf
36.6234016418 0 TD
(MKS3) Tj
/F3 1 Tf
2.4151000977 0 TD
[(deple) -8.3999996185 (ted) -299.3999938965 (cells) ] TJ
-39.0385017395 -1.2019000053 TD
[(included) -305.1000061035 (global) -307.700012207 (shortening) -305.8999938965 (and) -300.8999938965 (loss) -307.5 (of) -297.5 (cilia.) -304.6000061035 (Basal) -307.3999938965 (body) -302.799987793 (structure) -309.5 (appeared) -304.6000061035 (unaffe) -8.8999996185 (cted.) -303.1000061035 (On) -299.700012207 (the) -303.799987793 (dorsal) -305.299987793 (surface,) -307.200012207 (the) ] TJ
0 -1.1962000132 TD
[(basal) -306.1000061035 (bodies) -301.1000061035 (and) -306.5 (their) -303.700012207 (associated) -307.799987793 (rootlets) -302.8999938965 (appeared) -310.299987793 (rotated) -304.5 (out) -302.5 (of) -303.200012207 (alignment) -306.3999938965 (from) -305.700012207 (the) -298.1000061035 (normal) -309.5 (anterior-posterior) ] TJ
0 -1.2019000053 TD
[(rows.) -305.5 (Likewise,) -307.799987793 (cortical) -302.5 (units) -303.1000061035 (were) -306.3999938965 (abnormal) -308 (in) -298.5 (shape) -308.299987793 (and) -300.8999938965 (out) -302.3999938965 (of) -303.200012207 (alignment) -306.3999938965 (from) -305.700012207 (normal) -303.799987793 (rows.) -305.5 (A) -301.3999938965 (GST) -301.200012207 (pull) -303.200012207 (down) ] TJ
T*
[(using) -302.200012207 (the) -303.799987793 (MKS3) -304.200012207 (coiled-coil) -309.1000061035 (domain) -303.299987793 (suggests) -306.5 (previo) -8.8999996185 (usly) -302.200012207 (unidentified) -305.799987793 (intera) -9.6999998093 (cting) -299.799987793 (partn) -8.3000001907 (ers.) ] TJ
/F5 1 Tf
0 -1.4967000484 TD
(Conclusions:) Tj
/F3 1 Tf
5.7088999748 0 TD
[(Reduction) -305.1000061035 (of) -303.200012207 (MKS3p) -307.3999938965 (shows) -304 (that) -300.200012207 (this) -301.5 (pr) -7.0999999046 (otein) -301.799987793 (affects) -302.700012207 (developm) -9.8999996185 (ent) -303.799987793 (and) -300.8999938965 (maintenance) -306.6000061035 (of) -303.200012207 (cilia) -306.200012207 (over) -304.299987793 (the) ] TJ
-5.7088999748 -1.2019000053 TD
[(entire) -300.8999938965 (cell) -300.799987793 (surfac) -11.1000003815 (e.) -301.799987793 (Reduction) -305.1000061035 (of) -303.200012207 (MKS3p) -301.799987793 (is) -301.1000061035 (most) -304.1000061035 (visible) -306 (on) -304.299987793 (the) -298.1000061035 (dorsal) -305.299987793 (surface.) -307.200012207 (The) -306.5 (anterior) -304.6000061035 (basal) -306.1000061035 (body) -302.799987793 (is) -301.1000061035 (attached) -306.799987793 (to) ] TJ
T*
[(and) -300.8999938965 (moves) -303.700012207 (along) -304.5 (the) -303.799987793 (striated) -303.200012207 (roo) -7.5999999046 (tlet) -302.1000061035 (of) -297.5 (the) -303.799987793 (posterior) -305.799987793 (basal) -306.1000061035 (body) -302.799987793 (in) -304.1000061035 (preparation) -306.299987793 (for) -301.299987793 (dup) -8.1000003815 (lication.) -306.8999938965 (We) -302.1000061035 (propose) -305 (that) ] TJ
0 -1.1962000132 TD
[(with) -299 (reduced) -306.3999938965 (M) -6.6999998093 (KS3p,) -299.200012207 (th) -6.0999999046 (is) -301.1000061035 (attachment) -308.299987793 (and) -300.8999938965 (guidance) -309.8999938965 (of) -297.5 (th) -6.0999999046 (e) -297.700012207 (basal) -306.1000061035 (body) -302.799987793 (is) -301.1000061035 (lost.) -305.6000061035 (The) -300.799987793 (basal) -306.1000061035 (body) -302.799987793 (veers) -304.1000061035 (off) -304 (course,) ] TJ
0 -1.2019000053 TD
[(causing) -302.6000061035 (bas) -8.6000003815 (al) -297.3999938965 (body) -308.3999938965 (rows) -301.3999938965 (to) -300.8999938965 (be) -300.8999938965 (misaligned) -309.8999938965 (and) -300.799987793 (units) -308.700012207 (to) -300.8999938965 (be) -300.8999938965 (misshapen.) -307.8999938965 (Rootlets) -303.700012207 (form) -305.700012207 (normally) -305.1000061035 (on) -304.299987793 (these) -299.799987793 (misali) -9.3999996185 (gned) ] TJ
T*
[(basal) -306.1000061035 (bodies) -301.1000061035 (but) -303.799987793 (are) -302.3999938965 (rotated) -304.5 (out) -302.3999938965 (of) -303.200012207 (their) -303.700012207 (correct) -304.799987793 (orientation) -10.1000003815 (.) -298.8999938965 (Our) -303.200012207 (hypothes) -8.8000001907 (is) -301.1000061035 (is) -301.1000061035 (further) -302.3999938965 (suppo) -8.8999996185 (rted) -303.200012207 (by) -303.299987793 (the) ] TJ
0 -1.1962000132 TD
[(identification) -306.299987793 (of) -303.200012207 (novel) -304.200012207 (interacting) -309.5 (partners) -303 (of) -303.200012207 (MKS3p) -307.3999938965 (including) -305.8999938965 (a) -301.299987793 (kinetodes) -9.8000001907 (mal) -301.799987793 (fiber) -301.6000061035 (protein) -8.3999996185 (,) -298.8999938965 (KdB2.) ] TJ
/F1 1 Tf
10.3000001907 0 0 10.3000001907 56.6929016113 243.7227935791 Tm
[(Backgroun) -13.6000003815 (d) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 231.7606048584 Tm
[(Ci) 17.2000007629 (li) 16.7000007629 (op) 15.5 (at) 16.8999996185 (hi) 14.1999998093 (es) -307.700012207 (ar) 12.1000003815 (e) -316.6000061035 (h) 0 (u) 17.5 (m) 0 (a) 13.1000003815 (n) -315.799987793 (di) 15.8000001907 (so) 14.1000003815 (rd) 15.1000003815 (er) 17.8999996185 (s) -315 (c) 0 (a) 14.6999998093 (u) 0 (s) 12 (e) 0 (d) -306.299987793 (b) 0 (y) -311.5 (a) 0 (b) 12.5 (n) 0 (o) 19.1000003815 (r) 0 (m) 16.2999992371 (a) 0 (l) 12.8000001907 (i) 11.1999998093 (ti) 15.1000003815 (es) ] TJ
0 -1.2264000177 TD
[(in) -345 (th) 12.6000003815 (e) -357.1000061035 (ass) 13.6999998093 (em) 13.1000003815 (b) 10.8999996185 (l) 0 (y) 12.8000001907 (,) -354.700012207 (ma) 13.1000003815 (i) 11.1999998093 (n) 0 (t) 12 (e) 0 (n) 15.5 (a) 0 (n) 15.5 (c) 13.1000003815 (e) -357.1000061035 (o) 0 (r) -348.799987793 (f) 0 (u) 16.2999992371 (n) 0 (c) 15.5 (t) 0 (i) 15.1000003815 (o) 0 (n) -351.1000061035 (o) 10.8999996185 (f) -356.8999938965 (c) 0 (i) 12.8000001907 (l) 11.1999998093 (ia) -351.700012207 (an) 15.5 (d) -354.1000061035 (i) 0 (n) 13.6999998093 (-) ] TJ
T*
[(cl) 18.6000003815 (ud) 13.3000001907 (e) -351.299987793 (dev) 12.8999996185 (el) 18.6000003815 (op) 15.5 (me) 13.1000003815 (nt) 17.7999992371 (al) -345.8999938965 (de) 17.7000007629 (fec) 10.6000003815 (ts) -351.700012207 (l) 11.1999998093 (e) 0 (a) 14.6999998093 (d) 0 (i) 15.8000001907 (n) 0 (g) -340.1000061035 (t) 0 (o) -343.8999938965 (c) 0 (y) 14.6999998093 (s) 0 (t) 18.6000003815 (i) 0 (c) -345.8999938965 (k) 0 (i) 19.5 (d) 0 (n) 12.8000001907 (e) 0 (y) 14.6999998093 (s) -8.3999996185 (,) -348.8999938965 (v) 0 (i) 12.1999998093 (-) ] TJ
0 -1.220600009 TD
[(si) 14.3999996185 (o) 10.8999996185 (n) -610.799987793 (pr) 15.1000003815 (o) 10.8999996185 (b) 0 (l) 10.6000003815 (e) 0 (m) 18.8999996185 (s) -14.1999998093 (,) -609.299987793 (p) 0 (o) 15.5 (l) 0 (y) 12.8000001907 (d) 0 (a) 17.7000007629 (c) 0 (t) 16.8999996185 (y) 0 (l) 12.8000001907 (y) 0 (,) -601.9000244141 (o) 10.8999996185 (be) 12.5 (si) 14.3999996185 (ty) 16.8999996185 (,) -609.299987793 (e) 0 (n) 15.5 (c) 0 (e) 14.6999998093 (p) 0 (h) 13.3000001907 (a) 0 (l) 18.6000003815 (o) 0 (c) 12.5 (e) 0 (l) 18.6000003815 (e) -611.700012207 (an) 15.5 (d) ] TJ
0 -1.2264000177 TD
-0.0003 Tc
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T*
0 Tc
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[(rupting) -457.299987793 (this) -453.1000061035 (or) -7.5 (ganiz) -11.8000001907 (ation) -456 (or) -452.8999938965 (de) -17 (velopment) -460.6000061035 (of) -455.8999938965 (these) -467.1000061035 (cor) 17.2000007629 (-) ] TJ
0 -1.2264000177 TD
[(tical) -618.5 (unit) -20 (s) -615.799987793 (causes) -622.4000244141 (growth) -618 (arrest) -622.5 (and) -622 (e) -10 (ven) -619.799987793 (cell) -616.5999755859 (death) ] TJ
T*
0.0001 Tc
[([19,23,24].) -490.5 (It) -484.6000061035 (is) -483 (this) -493.5 (highly) -491.700012207 (repetitive) -492.8999938965 (patt) -9.3000001907 (erned) -488.3999938965 (surfa) -8.8000001907 (ce) ] TJ
0 -1.220600009 TD
0 Tc
[(organiz) -19.2000007629 (ation) -398.200012207 (that) -398.6000061035 (allows) -398.700012207 (identifi) -10 (cation) -396.6000061035 (of) -392.299987793 (subtle) -411.799987793 (chan) -8.8999996185 (ges) ] TJ
0 -1.2264000177 TD
[(in) -304.5 (ciliary) -304 (and) -303.8999938965 (surfa) -8.8999996185 (ce) -303.5 (organiz) -19.2000007629 (ation) -305.6000061035 (in) ] TJ
/F8 1 Tf
15.6079998016 0 TD
[(P.) -301.799987793 (tetraurelia) ] TJ
/F7 1 Tf
5.4842000008 0 TD
(.) Tj
-20.2765007019 -1.2264000177 TD
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-0.8156999946 -1.220600009 TD
[(\(RNA) -8.3999996185 (i\)) -320.5 (to) -326.6000061035 (perturb) -331.1000061035 (the) -333 (ciliopa) -11.3000001907 (thy) -321.3999938965 (pro) -8.6999998093 (tein) -322.299987793 (MKS) -8.6000003815 (3) -321.5 (i) 0 (n) ] TJ
/F8 1 Tf
21.3409996033 0 TD
[(P.) -325 (tet) -10.1999998093 (-) ] TJ
-21.3409996033 -1.2264000177 TD
(raurelia) Tj
/F7 1 Tf
3.6503999233 0 TD
[(presented) -319.200012207 (herein) -316.799987793 (suggest) -317.3999938965 (pre) -12.3000001907 (viously) -316.6000061035 (uniden) -9.5 (tified) ] TJ
-3.6503999233 -1.220600009 TD
[(roles) -402.200012207 (for) -404.8999938965 (this) -401.1000061035 (protein) -406.200012207 (in) -397.1000061035 (main) -8 (taining) -402.3999938965 (the) -413.8999938965 (cell) -402.5 (and) -402.200012207 (ciliary) ] TJ
0 -1.2264000177 TD
[(membra) -10.3000001907 (ne) -343.1000061035 (surfa) -8.8999996185 (ce) -349.799987793 (and) -344.3999938965 (cytosk) -11.1999998093 (eletal) -350.8999938965 (organiz) -19.2000007629 (ation.) -353.700012207 (T) 93.3000030518 (agged) ] TJ
T*
[(MKS3) -440 (protein) -440.8999938965 (is) -431 (con) -8.3000001907 (sistently) -443.8999938965 (found) -440.200012207 (above) -436.8999938965 (the) -437.1000061035 (pl) -7.3000001907 (ane) -434.1000061035 (of) ] TJ
0 -1.220600009 TD
[(the) -483.3999938965 (ba) -16.5 (sal) -481.5 (body,) -483 (in) -483.799987793 (the) -477.6000061035 (transit) -9.6999998093 (ion) -484.5 (zone) -485.299987793 (of) ] TJ
/F8 1 Tf
18.3733005524 0 TD
[(Par) 15.8999996185 (amecium) ] TJ
/F7 1 Tf
5.2701997757 0 TD
(,) Tj
-23.6434001923 -1.2264000177 TD
[(which) -412.299987793 (spans) -407.3999938965 (from) -404.8999938965 (the) -408.200012207 (proximal) -409.799987793 (surface) -410.799987793 (of) -403.8999938965 (the) -408.200012207 (epipla) -17.3999996185 (sm) ] TJ
T*
0.0002 Tc
[(to) -557.799987793 (the) -564.200012207 (cilia) -9.3000001907 (ry) -554.5999755859 (ne) -13.1999998093 (cklace) -558.4000244141 ([25,26].) -559.799987793 (Dawe) -555 (an) -7.4000000954 (d) -550.5999755859 (othe) -9.5 (rs) -553 ([27]) ] TJ
0 -1.220600009 TD
0 Tc
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0 -1.2264000177 TD
[(upon) -384.1000061035 (reducti) -10 (on) -374.299987793 (of) ] TJ
/F8 1 Tf
8.0989999771 0 TD
[(MK) -7.3000001907 (S3) ] TJ
/F7 1 Tf
2.9446001053 0 TD
[(mRN) -8.6999998093 (A) -373.799987793 (l) 0 (e) -16.1000003815 (vels) -23.5 (,) -377.8999938965 (whic) -10.3999996185 (h) -373 (are) -385.5 (simi-) ] TJ
-11.0436000824 -1.2264000177 TD
[(lar) -346.8999938965 (to) -349.700012207 (our) -345.799987793 (finding) -8 (s) -343.8999938965 (o) 0 (f) -346 (short) -350.3999938965 (an) -7.5999999046 (d) -342.5 (missin) -9.3000001907 (g) -342.5 (cilia) -350.799987793 (with) -349.3999938965 (RNAi.) ] TJ
0 -1.220600009 TD
[(Our) -333.6000061035 (stud) -8.6000003815 (y) -328.200012207 (show) -9 (s) -332.299987793 (new) -334.6000061035 (findi) -9.3000001907 (ngs) -18.7000007629 (,) -337.3999938965 (most) -335 (notably) -339.3999938965 (that) -340.700012207 (reduc-) ] TJ
0 -1.2264000177 TD
[(tion) -393.8999938965 (of) ] TJ
/F8 1 Tf
3.2511999607 0 TD
(MKS3) Tj
/F7 1 Tf
2.9561998844 0 TD
[(causes) -396.700012207 (misalig) -9 (nment) -394.799987793 (of) -392.299987793 (longitu) -10.6000003815 (dinal) -391.299987793 (rows) ] TJ
-6.2073001862 -1.2264000177 TD
[(of) -664.200012207 (ba) -16.5 (sal) -637.700012207 (bodies) -27.1000003815 (,) -632.4000244141 (rotat) -9.8999996185 (ion) -634.9000244141 (of) -635.299987793 (the) -639.5999755859 (orientatio) -13 (n) -633.9000244141 (o) 0 (f) -664.200012207 (b) 0 (a) -16.5 (sal) ] TJ
25.3094997406 64.8964004517 TD
[(bodies) -403.1000061035 (with) -395.700012207 (the) -9 (ir) -394.700012207 (microtub) -11.6999998093 (ule) -395 (rootlet) -22.3999996185 (s) -390.200012207 (and) -396.3999938965 (distort) -9.8000001907 (ion) -397.700012207 (of) ] TJ
0 -1.220600009 TD
[(the) -477.6000061035 (cell) -460.3999938965 (an) -7.5999999046 (d) -458.200012207 (cilia) -9.5 (ry) -462.299987793 (surfaces.) -467.299987793 (We) -469.3999938965 (also) -464.799987793 (ha) 10.3000001907 (ve) -466.1000061035 (e) -10 (viden) -8.1999998093 (ce) -459.700012207 (of) ] TJ
0 -1.2264000177 TD
[(new) -427.1000061035 (po) -7.6999998093 (tential) -433 (interactin) -13.5 (g) -423.5 (partners) -436.200012207 (of) -427 (MKS3) -428.3999938965 (rele) -15.6000003815 (vant) -430.8999938965 (to) ] TJ
T*
[(these) -305.1000061035 (microtu) -11.1000003815 (bule) -303.1000061035 (rootlet) -22.3999996185 (s) -20 (,) -302.700012207 (suggesting) -310.6000061035 (important) -309.8999938965 (interac-) ] TJ
0 -1.220600009 TD
[(tions) -471.700012207 (of) -461.700012207 (MKS) -8.6000003815 (3) -460.299987793 (with) -470.8999938965 (these) -467.1000061035 (stru) -8.3999996185 (ctures.) -469.8999938965 (The) -457.6000061035 (depletio) -14.1999998093 (n) -460.3999938965 (o) 0 (f) ] TJ
0 -1.2264000177 TD
[(intraf) -9.1999998093 (lagellar) -305.1000061035 (transpo) -9.3000001907 (rt) -298 (88) -295.8999938965 (\() ] TJ
/F8 1 Tf
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[(IF) -14.8000001907 (T88) ] TJ
/F7 1 Tf
2.5048999786 0 TD
[(\)) -297 (mRNA) -35.4000015259 (,) -296.8999938965 (used) -305.8999938965 (a) -10 (s) -297.6000061035 (a) -299.299987793 (con-) ] TJ
-13.7973003387 -1.2264000177 TD
[(trol) -333.700012207 (to) -332.3999938965 (obser) -38.0999984741 (ve) -333 (global) -337.1000061035 (ciliary) -338.700012207 (loss) -23.5 (,) -331.6000061035 (causes) -338.8999938965 (short) -333 (and) -332.799987793 (miss) -17.2000007629 (-) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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/F8 1 Tf
21.5377006531 0 TD
[(P) 12.3999996185 (ara-) ] TJ
-21.5377006531 -1.2264000177 TD
(mecium) Tj
/F7 1 Tf
3.7718000412 0 TD
[(act) -16.2000007629 (s) -482.799987793 (a) -15.8000001907 (s) -482.799987793 (a) -484.3999938965 (transie) -12 (nt) -485.5 (guide) -489.8999938965 (in) -489.6000061035 (the) -489.200012207 (movemen) -11.6000003815 (t) -482.1000061035 (o) 0 (f) ] TJ
-3.7718000412 -1.220600009 TD
-0.0175000001 Tc
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0 -1.2264000177 TD
-0.0168999992 Tc
[(wi) 5.9000000954 (th) -262.700012207 (the) -264.1000061035 (m) 0.400000006 (icrotub) 5.5999999046 (u) -2.2999999523 (le) -264.1000061035 (r) 5.1999998093 (ootl) 5.9000000954 (e) 2 (t) -279.200012207 (s) 3.5999999046 (ystem) -259.8999938965 (a) -3.7999999523 (nd) -261.1000061035 (that) -261.799987793 (it) -16.8999996185 (s) -252.8999938965 (l) 0.1000000015 (ocaliz) -16.8999996185 (a) 10.8999996185 (t) -1.5 (io) 5.5999999046 (n) ] TJ
T*
0 Tc
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0 -1.220600009 TD
[(at) -255 (th) 18.3999996185 (e) -264.6000061035 (t) 0 (r) 14.3999996185 (a) 0 (n) 15.5 (s) 0 (i) 20.2000007629 (t) 0 (i) 15.1000003815 (o) 0 (n) -258.6000061035 (z) 0 (o) 19.7999992371 (n) 0 (e) -256.3999938965 (a) 0 (s) -267.200012207 (a) -258.799987793 (fi) 13 (l) 11.1999998093 (t) 0 (e) 16.8999996185 (r) 0 (.) ] TJ
/F1 1 Tf
10.3000001907 0 0 10.3000001907 304.7243041992 516.9259033203 Tm
(Methods) Tj
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 504.9637145996 Tm
[(Stocks,) -308.299987793 (cultures) -308.799987793 (and) -300.8999938965 (chemic) -9.8000001907 (als) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 492.9447937012 Tm
[(Cells) -470.200012207 (\(stoc) -11.3999996185 (k) -466.1000061035 (51s) ] TJ
/F8 1 Tf
7.3295998573 0 TD
[(P.) -469.6000061035 (tetraurelia) ] TJ
/F7 1 Tf
5.6693000793 0 TD
[(,) -470.3999938965 (sensit) -9.3000001907 (ive) -466.3999938965 (to) -471.200012207 (killer\)) -474.299987793 (were) ] TJ
-12.9989995956 -1.2264000177 TD
[(grown) -327.3999938965 (in) -316.1000061035 (whe) -10 (at) -318.6000061035 (gra) -18 (ss) -317.6000061035 (mediu) -8.6000003815 (m) -318.200012207 (inoc) -8.6000003815 (ulated) -327.200012207 (with) ] TJ
/F8 1 Tf
19.848400116 0 TD
(Klebsiella) Tj
-19.848400116 -1.220600009 TD
[(pneumo) -11.6000003815 (niae) ] TJ
/F7 1 Tf
5.8544998169 0 TD
(or) Tj
/F8 1 Tf
1.6603000164 0 TD
[(Aerobac) -12.3000001907 (ter) -755.5999755859 (aerogene) -19.2999992371 (s) ] TJ
/F7 1 Tf
9.973400116 0 TD
[(\(adapted) -772.4000244141 (from) ] TJ
-17.4881000519 -1.2264000177 TD
[([28]\).) -457.799987793 (All) -455.5 (chem) -11.3000001907 (icals) -457.200012207 (were) -457.8999938965 (obt) -9.1000003815 (ained) -458.799987793 (from) -457 (Sigma) -10.6999998093 (-Aldrich) ] TJ
T*
[(\(St) -303.799987793 (Loui) -8.6999998093 (s) -20 (,) -302.700012207 (MO,) -301.299987793 (USA\)) -305.3999938965 (unless) -311 (otherwise) -310.1000061035 (noted.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 420.9447937012 Tm
[(Sequence) -309.200012207 (analys) -8 (is) -301.5 (and) -300.8999938965 (construct) -308.299987793 (d) -7.1999998093 (esign) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 408.9259033203 Tm
[(BL) -13.6000003815 (AST) -395.299987793 (se) 16.2999992371 (ar) 17.8999996185 (ch) 16.1000003815 (es) -475.3999938965 (i) 11.1999998093 (n) -477.700012207 (th) 12.6000003815 (e) ] TJ
/F8 1 Tf
10.4014997482 0 TD
-0.0178999994 Tc
[(Pa) -17.8999996185 (r) 8.8000001907 (a) -17.8999996185 (me) -17.8999996185 (c) -5.8000001907 (i) -17.8999996185 (um) ] TJ
/F7 1 Tf
5.6634998322 0 TD
0 Tc
[(an) 15.5 (no) 13.3000001907 (ta) 16.8999996185 (te) 16.8999996185 (d) -481.3999938965 (g) 0 (e) 17.7000007629 (n) 0 (o) 13.3000001907 (m) 11.5 (e) ] TJ
-16.0650005341 -1.220600009 TD
[(we) 15.8999996185 (re) -335 (co) 12.5 (mp) 16.1000003815 (l) 11.1999998093 (e) 0 (t) 11.1999998093 (e) 0 (d) -323.6000061035 (u) 0 (s) 17.7000007629 (i) 0 (n) 13.6999998093 (g) -330.8999938965 (th) 12.6000003815 (e) -334 (h) 0 (u) 17.5 (m) 0 (a) 13.1000003815 (n) -333.1000061035 (se) 16.2999992371 (qu) 13.3000001907 (en) 15.5 (ce) -320.8999938965 (fo) 12.6999998093 (r) ] TJ
/F8 1 Tf
19.8369007111 0 TD
[(TM) 12.1999998093 (E) -22.2999992371 (M) 0 (6) 16 (7) ] TJ
/F7 1 Tf
-19.8369007111 -1.2264000177 TD
[(\(Q) 15.3999996185 (5H) 14.6000003815 (Y) 52.2999992371 (A) 0 (8) 16.2999992371 (\)) -314.3999938965 (fo) 12.6999998093 (r) ] TJ
/F8 1 Tf
6.2305002213 0 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.8519999981 0 TD
[(an) 15.5 (d) -313.6000061035 (t) 0 (h) 18.3999996185 (e) -316.6000061035 (hu) 17.5 (ma) 13.1000003815 (n) ] TJ
/F8 1 Tf
6.6353998184 0 TD
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
2.7767999172 0 TD
[(\(N) 11.8000001907 (P_) 17 (78) 16.5 (31) 16.5 (95) 16.5 (\)) ] TJ
-18.4946994781 -1.2264000177 TD
[(an) 15.5 (d) -683.9000244141 (m) 11.5 (ou) 13.8999996185 (se) ] TJ
/F8 1 Tf
5.5363001823 0 TD
[(T) 50.7000007629 (g) 11.1000003815 (73) 16.5 (7) ] TJ
/F7 1 Tf
3.1586000919 0 TD
[(\(N) 17.6000003815 (P_) 17 (03) 16.5 (34) 16.5 (02) 16.5 (\)) -684.5999755859 (s) 0 (e) 16.2999992371 (q) 0 (u) 13.3000001907 (e) 0 (n) 15.5 (c) 0 (e) 14.6999998093 (s) -679.5 (fo) 12.6999998093 (r) ] TJ
/F8 1 Tf
12.69810009 0 TD
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
-21.392999649 -1.220600009 TD
[(or) 15.6999998093 (th) 18.3999996185 (ol) 10.6000003815 (o) 10.8999996185 (g) 0 (s) 13.6000003815 (.) -389.3999938965 (Se) 14 (ar) 17.8999996185 (ch) 16.1000003815 (es) -382.8999938965 (id) 15.8000001907 (en) 15.5 (ti) 15.1000003815 (fi) 18.7999992371 (ed) -387.299987793 (GS) 16.7999992371 (P) 58.7000007629 (A) 71.6999969482 (TG) 16.6000003815 (00) 16.5 (01) 16.5 (59) 16.5 (39) 16.5 (00) 16.5 (1) -390.8999938965 (a) 0 (s) -394.3999938965 (a) ] TJ
0 -1.2264000177 TD
[(po) 15.5 (te) 16.8999996185 (nt) 12 (i) 11.1999998093 (a) 0 (l) -259.1000061035 (o) 0 (r) 15.6999998093 (t) 0 (h) 12.6000003815 (o) 10.8999996185 (lo) 10.6000003815 (g) -273.1000061035 (f) 0 (o) 12.6999998093 (r) ] TJ
/F8 1 Tf
9.0650997162 0 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.5281000137 0 TD
[(,) -273.700012207 (w) 0 (h) 17.3999996185 (i) 11.1999998093 (ch) -261.6000061035 (was) -264.3999938965 (us) 12 (ed) -260 (to) -262.8999938965 (c) 13.1000003815 (r) 0 (e) 12.1000003815 (a) 0 (t) 16.8999996185 (e) -270.299987793 (th) 18.3999996185 (e) ] TJ
-11.5931997299 -1.2264000177 TD
[(RN) 14.5 (Ai) -258.3999938965 (co) 18.2000007629 (ns) 11.3999996185 (tr) 20.1000003815 (uc) 16.1000003815 (t.) -258.299987793 (Fi) 16.3999996185 (ve) -257.799987793 (po) 15.5 (te) 11.1999998093 (nt) 17.7999992371 (ia) 12.8000001907 (l) -260.700012207 (o) 0 (r) 15.6999998093 (t) 0 (h) 12.6000003815 (o) 10.8999996185 (lo) 10.6000003815 (gs) -252.5 (\(G) 13.8999996185 (SP) 65.4000015259 (A) 71.5999984741 (T) 0 (G) 16.6000003815 (0) 0 (0) 16.5 (0) 0 (3) 16.5 (8) 0 (5) ] TJ
0 -1.220600009 TD
-0.0195000004 Tc
[(050) -5.4000000954 (01,) -362.6000061035 (GSP) 50.7999992371 (A) 63.7000007629 (TG000) -5.4000000954 (2139) -5.4000000954 (0001) -5.4000000954 (,) -356.8999938965 (G) -3.5999999046 (SP) 50.7999992371 (A) 57.9000015259 (T) -1.3999999762 (G0) -5.4000000954 (0011) -5.4000000954 (77100) -5.4000000954 (1,) -362.700012207 (GSP) ] TJ
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0 -1.2264000177 TD
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0 -1.220600009 TD
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0 -1.2264000177 TD
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(Picariello) Tj
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[(-) -6.4000000954 (c) -17.5 (gc) -17.5 (ga) -17.5 (gc) -17.5 (tc) -17.5 (t) ] TJ
-19.2698993683 -1.2264000177 TD
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[(\).) -385.6000061035 (Pl) 17.8999996185 (at) 16.8999996185 (in) 19.3999996185 (um) ] TJ
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-15.3766002655 -1.2264000177 TD
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0 -1.220600009 TD
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<92> Tj
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T*
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0 -1.220600009 TD
[(fo) 12.6999998093 (r) -365.5 (1) -373.5 (mi) 17 (nu) 17 (te) -364.8999938965 (an) 15.5 (d) -371.5 (6) 0 (8) 16.5 0 (C) -361 (f) 0 (o) 12.6999998093 (r) -371.299987793 (3) -367.799987793 (m) 0 (i) 17 (n) 0 (u) 11.1999998093 (t) 0 (e) 16.8999996185 (s) 0 (;) -363.1000061035 (f) 0 (i) 18.7999992371 (v) 0 (e) -373.5 (c) 0 (y) 14.6999998093 (c) 0 (l) 12.8000001907 (e) 0 (s) -365.5 (o) 10.8999996185 (f) -374.299987793 (9) 0 (4) 16.5 0 (C) ] TJ
0 -1.2264000177 TD
[(fo) 12.6999998093 (r) -353.8999938965 (1) -356.200012207 (mi) 17 (nu) 17 (te) 11.1999998093 (,) -354.700012207 (4) 0 (8) 16.5 0 (C) -349.3999938965 (f) 0 (o) 12.6999998093 (r) -353.8999938965 (1) -356.200012207 (m) 0 (i) 17 (n) 0 (u) 17 (t) 0 (e) -353.299987793 (a) 0 (n) 15.5 (d) -354.1000061035 (68) 16.5 -349.3999938965 (fo) 12.6999998093 (r) -353.8999938965 (3) -356.200012207 (mi) 17 (nu) 11.1999998093 (te) 16.8999996185 (s;) ] TJ
T*
[(te) 16.8999996185 (n) -419.8999938965 (c) 0 (y) 14.6999998093 (c) 0 (l) 18.6000003815 (e) 0 (s) -411.799987793 (o) 0 (f) -409.6000061035 (9) 0 (4) 16.5 0 (C) -413.1000061035 (f) 13.3000001907 (or) -412.3999938965 (1) -419.799987793 (m) 11.5 (in) 13.6999998093 (ut) 18.3999996185 (e,) -411 (58) 16.5 -413.1000061035 (f) 13.3000001907 (o) 0 (r) -412.3999938965 (1) -419.799987793 (m) 11.5 (i) 0 (n) 13.6999998093 (u) 0 (t) 18.3999996185 (e) -420.799987793 (an) 15.5 (d) ] TJ
0 -1.220600009 TD
[(68) 16.5 -274.200012207 (fo) 18.3999996185 (r) -284.5 (3) -281 (mi) 11.1999998093 (nu) 17 (te) 16.8999996185 (s;) -276.299987793 (sev) 17.2999992371 (en) 15.5 (te) 11.1999998093 (en) -273.700012207 (cy) 14.6999998093 (cl) 18.6000003815 (es) -278.700012207 (o) 10.8999996185 (f) -281.700012207 (94) 16.5 -274.200012207 (fo) 12.6999998093 (r) -278.700012207 (1) -286.799987793 (m) 11.5 (i) 0 (n) 13.6999998093 (u) 0 (t) 18.3999996185 (e) 0 (,) ] TJ
0 -1.2264000177 TD
[(65) 16.5 -326.299987793 (fo) 18.3999996185 (r) -336.6000061035 (1) -333 (mi) 17 (nu) 17 (te) -330.200012207 (an) 15.5 (d) -331 (6) 0 (8) 16.5 0 (C) -326.299987793 (f) 0 (o) 12.6999998093 (r) -330.799987793 (3) -333 (m) 0 (i) 11.1999998093 (n) 0 (u) 17 (t) 0 (e) 16.8999996185 (s) 0 (;) -328.3999938965 (a) 0 (n) 15.5 (d) -331 (on) 13.3000001907 (e) -345.5 (c) 0 (y) 14.6999998093 (c) 0 (l) 18.6000003815 (e) ] TJ
T*
[(of) -288.200012207 (68) 16.5 -285.799987793 (fo) 18.3999996185 (r) -296.1000061035 (1) 0 (5) -284.299987793 (m) 0 (i) 17 (n) 0 (u) 17 (t) 0 (e) 11.1999998093 (s) -291.799987793 (\(Tech) 16.3999996185 (ne) -233.1999969482 (T) 29.6000003815 (C) 0 (-) 17 (4) 0 (0) 16.5 (0) 0 (0) -290.1000061035 (T) 18.1000003815 (he) 16.1000003815 (rm) 16.2999992371 (al) -282.200012207 (Cy) 13.3000001907 (cl) 12.8000001907 (er) 17.8999996185 (;) ] TJ
0 -1.220600009 TD
[(Kr) 17 (ac) 14.6999998093 (ke) 15.6000003815 (le) 12.8000001907 (r) -614.200012207 (Sci) 13.6999998093 (en) 15.5 (ti) 15.1000003815 (fi) 18.7999992371 (c,) -619.299987793 (Al) 19.2000007629 (ba) 12.5 (ny) 15.5 (,) -615 (N) 0 (Y) 89.0999984741 (,) -615 (US) 12.6000003815 (A\)) 17.6000003815 (.) -615 (T) 18.1000003815 (he) -608.700012207 (pr) 15.1000003815 (od) 15.5 (uc) 16.1000003815 (ts) ] TJ
0 -1.2264000177 TD
[(we) 15.8999996185 (re) -294.5 (cl) 12.8000001907 (ea) 14.6999998093 (ne) 15.5 (d) -290.5 (u) 0 (s) 12 (i) 11.1999998093 (ng) -288 (th) 18.3999996185 (e) -293.5 (P) 0 (r) 17.2000007629 (e) 0 (p) 11.8999996185 (Easy) -287.8999938965 (Ge) 11.6000003815 (l) -289.6000061035 (E) 0 (x) 15.5 (t) 0 (r) 14.3999996185 (a) 0 (c) 14.6999998093 (t) 0 (i) 15.1000003815 (o) 0 (n) -287.5 (K) 12.3000001907 (it) -285.799987793 (\(A) 11.8000001907 (ff) 15.1000003815 (y-) ] TJ
T*
[(me) 13.1000003815 (tr) 20.1000003815 (ix) 14.3000001907 (\).) -408.700012207 (T) 18.1000003815 (h) 0 (e) -412 (r) 0 (e) 12.1000003815 (s) 0 (u) 17.7000007629 (l) 0 (t) 15.1000003815 (i) 11.1999998093 (ng) -415.299987793 (D) 11.6999998093 (N) 0 (A) -412.1000061035 (was) -414.799987793 (tr) 14.3999996185 (ea) 14.6999998093 (te) 16.8999996185 (d) -417.700012207 (w) 0 (i) 14 (t) 0 (h) -409.700012207 (r) 0 (e) 12.1000003815 (s) 0 (t) 18.6000003815 (r) 0 (i) 16 (c) 0 (t) 16.8999996185 (i) 0 (o) 16.3999996185 (n) ] TJ
0 -1.220600009 TD
[(en) 15.5 (zy) 16.2000007629 (me) 13.1000003815 (s) -14.1999998093 (,) -285.299987793 (cl) 12.8000001907 (ea) 14.6999998093 (ne) 15.5 (d) -290.5 (a) 0 (g) 17.7000007629 (a) 0 (i) 12.8000001907 (n) -286.799987793 (us) 12 (i) 11.1999998093 (n) 0 (g) -282.200012207 (t) 0 (h) 12.6000003815 (e) -287.700012207 (Pr) 11.3999996185 (e) 13.1000003815 (pEas) 10.1000003815 (y) -293.5 (G) 0 (e) 17.3999996185 (l) -295.3999938965 (E) 12.3999996185 (x) 0 (t) 12.6999998093 (r) 0 (a) 17.8999996185 (c) 0 (t) 11.1999998093 (i) 11.1999998093 (o) 0 (n) ] TJ
0 -1.2264000177 TD
[(Ki) 17.7000007629 (t) -372.200012207 (a) 0 (n) 15.5 (d) -371.5 (li) 16.7000007629 (ga) 12 (te) 16.8999996185 (d) -371.5 (i) 11.1999998093 (nt) 12 (o) -370.8999938965 (t) 0 (h) 18.3999996185 (e) -374.5 (pP) 17 (XV) 43.4000015259 (-) 11.1000003815 (5) ] TJ
/F10 1 Tf
13.4791002274 0 TD
() Tj
/F7 1 Tf
0.3759999871 0 TD
[(-3) 13.6000003815 (xF) 14 (L) -22.2999992371 (A) 0 (G) -363.700012207 (p) 0 (l) 15.8000001907 (asm) 16.2999992371 (id) -366 (us) 17.7000007629 (in) 13.6999998093 (g) ] TJ
-13.855099678 -1.2264000177 TD
-0.0170000009 Tc
[(the) -275.799987793 (L) 1.2000000477 (igate-I) 3.5999999046 (T) -276.6000061035 (Kit) -279.299987793 (\() 4.1999998093 (Affymetri) 5.8000001907 (x) -2.4000000954 (\)) 4.1999998093 (.) -279.200012207 (T) 12.6000003815 (h) -2.4000000954 (e) -275.799987793 (m) 0.3000000119 (ixture) -275.799987793 (wa) -17 (s) -266.799987793 (t) -1.6000000238 (hen) -274.8999938965 (t) -1.6000000238 (r) 5.0999999046 (a) 1.8999999762 (ns) -17 (-) ] TJ
0 -1.220600009 TD
-0.0183000006 Tc
[(formed) -719.5 (into) -724.700012207 (OneShot) -720.299987793 (c) 0.6000000238 (ompe) -5.1999998093 (tent) -720.200012207 (cells) -720.9000244141 (\(Invitrogen/Life) ] TJ
0 -1.2264000177 TD
0 Tc
[(Tec) 9.6000003815 (hn) 17 (o) 10.8999996185 (l) 0 (o) 10.6000003815 (g) 0 (i) 21.7000007629 (e) 0 (s) 10.5 (\)) 0 (,) -431.8999938965 (a) 0 (n) 15.5 (d) -446.700012207 (th) 18.3999996185 (e) -449.700012207 (r) 0 (e) 17.8999996185 (s) 0 (u) 17.7000007629 (l) 0 (t) 15.1000003815 (i) 0 (n) 13.6999998093 (g) -440.799987793 (co) 12.5 (l) 11.1999998093 (o) 0 (n) 13.3000001907 (i) 11.1999998093 (es) -440.700012207 (we) 15.8999996185 (re) -439.1000061035 (sc) 16.2999992371 (re) 17.8999996185 (en) 15.5 (ed) ] TJ
T*
[(fo) 12.6999998093 (r) -706.799987793 (p) 0 (o) 15.5 (s) 0 (i) 14.3999996185 (t) 0 (i) 20.7999992371 (v) 0 (e) 14.1000003815 (s) 0 (.) -704.4000244141 (P) 0 (o) 17.5 (s) 0 (i) 14.3999996185 (t) 0 (i) 15.1000003815 (v) 12.6000003815 (e) -721.5999755859 (c) 0 (l) 12.8000001907 (o) 10.8999996185 (ne) 15.5 (s) -714.200012207 (w) 0 (e) 15.8999996185 (r) 0 (e) -699.5 (s) 0 (e) 16.2999992371 (q) 0 (u) 13.3000001907 (e) 0 (n) 15.5 (c) 0 (e) 14.6999998093 (d) -707 (at) -706.200012207 (th) 18.3999996185 (e) ] TJ
0 -1.220600009 TD
[(Ve) 17.5 (rm) 16.2999992371 (on) 13.3000001907 (t) -262.299987793 (C) 11.6999998093 (an) 15.5 (ce) 14.6999998093 (r) -261.3999938965 (C) 11.6999998093 (en) 15.5 (te) 16.8999996185 (r) -261.3999938965 (D) 0 (N) 13.8000001907 (A) -258.1000061035 (An) 16.2000007629 (al) 18.6000003815 (ys) 16.2999992371 (is) -251.6999969482 (F) 28.2999992371 (a) 0 (c) 14.6999998093 (i) 0 (l) 16.7000007629 (i) 0 (t) 15.1000003815 (y) -258.799987793 (\(U) 15.5 (ni) 13.6999998093 (v) 12.6000003815 (e) 0 (r) 12.1000003815 (s) 0 (i) 20.2000007629 (t) 0 (y) ] TJ
0 -1.2264000177 TD
[(of) -253.5 (Ve) 11.6999998093 (rm) 16.2999992371 (o) 10.8999996185 (nt,) -255.8999938965 (Bu) 11.6999998093 (rl) 16 (i) 11.1999998093 (n) 0 (g) 12.8000001907 (t) 0 (o) 20.5 (n) 0 (,) -201.8999938965 (V) -24.6000003815 (T) 87.5 (,) -262.200012207 (U) 11.6999998093 (S) 0 (A) 14.6999998093 (\)) 0 (.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 56.6929016113 360.9637145996 Tm
[(Plasmid) -308.1000061035 (injection) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 348.9447937012 Tm
[(Appr) -7.0999999046 (oximately) -354.299987793 (200) ] TJ
/F11 1 Tf
8.3767004013 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
[(g) -342.5 (o) 0 (f) -346 (pPXV) 25.7000007629 (-3xFL) -35.2000007629 (AG-) ] TJ
/F8 1 Tf
8.7065000534 0 TD
(MKS3) Tj
/F7 1 Tf
2.90989995 0 TD
[(wa) -13 (s) -343.8999938965 (lin-) ] TJ
-20.5368995667 -1.2264000177 TD
[(earized) -550.200012207 (with) -546.0999755859 (NotI) -546.799987793 (\(Affym) -12.1000003815 (etrix\)) -544.5 (overn) -8.3000001907 (ight) -544.299987793 (at) -544.200012207 <3337B043> -546.9000244141 (and) ] TJ
0 -1.220600009 TD
[(then) -324.799987793 (clean) -10.6000003815 (sed) -320.5 (using) -328.3999938965 (an) -320 (organ) -10.5 (ic) -317 (ext) -8.8999996185 (raction) -328.200012207 (meth) -9.1000003815 (od) -320.1000061035 (modi) -8.1000003815 (-) ] TJ
0 -1.2264000177 TD
[(fied) -333.799987793 (from) -329.700012207 (that) -329.1000061035 (des) -8.1000003815 (cribed) -329.8999938965 (ea) -8.5 (rlier.) -327 (This) -323.200012207 (procedur) -10.6999998093 (e) -328.200012207 (require) -9.1000003815 (d) ] TJ
T*
[(tw) 18.2000007629 (o) -272.5 (w) 0 (a) 10.1000003815 (s) 0 (h) 17.7000007629 (e) 13.1000003815 (s) -274.5 (i) 11.1999998093 (n) -269.5 (p) 0 (h) 19.1000003815 (e) 0 (n) 21.2999992371 (o) 0 (l) 16.3999996185 (:) 0 (c) 22.8999996185 (h) 0 (l) 20 (o) 10.8999996185 (ro) 15.6999998093 (f) 13.3000001907 (o) 0 (r) 15.6999998093 (m) 11.5 (:i) 21 (so) 19.8999996185 (am) 18.8999996185 (yl) -259.1000061035 (al) 18.6000003815 (co) 18.2000007629 (ho) 19.7000007629 (l) -272.200012207 (\() 0 (2) 23.7000007629 (5) 0 (:) 18 (2) 0 (4) 22.2999992371 (:) 0 (1) 18 (\)) ] TJ
0 -1.220600009 TD
[(fo) 12.6999998093 (l) 11.1999998093 (l) 0 (o) 16.3999996185 (w) 0 (e) 15.8999996185 (d) -562.4000244141 (b) 10.8999996185 (y) -565.4000244141 (tw) 18.2000007629 (o) -561.799987793 (was) 13.3000001907 (he) 16.1000003815 (s) -563.700012207 (o) 10.8999996185 (f) -559.4000244141 (c) 0 (h) 16.1000003815 (l) 0 (o) 16.3999996185 (r) 0 (o) 15.6999998093 (f) 0 (o) 12.6999998093 (r) 0 (m) 16.2999992371 (:) 0 (i) 15.1999998093 (s) 0 (o) 14.1000003815 (a) 0 (m) 18.8999996185 (y) 0 (l) -554.0999755859 (a) 0 (l) 18.6000003815 (c) 0 (o) 12.5 (h) 0 (o) 13.8999996185 (l) ] TJ
0 -1.2264000177 TD
[(\(2) 17.8999996185 (4:) 12.1999998093 (1\)) 17.8999996185 (.) -296.8999938965 (T) 18.1000003815 (he) -290.5 (fi) 13 (na) 15.5 (l) -295.3999938965 (p) 0 (e) 17.7000007629 (l) 0 (l) 16.7000007629 (e) 0 (t) -295.5 (was) -293.299987793 (re) 17.8999996185 (su) 17.7000007629 (sp) 13.5 (en) 15.5 (de) 17.7000007629 (d) -296.299987793 (i) 0 (n) -292.8999938965 (5) 0 (0) ] TJ
/F11 1 Tf
18.963300705 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
0.2946999967 Tc
[(lo) 294.700012207 (fM) 294.700012207 (i) 313.1000061035 (l) 294.700012207 (l) 311.3999938965 (i) 294.700012207 (Q) ] TJ
-19.4955005646 -1.2264000177 TD
0 Tc
[(wa) 15.8999996185 (te) 11.1999998093 (r) -313.3999938965 (\(EMD) -317.799987793 (Mi) 18.3999996185 (ll) 16.7000007629 (ip) 15.8000001907 (or) 15.6999998093 (e,) -306.8999938965 (Bi) 14.1999998093 (ll) 16.7000007629 (er) 12.1000003815 (i) 11.1999998093 (c) 0 (a) -8.5 (,) -314.200012207 (M) -16 (A) -20.8999996185 (,) -320 (U) 11.6999998093 (SA) 14.6999998093 (\),) -310.3999938965 (an) 15.5 (d) -319.3999938965 (t) 0 (h) 18.3999996185 (e) -328.200012207 (co) 12.5 (n-) ] TJ
0 -1.220600009 TD
[(ce) 14.6999998093 (nt) 17.7999992371 (ra) 12.1000003815 (ti) 20.7999992371 (on) -380 (was) -385.8999938965 (ch) 16.1000003815 (eck) 11.3999996185 (ed) -375.700012207 (us) 12 (i) 11.1999998093 (n) 0 (g) -380.6000061035 (a) -397.6000061035 (sp) 13.5 (ect) 12.6999998093 (ro) 15.6999998093 (ph) 19.1000003815 (ot) 14.6999998093 (om) 16.7000007629 (et) 11.1999998093 (er) -375.5 (\(A) 11.8000001907 (gi) 15.8999996185 (-) ] TJ
0 -1.2264000177 TD
[(le) 18.6000003815 (nt) -479.700012207 (Tec) 15.3999996185 (hn) 11.1999998093 (o) 10.8999996185 (l) 0 (o) 16.3999996185 (g) 0 (i) 15.8999996185 (es,) -488.799987793 (Sa) 14 (nt) 17.7999992371 (a) -484.3999938965 (C) 0 (l) 17.2000007629 (a) 0 (r) 12.1000003815 (a) -10 (,) -482 (C) -17.2000007629 (A) -20.8999996185 (,) -482 (US) 12.6000003815 (A\)) 17.6000003815 (.) -482 (T) 18.1000003815 (he) -475.6000061035 (sa) 10.5 (m) 11.5 (p) 0 (l) 15.8000001907 (e) ] TJ
T*
[(was) -270.200012207 (sp) 19.2999992371 (un) -266.5 (at) -260.700012207 (16) 16.5 (,0) 18 (00) -185.8999938965 ] TJ
/F8 1 Tf
8.7237997055 0 TD
(g) Tj
/F7 1 Tf
0.6883999705 0 TD
[(\(E) 16.2000007629 (pp) 14.8999996185 (en) 15.5 (do) 15.5 (rf) -265.3999938965 (C) 11.6999998093 (e) 0 (n) 15.5 (t) 0 (r) 14.3999996185 (i) 0 (f) 13 (u) 0 (g) 19.2000007629 (e) -270.299987793 (54) 16.5 (24) 16.5 (\)) -273.8999938965 (f) 0 (o) 12.6999998093 (r) -267.1000061035 (10) ] TJ
-9.4121999741 -1.220600009 TD
[(mi) 17 (nu) 17 (te) 11.1999998093 (s) -390.200012207 (t) 0 (o) -378.6000061035 (p) 0 (e) 11.8999996185 (l) 11.1999998093 (le) 12.8000001907 (t) -389.6000061035 (d) 0 (e) 17.7000007629 (b) 0 (r) 15.6999998093 (i) 0 (s) 14.3999996185 (.) -389.3999938965 (T) 18.1000003815 (h) 0 (e) -383.1000061035 (t) 0 (o) 14.6999998093 (p) -388.799987793 (45) ] TJ
/F11 1 Tf
15.7525997162 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
[(l) -387.8999938965 (was) -385.8999938965 (ca) 14.6999998093 (re) 12.1000003815 (f) 13.3000001907 (u) 0 (l) 14.1999998093 (l) 0 (y) -380.6000061035 (r) 0 (e) 12.1000003815 (-) ] TJ
-16.2849006653 -1.2264000177 TD
[(mo) 16.6000003815 (ve) 14.1000003815 (d) -492.8999938965 (a) 0 (n) 15.5 (d) -493 (pl) 15.8000001907 (ac) 14.6999998093 (ed) -485.6000061035 (in) -489.6000061035 (a) -490.200012207 (f) 0 (r) 12.3000001907 (e) 0 (s) 16.2999992371 (h) -494.5 (RN) 14.5 (ase) 12.1000003815 (/) 11.1000003815 (D) 0 (N) 13.8000001907 (ase) 12.1000003815 (-) 11.1000003815 (f) 0 (r) 12.3000001907 (e) 0 (e) -482.799987793 (1) 0 (.) 12.1999998093 (5) 0 (-) 19.3999996185 (m) 0 (l) ] TJ
T*
[(Ep) 17 (pe) 11.8999996185 (nd) 18.5 (or) 15.6999998093 (f) -345.3999938965 (t) 0 (u) 12.6000003815 (b) 10.8999996185 (e) -351.299987793 (a) 0 (n) 15.5 (d) -348.299987793 (ag) 17.7000007629 (ai) 18.6000003815 (n) -350.5 (d) 0 (r) 15.1000003815 (i) 11.1999998093 (ed) -341 (i) 11.1999998093 (n) -350.5 (a) -357.1000061035 (s) 0 (p) 13.5 (e) 13.1000003815 (ed) -341 (va) 14.1000003815 (c.) -341.6000061035 (T) 18.1000003815 (h) 0 (e) -336.799987793 (f) 0 (i) 13 (n) 0 (a) 15.5 (l) ] TJ
0 -1.220600009 TD
[(pe) 17.7000007629 (ll) 16.7000007629 (et) -388 (was) -385.8999938965 (re) 17.8999996185 (su) 12 (sp) 19.2999992371 (en) 15.5 (de) 11.8999996185 (d) -388.799987793 (i) 11.1999998093 (n) -396.700012207 (M) 13 (il) 10.8999996185 (l) 11.1999998093 (i) 0 (Q) -382.1000061035 (w) 0 (a) 15.8999996185 (t) 0 (e) 11.1999998093 (r) -388.6000061035 (to) -384.3999938965 (ob) 16 (ta) 11.1999998093 (i) 11.1999998093 (n) -391 (a) -391.799987793 (c) 0 (o) 12.5 (n) 0 (-) ] TJ
0 -1.2264000177 TD
[(ce) 14.6999998093 (nt) 17.7999992371 (ra) 12.1000003815 (ti) 20.7999992371 (on) -339.6000061035 (be) 12.5 (tw) 12.3999996185 (ee) 14.6999998093 (n) -344.700012207 (3) -344.6000061035 (an) 15.5 (d) -348.299987793 (9) ] TJ
/F11 1 Tf
11.8129997253 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
(g/) Tj
/F11 1 Tf
0.8273000121 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
[(l) -347.3999938965 (a) 0 (n) 15.5 (d) -348.299987793 (st) 18.6000003815 (or) 15.6999998093 (ed) -341 (at) -335.8999938965 <34B0> 11.6000003815 (C) -347 (u) 0 (n) 17 (t) 0 (i) 15.1000003815 (l) ] TJ
-13.70470047 -1.2264000177 TD
[(in) 13.6999998093 (j) 12.8000001907 (ect) 12.6999998093 (io) 16.3999996185 (n.) ] TJ
0.8156999946 -1.220600009 TD
[(Appr) -7.0999999046 (oximat) -10 (ely) -379 (20) -376.799987793 (cells) -382 (whic) -10.3999996185 (h) -373 (had) -384.299987793 (re) -11 (cently) -388.6000061035 (undergone) ] TJ
-0.8156999946 -1.2264000177 TD
[(autogamy) -557.4000244141 (wer) -8.3000001907 (e) -548 (placed) -553.5 (under) -550.700012207 (high-t) -9.5 (empera) -9.1999998093 (ture) -548 (sili) -9.3999996185 (con) ] TJ
T*
[(oil) -331.1000061035 (to) -332.3999938965 (immobiliz) -11.1999998093 (e) -334 (them.) -334.799987793 (Appro) -7.6999998093 (ximately) -336.299987793 (5) -333 (t) 0 (o) -326.6000061035 (5) 0 (0) -330.6000061035 (p) 0 (g) -332.1000061035 (o) 0 (f) -334.3999938965 (the) ] TJ
0 -1.220600009 TD
[(pla) -11.6000003815 (smi) -8.8000001907 (d) -359.8999938965 (w) 0 (a) -13 (s) -355.5 (inje) -18.2999992371 (cted) -364.6000061035 (into) -365 (the) -361.8999938965 (macronu) -10.6000003815 (cleus) -367.1000061035 (of) -357.6000061035 (each) -368.3999938965 (cell) ] TJ
0 -1.2264000177 TD
[(using) -363.1000061035 (a) -357.1000061035 (pulled) -363 (capillar) -10.1999998093 (y) -357.1000061035 (and) -361.700012207 (a) -357.1000061035 (Narishi) -9.1999998093 (ge) -358.299987793 (microma) -10.6000003815 (nipula-) ] TJ
T*
[(tor) -616.9000244141 (\(Narish) -10.8000001907 (ige) -613.200012207 (Interna) -9.1999998093 (tional) -618.299987793 (USA) -37.2999992371 (,) -609.299987793 (E) -16.5 (a) -10 (s) 0 (t) -612 (Mead) -8.3000001907 (ow,) -618.700012207 (N) -9.3999996185 (Y) 81.1999969482 (,) ] TJ
0 -1.220600009 TD
[(USA\).) -307.200012207 (Ind) -7.0999999046 (ividual) -309.1000061035 (inje) -12.5 (cted) -312.5 (cells) -306.799987793 (were) -307.5 (transfe) -9.8999996185 (rred) -308.299987793 (to) -303.3999938965 (750) ] TJ
/F11 1 Tf
23.0590991974 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
(l) Tj
-23.6028995514 -1.2264000177 TD
[(of) -687.299987793 (inoc) -8.6000003815 (ulated) -697.4000244141 (culture) -694.200012207 (fluid) -691.4000244141 (in) -692.0999755859 (depression) -698.4000244141 (slides) -694 (and) ] TJ
25.3094997406 64.8964004517 TD
[(incuba) -9.8000001907 (ted) -464.3999938965 (in) -466.5 (a) -467 (humidifyin) -13.6999998093 (g) -464 (chambe) -10.3999996185 (r) -463.799987793 (a) 0 (t) -463.200012207 (R) 18.1000003815 (T) -404.200012207 (for) -468.5 (2) -466.1000061035 (days) -23.8999996185 (,) ] TJ
0 -1.220600009 TD
[(allowing) -366.299987793 (the) -367.700012207 (cells) -358.799987793 (to) -361.299987793 (re) -11.1000003815 (cover) -362.1000061035 (and) -355.8999938965 (di) -7.3000001907 (vide.) -359.5 (Cells) -360.200012207 (were) -359.6000061035 (then) ] TJ
0 -1.2264000177 TD
[(transfe) -9.8999996185 (rred) -539.700012207 (to) -540.5999755859 (test) -543 (tubes) -538.700012207 (with) -546.0999755859 (inocula) -10.1999998093 (ted) -539.5999755859 (culture) -543.799987793 (fluid) ] TJ
T*
[(and) -477.3999938965 (main) -8 (tained) -484 (at) -474.799987793 (15) -6.5999999046 -476.700012207 (a) -10 (s) -477 (individual) -487.6000061035 (clones.) -485.8999938965 (Genomic) ] TJ
0 -1.220600009 TD
[(DNA) -325.299987793 (wa) -13 (s) -320.799987793 (extracte) -13.1000003815 (d) -319.3999938965 (from) -324 (the) -333 (clon) -8.6000003815 (e) -328.200012207 (cult) -9.3000001907 (ures) -323.1000061035 (a) -10 (s) -320.799987793 (des) -8.1000003815 (cribed) ] TJ
0 -1.2264000177 TD
[(pre) -12.3000001907 (viou) -8.6000003815 (sly) -464.200012207 (\(see) -464.299987793 (Sequen) -9.1999998093 (ce) -465.5 (analysis) -467.3999938965 (an) -7.5999999046 (d) -458.200012207 (con) -8.3000001907 (struct) -465.799987793 (design) ] TJ
T*
[(text) -473.700012207 (se) -12.6000003815 (ction) -10.6000003815 (\)) -459 (and) -465.799987793 (tested) -467.5 (by) -461.8999938965 (P) -10.6999998093 (C) 0 (R) -461.8999938965 (using) -461.5 (pla) -17.3999996185 (smid-sp) -8.5 (e) -10 (cific) ] TJ
0 -1.220600009 TD
[(primer) -7.9000000954 (s) -8.3999996185 (:) -406.799987793 (the) -402.3999938965 (forw) -8.6999998093 (ard) -405.700012207 (primer) -407.1000061035 (for) -404.8999938965 (the) -408.200012207 (pla) -11.6000003815 (smid) -409.200012207 (pPXV) -408.200012207 (\(5) ] TJ
/F10 1 Tf
23.1112003326 0 TD
() Tj
/F7 1 Tf
0.3876000047 0 TD
(-) Tj
-23.4988002777 -1.2264000177 TD
[(taaga) -10.1000003815 (tgaatggaa) -12.8000001907 (tataatg-3) ] TJ
/F10 1 Tf
9.6956996918 0 TD
() Tj
/F7 1 Tf
0.3817999959 0 TD
[(\)) -372.200012207 (and) -373.299987793 (a) -368.700012207 (r) 0 (e) -16.7999992371 (verse) -375.6000061035 (primer) -372.3999938965 (\(5) ] TJ
/F10 1 Tf
10.7601995468 0 TD
() Tj
/F7 1 Tf
0.3876000047 0 TD
(-gaaaa) Tj
-21.2252998352 -1.2264000177 TD
[(cccaag) -10.8000001907 (ccaatcaa) -14.3000001907 (tac-3) ] TJ
/F10 1 Tf
8.2667999268 0 TD
() Tj
/F7 1 Tf
0.3817999959 0 TD
[(\),) -634.4000244141 (wh) 17.2999992371 (ic) 12.8000001907 (h) -592.9000244141 (was) -582.5999755859 (se) 16.2999992371 (qu) 13.3000001907 (en) 15.5 (ce) 14.6999998093 (-s) 14.3000001907 (pec) 13.3999996185 (i) 11.1999998093 (f) 0 (i) 13 (c) -588.5 (fo) 12.6999998093 (r) ] TJ
/F8 1 Tf
-8.6485996246 -1.220600009 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.5281000137 0 TD
0.4762000144 Tc
[(.D) 476.200012207 (N) 490 (A) 4.0999999046 (\() 476.200012207 (1) ] TJ
/F11 1 Tf
4.6395998001 0 TD
0 Tc
() Tj
/F7 1 Tf
0.5321999788 0 TD
[(l,) -465 (ap) 11.8999996185 (pr) 20.8999996185 (ox) 14 (im) 17 (at) 11.1999998093 (el) 18.6000003815 (y) -478.6000061035 (4) 0 (0) 16.5 (0) -471.8999938965 (ng) 18.6000003815 (\)) -476.299987793 (was) -472.6000061035 (us) 17.7000007629 (ed) -468.299987793 (i) 11.1999998093 (n) ] TJ
-7.6999001503 -1.2264000177 TD
[(ea) 14.6999998093 (ch) -296.299987793 (PCR) 13.3000001907 (:) -302.700012207 (o) 0 (n) 13.3000001907 (e) -310.799987793 (cy) 14.6999998093 (cl) 18.6000003815 (e) -305.1000061035 (a) 0 (t) -295.5 (9) 0 (5) 16.5 0 (C) -297.3999938965 (f) 0 (o) 18.5 (r) -301.8999938965 (5) -304.1000061035 (m) 0 (i) 17 (n) 0 (u) 17 (t) 0 (e) 11.1999998093 (s) -303.3999938965 (f) 13.3000001907 (o) 0 (l) 10.6000003815 (l) 11.1999998093 (ow) 13.6999998093 (ed) -294.700012207 (by) -294.1000061035 (30) ] TJ
T*
[(cy) 14.6999998093 (cl) 18.6000003815 (es) -359.700012207 (at) -359.1000061035 (95) 16.5 -355.200012207 (fo) 18.3999996185 (r) -365.5 (1) -362 (mi) 11.1999998093 (nu) 17 (te) 16.8999996185 (,) -366.299987793 (4) 0 (0) 16.5 0 (C) -355.200012207 (f) 0 (o) 18.3999996185 (r) -365.5 (1) -367.799987793 (m) 11.5 (in) 13.6999998093 (ut) 18.3999996185 (e) -368.700012207 (a) 0 (n) 15.5 (d) -359.8999938965 (72) 16.5 ] TJ
0 -1.220600009 TD
[(fo) 12.6999998093 (r) -261.3999938965 (3) -257.799987793 (mi) 17 (nu) 11.1999998093 (te) 16.8999996185 (s) -262.8999938965 (f) 0 (o) 18.3999996185 (l) 0 (l) 16.7000007629 (o) 0 (w) 13.6999998093 (e) 0 (d) -254.1999969482 (b) 0 (y) -253.6000061035 (o) 0 (n) 13.3000001907 (e) -264.6000061035 (15) 16.5 (-) 11.1000003815 (m) 0 (i) 17 (n) 0 (u) 11.1999998093 (t) 0 (e) -260.700012207 (c) 0 (y) 14.6999998093 (c) 0 (l) 12.8000001907 (e) -258.799987793 (at) -255 (72) 16.5 15 (.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 516.9259033203 Tm
[(Localizati) -10.6000003815 (on,) -298.5 (visua) -8.8999996185 (lization) -305.299987793 (and) -300.8999938965 (analys) -8 (is) -301.5 (of) -303 (FLAG-MKS3p) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 504.9637145996 Tm
[(We) -295.8999938965 (tested) -299.700012207 (small) -296.799987793 (culture) -11.6000003815 (s) -291.8999938965 (o) 0 (f) -293.8999938965 (individual) -302.5 (clones) -298.8999938965 (to) -291.8999938965 (a) -10 (scerta) -12.5 (in) ] TJ
0 -1.2264000177 TD
[(whether) -320.8999938965 (the) -327.200012207 (cells) -318.299987793 (expressed) -319.200012207 (the) -315.6000061035 (prote) -9.1000003815 (in) -310.299987793 (and) -315.3999938965 (where) -316.1000061035 (it) -314.700012207 (wa) -13 (s) ] TJ
T*
[(local) -9.8000001907 (ized.) -351.6000061035 (A) -350.700012207 (10-ml) -348.799987793 (cult) -9.3000001907 (ure) -349.3999938965 (of) -351.799987793 (inje) -12.5 (cted) -353 (ce) -8.5 (lls) -350.3999938965 (wa) -13 (s) -349.700012207 (added) -353.5 (to) ] TJ
0 -1.220600009 TD
[(50) -371.1000061035 (ml) -370.6000061035 (of) -374.8999938965 (inocula) -10.1999998093 (ted) -371.8999938965 (culture) -376.1000061035 (fluid) -379 (and) -373.299987793 (grown) -373.700012207 (at) -370.700012207 <3232B043> -373.3999938965 (for) ] TJ
0 -1.2264000177 TD
[(appro) -8.3999996185 (ximately) -405.700012207 (48) -394.200012207 (to) -396 (72) -394.200012207 (hours) -9.8999996185 (.) -395.200012207 (T) 12.3000001907 (he) -406.200012207 (cel) -8.8000001907 (ls) -390.5 (wer) -8.3000001907 (e) -391.799987793 (immu) -9 (no-) ] TJ
T*
[(stained) -336.1000061035 (and) -332.799987793 (image) -10 (d) -325.200012207 (a) -15.8000001907 (s) -326.6000061035 (des) -8.1000003815 (cribed) -335.700012207 (below.) -334.700012207 (Imag) -8 (es) -330.799987793 (were) -336.5 (an-) ] TJ
0 -1.220600009 TD
[(alyze) -9.8999996185 (d) -498.700012207 (for) -509 (colocaliz) -23.5 (ation) -508.1000061035 (using) -507.799987793 (softWoR) -23.1000003815 (x) -500.200012207 (Pro) -509.8999938965 (software) ] TJ
0 -1.2264000177 TD
[(\(App) -8 (lied) -538.299987793 (Pre) -16 (cision,) -539.799987793 (Iss) -7.6999998093 (aquah,) -543.5999755859 (WA) -34.9000015259 (,) -534.0999755859 (USA) -8.3999996185 (\).) -536 (Exper) -8.3999996185 (iment) -15.6999998093 (s) ] TJ
T*
[(were) -307.5 (repeated) -311.700012207 (five) -302.700012207 (times) -9.1999998093 (.) ] TJ
0.8156999946 -1.220600009 TD
[(To) -254.5 (i) 11.1999998093 (s) 0 (o) 14.1000003815 (l) 11.1999998093 (at) 11.1999998093 (e) -253 (p) 0 (e) 11.8999996185 (l) 11.1999998093 (li) 16.7000007629 (cl) 12.8000001907 (e) -258.799987793 (m) 11.5 (em) 13.1000003815 (br) 15.6999998093 (an) 15.5 (e) -258.799987793 (a) 0 (n) 15.5 (d) -255.8000030518 (wh) 11.6000003815 (o) 10.8999996185 (l) 0 (e) -264.8999938965 (c) 0 (i) 18.6000003815 (l) 0 (i) 16.7000007629 (a) -258.799987793 (me) 13.1000003815 (m) 11.5 (b) 0 (r) 15.6999998093 (a) 0 (n) 15.5 (e) 0 (,) ] TJ
-0.8156999946 -1.2264000177 TD
-0.0126999998 Tc
[(w) -12.6999998093 (i) 1.2999999523 (ld) -12.6999998093 (-t) -12.6999998093 (yp) -12.6999998093 (e) -324.799987793 (\() -12.6999998093 (st) -12.6999998093 (o) 7.8000001907 (c) -12.6999998093 (k) -332.6000061035 (5) -12.6999998093 (1) 3.7999999523 (s) ] TJ
/F8 1 Tf
8.5908002853 0 TD
0 Tc
[(P.) -313.3999938965 (te) 14.8999996185 (tr) 25.8999996185 (au) 18.5 (re) 15.8000001907 (li) 18.2000007629 (a) ] TJ
/F7 1 Tf
5.3973999023 0 TD
[(\)) -320.1000061035 (c) 0 (e) 14.6999998093 (l) 0 (l) 16.7000007629 (s) -326.6000061035 (ex) 16.2000007629 (pr) 15.1000003815 (e) 13.1000003815 (s) 0 (s) 12.1999998093 (i) 11.1999998093 (ng) -316.8999938965 (F) 10.8999996185 (L) -28.1000003815 (AG) ] TJ
-13.9882001877 -1.2264000177 TD
[(\() 15.3999996185 (c) 13.1000003815 (on) 13.3000001907 (tr) 14.3999996185 (o) 10.8999996185 (l) 0 (\)) -308.8999938965 (o) 0 (r) -308.299987793 (F) 10.8999996185 (L) -22.2999992371 (A) 0 (G) 12.3000001907 (-) 0 (M) 12.5 (K) 12.3000001907 (S3) -309 (\(Te) 11.8999996185 (st) 18.6000003815 (\)) -314.3999938965 (w) 0 (e) 10.1000003815 (r) 0 (e) -306.1000061035 (m) 11.5 (ai) 12.8000001907 (nt) 17.7999992371 (ai) 12.8000001907 (ne) 15.5 (d) -313.6000061035 (i) 11.1999998093 (n) -315.799987793 (l) 0 (a) 12.8000001907 (r) 0 (g) 20.8999996185 (e) ] TJ
0 -1.220600009 TD
[(cu) 16.1000003815 (lt) 15.1000003815 (ur) 13.5 (es) -330.799987793 (\(3) -335 (to) -332.3999938965 (6) -338.799987793 (L) -340.5 (of) -334.3999938965 (cu) 16.1000003815 (lt) 15.1000003815 (ur) 13.5 (e) -339.799987793 (f) 0 (l) 18.7999992371 (u) 0 (i) 14.1999998093 (d) 0 (\)) -332.8999938965 (a) 0 (t) -335.8999938965 (2) 0 (2) 16.5 0 (C) -332.1000061035 (u) 0 (n) 17 (t) 0 (i) 15.1000003815 (l) -341.6000061035 (a) -339.799987793 (d) 0 (e) 17.7000007629 (n) 0 (s) 17.2000007629 (i) 0 (t) 15.1000003815 (y) ] TJ
0 -1.2264000177 TD
[(of) -461.700012207 (8,) 18 (00) 16.5 (0) -466.1000061035 (t) 0 (o) -459.6000061035 (1) 0 (2) 16.5 (,) 0 (0) 18 (0) 0 (0) -457.799987793 (c) 0 (e) 14.6999998093 (l) 0 (l) 16.7000007629 (s) 0 (/) 14.3000001907 (m) 0 (l) -457.3999938965 (was) -466.8999938965 (ac) 14.6999998093 (hi) 20 (eve) 9.8999996185 (d.) -460.1000061035 (F) 10.8999996185 (o) 0 (r) -458.700012207 (p) 0 (e) 11.8999996185 (l) 11.1999998093 (li) 16.7000007629 (cu) 16.1000003815 (la) 12.8000001907 (r) ] TJ
T*
[(me) 13.1000003815 (m) 11.5 (b) 0 (r) 15.6999998093 (a) 0 (n) 15.5 (e) 0 (,) -451.5 (c) 0 (e) 14.6999998093 (l) 11.1999998093 (ls) -448.3999938965 (we) 10.1000003815 (re) -444.8999938965 (ha) 16.1000003815 (r) -24.2000007629 (v) 0 (e) 14.1000003815 (s) 0 (t) 18.6000003815 (e) 0 (d) -450.8999938965 (a) 0 (s) -458.1000061035 (d) 0 (e) 11.8999996185 (s) 0 (c) 16.2999992371 (r) 0 (i) 16 (b) 10.8999996185 (ed) -450.8999938965 (pr) 15.1000003815 (evi) 13.8000001907 (o) 10.8999996185 (u) 0 (s) 12 (l) 11.1999998093 (y) ] TJ
0 -1.220600009 TD
[([) 9.6000003815 (2) 0 (9) 16.5 (]) 0 (.) -437.700012207 (I) 0 (n) -434 (s) 0 (e) 16.2999992371 (p) 0 (a) 11.8999996185 (r) 0 (a) 17.8999996185 (t) 0 (e) -434.299987793 (e) 0 (x) 10.3999996185 (p) 0 (e) 17.7000007629 (r) 0 (i) 16 (m) 0 (e) 13.1000003815 (nts,) -449.3999938965 (ci) 18.6000003815 (li) 16.7000007629 (a) -443.8999938965 (w) 0 (e) 10.1000003815 (r) 0 (e) -433.3999938965 (s) 0 (e) 16.2999992371 (p) 0 (a) 17.7000007629 (r) 0 (a) 12.1000003815 (t) 0 (e) 16.8999996185 (d) -446.700012207 (f) 13.3000001907 (r) 0 (o) 15.6999998093 (m) ] TJ
0 -1.2264000177 TD
[(ce) 14.6999998093 (l) 11.1999998093 (l) -393.700012207 (bo) 16 (di) 15.8000001907 (es) -388.6000061035 (an) 15.5 (d) -388.799987793 (c) 0 (o) 12.5 (l) 11.1999998093 (lect) 18.2000007629 (ed) -387.299987793 (as) -394.3999938965 (pr) 20.8999996185 (evio) 18.8999996185 (us) 17.7000007629 (ly) -386.3999938965 (de) 11.8999996185 (sc) 16.2999992371 (ri) 16 (b) 10.8999996185 (e) 0 (d) -387.299987793 ([) 9.6000003815 (30) 16.5 (]) -395.3999938965 (u) 0 (p) ] TJ
T*
[(to) -396 (th) 18.3999996185 (e) -403.3999938965 (p) 0 (o) 15.5 (i) 11.1999998093 (nt) -392.8999938965 (of) -392.299987793 (se) 16.2999992371 (pa) 11.8999996185 (ra) 17.8999996185 (ti) 15.1000003815 (on) -391.6000061035 (of) -392.299987793 (th) 12.6000003815 (e) -409.200012207 (c) 0 (i) 12.8000001907 (l) 11.1999998093 (ia) 12.8000001907 (ry) -392.8999938965 (m) 11.5 (e) 0 (m) 13.1000003815 (b) 0 (r) 15.6999998093 (a) 0 (n) 15.5 (e) -403.3999938965 (fr) 18.1000003815 (om) ] TJ
0 -1.220600009 TD
[(th) 12.6000003815 (e) -600.0999755859 (axo) 15.5 (ne) 15.5 (me) 13.1000003815 (.) -597.700012207 (P) 0 (r) 11.3999996185 (o) 10.8999996185 (te) 16.8999996185 (in) -593.799987793 (co) 12.5 (nc) 15.5 (en) 15.5 (tr) 20.1000003815 (at) 11.1999998093 (i) 11.1999998093 (o) 0 (n) 13.3000001907 (s) -598.5 (we) 15.8999996185 (re) -595.299987793 (de) 17.7000007629 (te) 16.8999996185 (rm) 16.2999992371 (in) 13.6999998093 (ed) ] TJ
0 -1.2264000177 TD
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T*
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-14.3758001328 -1.2264000177 TD
[(be) 12.5 (ga) 17.7000007629 (n) -275.299987793 (w) 0 (i) 14 (t) 0 (h) -265.1000061035 (a) 0 (n) -267.8999938965 (i) 0 (n) 13.6999998093 (i) 11.1999998093 (ti) 15.1000003815 (al) -270.700012207 (st) 18.6000003815 (ep) -271.6000061035 (at) -266.5 (95) 16.5 -268.3999938965 (fo) 18.3999996185 (r) -278.700012207 (5) -275.200012207 (mi) 17 (nu) 17 (te) 11.1999998093 (s) -274.5 (a) 0 (n) 15.5 (d) -273.1000061035 (en) 15.5 (de) 11.8999996185 (d) ] TJ
T*
[(wi) 14 (th) -259.299987793 (a) -270.299987793 (f) 13.3000001907 (in) 13.6999998093 (al) -259.1000061035 (st) 12.8000001907 (ag) 17.7000007629 (e) -270.299987793 (a) 0 (t) -255 (7) 0 (2) 16.5 0 (C) -262.6000061035 (f) 0 (o) 18.3999996185 (r) -267.1000061035 (20) -261.1000061035 (mi) 17 (nu) 17 (te) 11.1999998093 (s.) -259 (T) 18.1000003815 (h) 0 (e) ] TJ
/F8 1 Tf
18.7376995087 0 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.8057000637 0 TD
[(RN) 14.5 (Ai) ] TJ
-21.5433998108 -1.220600009 TD
[(co) 12.5 (ns) 17.2000007629 (tr) 20.1000003815 (uc) 10.3000001907 (t) -285.3999938965 (was) -281.700012207 (am) 18.8999996185 (pl) 15.8000001907 (if) 13 (i) 11.1999998093 (e) 0 (d) -277.3999938965 (b) 0 (y) -282.6000061035 (3) 0 (0) -272.700012207 (c) 0 (y) 14.6999998093 (c) 0 (l) 12.8000001907 (e) 0 (s) -278.700012207 (a) 13.1000003815 (t) -291.200012207 (9) 0 (5) 16.5 0 (C) -274.200012207 (f) 0 (o) 12.6999998093 (r) -284.5 (1) -281 (m) 0 (i) 11.1999998093 (n) 0 (u) 17 (t) 0 (e) 16.8999996185 (,) ] TJ
0 -1.2264000177 TD
[(52) 16.5 -245.3000030518 (fo) 18.3999996185 (r) -249.8000030518 (1) -252.1000061035 (mi) 17 (nu) 11.1999998093 (te) -243.3999938965 (an) 15.5 (d) -250 (7) 0 (2) 16.5 0 (C) -245.3000030518 (f) 0 (o) 18.3999996185 (r) -255.6000061035 (2) -246.3000030518 (m) 0 (i) 11.1999998093 (n) 0 (u) 17 (t) 0 (e) 16.8999996185 (s) 0 (.) -247.3999938965 (T) 18.1000003815 (he) ] TJ
/F8 1 Tf
19.2873001099 0 TD
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
2.7132000923 0 TD
[(co) 12.5 (n-) ] TJ
-22.0004997253 -1.2264000177 TD
[(st) 18.6000003815 (ru) 13.5 (ct) -382.200012207 (was) -385.8999938965 (am) 13.1000003815 (pl) 15.8000001907 (i) 11.1999998093 (f) 0 (i) 13 (e) 0 (d) -381.5 (b) 10.8999996185 (y) -391.799987793 (f) 0 (i) 13 (v) 12.6000003815 (e) -403.3999938965 (c) 0 (y) 14.6999998093 (c) 0 (l) 18.6000003815 (e) 0 (s) -382.8999938965 (a) 0 (t) -382.200012207 (9) 0 (5) 16.5 0 (C) -384.1000061035 (f) 0 (o) 18.3999996185 (r) -388.6000061035 (1) -390.8999938965 (m) 0 (i) 17 (n) 0 (u) 11.1999998093 (t) 0 (e) 16.8999996185 (,) ] TJ
0 -1.220600009 TD
[(47) 16.5 -303.1000061035 (fo) 18.3999996185 (r) -307.6000061035 (1) -309.8999938965 (mi) 11.1999998093 (nu) 17 (te) -301.200012207 (an) 15.5 (d) -307.799987793 (7) 0 (2) 16.5 0 (C) -303.1000061035 (f) 0 (o) 18.3999996185 (r) -313.3999938965 (2.) 18 (25) -301.6000061035 (mi) 17 (nu) 17 (te) 11.1999998093 (s;) -299.5 (fo) 12.6999998093 (l) 11.1999998093 (l) 0 (o) 16.3999996185 (w) 0 (e) 15.8999996185 (d) -313.6000061035 (b) 10.8999996185 (y) ] TJ
0 -1.2264000177 TD
[(tw) 12.3999996185 (en) 15.5 (ty) 16.8999996185 (-) 11.1000003815 (f) 0 (i) 13 (v) 0 (e) -292.5 (c) 0 (y) 14.6999998093 (c) 0 (l) 12.8000001907 (e) 0 (s) -284.5 (a) 13.1000003815 (t) -297 (9) 0 (5) 16.5 0 (C) -280 (f) 0 (o) 12.6999998093 (r) -290.299987793 (1) -292.5 (m) 11.5 (in) 13.6999998093 (ut) 18.3999996185 (e,) -283.799987793 (50) 16.5 -285.799987793 (fo) 18.5 (r) -296.1000061035 (1) -286.799987793 (mi) 11.1999998093 (nu) 17 (te) ] TJ
T*
[(an) 15.5 (d) -284.700012207 (7) 0 (2) 16.5 0 (C) -274.200012207 (f) 0 (o) 18.3999996185 (r) -284.5 (2.) 18 (25) -278.5 (m) 11.5 (i) 0 (n) 13.6999998093 (u) 0 (t) 18.3999996185 (e) 0 (s) -278.700012207 (\(Tech) 16.3999996185 (ne) -221.6000061035 (T) 18.1000003815 (h) 0 (e) 16.1000003815 (r) 0 (m) 16.2999992371 (a) 0 (l) -276.5 (C) 0 (y) 13.3000001907 (c) 0 (l) 18.6000003815 (e) 0 (r) 12.1000003815 (;) -279.5 (Bi) 14.1999998093 (bb) 16 (y) ] TJ
0 -1.220600009 TD
[(Sci) 13.6999998093 (en) 15.5 (ti) 15.1000003815 (fi) 18.7999992371 (c,) -393.700012207 (Bu) 17.5 (rl) 16 (i) 11.1999998093 (n) 0 (g) 12.8000001907 (t) 0 (o) 14.6999998093 (n) 0 (,) -375.3999938965 (NJ,) -381.8999938965 (US) 12.6000003815 (A\)) 17.6000003815 (.) -389.3999938965 (T) 18.1000003815 (he) -377.299987793 (fi) 13 (na) 15.5 (l) -387.8999938965 (PCR) -380 (pr) 15.1000003815 (o) 10.8999996185 (d) 0 (u) 13.3000001907 (cts) ] TJ
0 -1.2264000177 TD
[(we) 15.8999996185 (re) -375.5 (an) 15.5 (al) 18.6000003815 (yz) 10.5 (ed) -369.8999938965 (on) -380 (0.) 18 (75) 16.5 (%) -384.799987793 (o) 10.8999996185 (r) -382.799987793 (1) 0 (.) 18 (0) 0 (%) -376.5 (a) 0 (g) 17.7000007629 (a) 0 (r) 12.1000003815 (o) 10.8999996185 (se) -377.1000061035 (ge) 17.7000007629 (l) -382.1000061035 (\() 0 (I) 12.8999996185 (n) 0 (v) 15 (i) 11.1999998093 (tr) 14.3999996185 (o) 10.8999996185 (g) 0 (e) 12 (n) 0 (/) ] TJ
T*
[(Li) 17.8999996185 (fe) -280.200012207 (Tec) 15.3999996185 (hn) 11.1999998093 (o) 10.8999996185 (l) 0 (o) 16.3999996185 (g) 0 (i) 15.8999996185 (e) 0 (s) 16.2999992371 (\)) -337.5 (an) 15.5 (d) -336.799987793 (v) 0 (i) 18 (s) 0 (u) 12 (a) 0 (l) 18.6000003815 (i) 0 (z) 14.3999996185 (e) 0 (d) -329.3999938965 (w) 0 (i) 14 (t) 0 (h) -328.700012207 (e) 0 (t) 16.8999996185 (h) 0 (i) 14.1999998093 (d) 0 (i) 15.8000001907 (u) 0 (m) -326.799987793 (b) 0 (r) 15.6999998093 (o) 0 (m) 16.7000007629 (i) 0 (d) 15.8000001907 (e) 0 (.) ] TJ
0 -1.220600009 TD
[(Re) 13.8999996185 (su) 17.7000007629 (lt) 15.1000003815 (i) 11.1999998093 (n) 0 (g) -264.8999938965 (PCR) -270.1000061035 (pr) 15.1000003815 (o) 10.8999996185 (d) 0 (u) 13.3000001907 (cts) -269.1000061035 (we) 15.8999996185 (re) -271.3999938965 (cl) 12.8000001907 (on) 13.3000001907 (e) 13.1000003815 (d) -273.1000061035 (di) 15.8000001907 (rec) 13.6000003815 (tl) 15.1000003815 (y) -276.1000061035 (i) 11.1999998093 (nt) 17.7999992371 (o) -278.299987793 (p) 0 (C) 16.2999992371 (R) 12.3999996185 (2.) 12.1999998093 (1-) ] TJ
0 -1.2264000177 TD
[(TO) 12.3000001907 (P) 12.3999996185 (O) -306.6000061035 (v) 12.6000003815 (ecto) 17.7999992371 (r) -301.799987793 (\() 0 (I) 12.8999996185 (n) 0 (v) 20.7999992371 (i) 0 (t) 15.1000003815 (r) 0 (o) 15.6999998093 (g) 0 (e) 17.7000007629 (n) 0 (/) 13.5 (L) 0 (i) 17.8999996185 (f) 0 (e) -245.5 (Tec) 15.3999996185 (hn) 11.1999998093 (o) 10.8999996185 (l) 0 (o) 16.3999996185 (g) 0 (i) 15.8999996185 (e) 0 (s) 16.2999992371 (\)) 0 (,) -298.799987793 (t) 0 (r) 20.1000003815 (a) 0 (n) 15.5 (s) 0 (f) 16.5 (o) 0 (r) 15.6999998093 (m) 0 (e) 13.1000003815 (d) ] TJ
T*
[(in) 13.6999998093 (to) -291.8999938965 (O) 11.6000003815 (n) 0 (e) 15.5 (S) 0 (h) 15.5 (o) 0 (t) -291.8999938965 (c) 0 (e) 14.6999998093 (l) 0 (l) 16.7000007629 (s) -303.3999938965 (\(I) 18.6000003815 (nv) 15 (i) 11.1999998093 (t) 0 (r) 14.3999996185 (o) 0 (g) 15.5 (e) 0 (n) 15.5 (/) 11.1000003815 (Li) 12.1000003815 (fe) -239.6999969482 (Tec) 15.3999996185 (hn) 11.1999998093 (o) 10.8999996185 (l) 0 (o) 16.3999996185 (g) 0 (i) 15.8999996185 (e) 0 (s) 16.2999992371 (\)) 0 (,) -293 (a) 0 (n) 15.5 (d) -302 (se) 16.2999992371 (-) ] TJ
0 -1.220600009 TD
[(qu) 13.3000001907 (en) 15.5 (ce) 14.6999998093 (d.) -425.3999938965 (Co) 16.7999992371 (rr) 15.3000001907 (ect) -438.5 (se) 10.5 (qu) 19.1000003815 (en) 15.5 (ce) 14.6999998093 (s) -436.5 (w) 0 (e) 15.8999996185 (r) 0 (e) -439.1000061035 (c) 0 (u) 16.1000003815 (t) -435.799987793 (fr) 18.1000003815 (om) -428.799987793 (th) 12.6000003815 (e) -438.1000061035 (p) 0 (C) 16.2999992371 (R) 12.3999996185 (2.) 12.1999998093 (1-) ] TJ
0 -1.2264000177 TD
[(TO) 12.3000001907 (P) 12.3999996185 (O) -474.3999938965 (vec) 15.6000003815 (to) 14.6999998093 (r) -475.3999938965 (a) 0 (n) 15.5 (d) -469.799987793 (l) 11.1999998093 (i) 0 (g) 15.8999996185 (a) 0 (t) 11.1999998093 (e) 0 (d) -462.5 (i) 11.1999998093 (nt) 12 (o) -469.200012207 (t) 0 (h) 12.6000003815 (e) -472.799987793 (do) 15.5 (ub) 13.8999996185 (l) 11.1999998093 (e) 0 (-) 58.9000015259 (T) 0 (7) -465.3999938965 (p) 0 (r) 15.1000003815 (o) 10.8999996185 (mo) 10.8999996185 (te) 16.8999996185 (r) ] TJ
T*
[(vec) 9.8999996185 (to) 20.5 (r) -290.299987793 (L) 0 (4) 14.8999996185 (4) 0 (4) 16.5 (0) -286.799987793 (\(A) 11.8000001907 (dd) 14.8999996185 (Ge) 17.3999996185 (ne) 15.5 (,) -291.1000061035 (C) 11.6999998093 (am) 13.1000003815 (br) 15.6999998093 (id) 15.8000001907 (ge) 17.7000007629 (,) -291.1000061035 (M) -16 (A) -20.8999996185 (,) -291.1000061035 (U) 11.6999998093 (S) 0 (A) 14.6999998093 (\)) -291.200012207 (us) 17.7000007629 (in) 13.6999998093 (g) -290.3999938965 (t) 0 (h) 18.3999996185 (e) ] TJ
0 -1.220600009 TD
[(Li) 17.8999996185 (ga) 12 (te) 16.8999996185 (-I) 14.3999996185 (T) -294.299987793 (K) 12.3000001907 (it) -285.799987793 (\(U) 15.5 (SB) 15.3999996185 (/A) 13.3000001907 (ff) 15.1000003815 (ym) 18.8999996185 (et) 11.1999998093 (ri) 21.7999992371 (x\)) -288.200012207 (as) -296.1000061035 (pe) 17.7000007629 (r) -296.1000061035 (t) 0 (h) 18.3999996185 (e) -293.5 (ki) 13.6999998093 (t) -291.200012207 (i) 11.1999998093 (ns) 11.3999996185 (tr) 20.1000003815 (uc) 10.3000001907 (ti) 20.7999992371 (on) 13.3000001907 (s.) ] TJ
/F8 1 Tf
0 -1.2264000177 TD
[(Esc) 14.6000003815 (he) 15.6000003815 (ric) 14.8999996185 (hi) 13.6999998093 (a) -296.299987793 (c) 12.6000003815 (ol) 14.3000001907 (i) ] TJ
/F7 1 Tf
6.6181001663 0 TD
[(st) 18.6000003815 (ra) 17.8999996185 (in) -287.200012207 (Ht) 10.1999998093 (11) 16.5 (5) -292.5 (\() 0 (D) 15.5 (E) 0 (3) 14.8999996185 (\)) 0 (,) -287.299987793 (w) 0 (h) 11.6000003815 (i) 11.1999998093 (ch) -290.5 (l) 11.1999998093 (a) 0 (c) 14.6999998093 (k) 0 (s) -300.8999938965 (R) 0 (N) 14.5 (ase) 12.1000003815 (II) 18.1000003815 (I,) ] TJ
-6.6181001663 -1.2264000177 TD
[(was) -420.6000061035 (tr) 20.1000003815 (an) 15.5 (sf) 16.5 (or) 15.6999998093 (me) 13.1000003815 (d) -423.5 (w) 0 (i) 14 (t) 0 (h) -415.5 (5) 0 (0) -411.6000061035 (n) 0 (g) -415.299987793 (o) 0 (f) -415.3999938965 (p) 0 (l) 15.8000001907 (asm) 10.5 (i) 11.1999998093 (d) -423.5 (DN) 13.8000001907 (A) -425.8999938965 (f) 13.3000001907 (or) -418.200012207 (ei) 18.6000003815 (th) 12.6000003815 (er) ] TJ
/F8 1 Tf
0 -1.220600009 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
3.0255999565 0 TD
-0.0109000001 Tc
(or) Tj
/F8 1 Tf
1.3710999489 0 TD
0 Tc
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
2.4586000443 0 TD
[(.) -487.799987793 (A) 0 (s) -486.299987793 (a) -484.3999938965 (co) 12.5 (nt) 17.7999992371 (ro) 15.6999998093 (l,) -476.5 (Ht) 16 (11) 16.5 (5) -489.200012207 (c) 0 (e) 14.6999998093 (l) 11.1999998093 (ls) -477.299987793 (we) 15.8999996185 (re) -479.6000061035 (tr) 14.3999996185 (an) 15.5 (s-) ] TJ
-6.8552999496 -1.2264000177 TD
[(fo) 12.6999998093 (rm) 16.2999992371 (ed) -294.700012207 (wi) 14 (th) -299.799987793 (L4) 14.8999996185 (44) 16.5 (0) -304.1000061035 (w) 0 (i) 14 (t) 0 (h) -299.799987793 (n) 0 (o) -299.1000061035 (i) 11.1999998093 (ns) 17.2000007629 (er) 12.1000003815 (t.) -298.799987793 (Bac) 11.8000001907 (te) 16.8999996185 (ri) 16 (al) -299.6000061035 (cu) 16.1000003815 (l) 11.1999998093 (t) 0 (u) 12.6000003815 (r) 0 (e) 17.8999996185 (s) -309.200012207 (we) 15.8999996185 (re) ] TJ
T*
[(ma) 13.1000003815 (i) 11.1999998093 (n) 0 (t) 12 (a) 13.1000003815 (in) 13.6999998093 (ed) -404.6000061035 (wi) 14 (th) -403.8999938965 (te) 16.8999996185 (tr) 14.3999996185 (ac) 14.6999998093 (yc) 14.6999998093 (li) 16.7000007629 (ne) -406.799987793 (\(1) 17.8999996185 (2.) 18 (5) ] TJ
/F11 1 Tf
14.7229003906 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
[(g/) 15.6999998093 (ml) 17 (\)) -412.700012207 (a) 0 (n) 15.5 (d) -417.700012207 (am) 18.8999996185 (pi) 15.8000001907 (ci) 12.8000001907 (l) 11.1999998093 (l) 0 (i) 16.7000007629 (n) ] TJ
-15.2551002502 -1.220600009 TD
[(\(AMP\)) -254 (\(1) 17.8999996185 (00) ] TJ
/F11 1 Tf
5.1545000076 0 TD
() Tj
/F7 1 Tf
0.5321999788 0 TD
[(g/) 15.6999998093 (ml) 17 (\).) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 56.6929016113 228.9259033203 Tm
[(RNAi) -302.6000061035 (by) -303.5 (feeding) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 216.9638061523 Tm
[(Overn) -7.5999999046 (ight) -712 (cultures) -714.200012207 (of) -710.5 (Ht11) -8 (5\(DE3) -7.5999999046 (\)) -707.700012207 (transforme) -11.6999998093 (d) -707 (with) ] TJ
0 -1.2264000177 TD
[(RNAi) -377 (or) -371.8999938965 (control) -376.700012207 (pla) -17.3999996185 (smids) -371.299987793 (wer) -8.3000001907 (e) -368.700012207 (used) -375.299987793 (to) -372.8999938965 (inoc) -8.6000003815 (ulate) -372.200012207 (50) -371.1000061035 (ml) ] TJ
T*
[(of) -461.700012207 (LB) -7.8000001907 (-A) -21.3999996185 (MP) -466.3999938965 (\(100) ] TJ
/F11 1 Tf
7.769299984 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
[(g/mL\)) -471.3999938965 (and) -465.799987793 (grown) -466.200012207 (until) -465.799987793 (the) -466 (595-n) -8 (m) ] TJ
-8.3130998611 -1.220600009 TD
[(optical) -336.8999938965 (density) -336.1000061035 (reached) -334.3999938965 (0.3) -332.3999938965 (to) -326.6000061035 (0.4,) -334.200012207 (at) -330.200012207 (which) -331.299987793 (poi) -8 (nt) -329.299987793 (isopro-) ] TJ
0 -1.2264000177 TD
(pyl) Tj
/F11 1 Tf
1.9379999638 0 TD
() Tj
/F7 1 Tf
0.5264000297 0 TD
[(-D-1-th) -9.3999996185 (iogalactop) -13.3000001907 (yranoside) -710.4000244141 (\(IP) -15.1999998093 (TG\)) -702.700012207 (\(RPI,) -704.700012207 (Mount) ] TJ
-2.464400053 -1.2264000177 TD
[(Prospe) -20.5 (ct) -12 (,) -320 (I) 0 (L) -24.7999992371 (,) -320 (USA\)) -322.700012207 (wa) -13 (s) -320.799987793 (added) -324.6000061035 (to) -320.799987793 (a) -322.3999938965 (final) -324.700012207 (concent) -10.5 (ration) -324 (of) ] TJ
0 -1.220600009 TD
[(0.125) -408.3999938965 (mg) -7 (/ml.) -407.6000061035 (Cultur) -8.8000001907 (es) -406 (were) -411.700012207 (incuba) -9.8000001907 (ted) -406.6000061035 (with) -413 (shaking) -422.799987793 (for) ] TJ
0 -1.2264000177 TD
[(3) -523.9000244141 (hours) -524.799987793 (at) -526.9000244141 <3337B043> -523.799987793 (to) -529.0999755859 (induce) -525.299987793 (the) -529.5999755859 (production) -532.4000244141 (of) -525.4000244141 (double) -9.8999996185 (-) ] TJ
T*
[(strand) -8.6000003815 (ed) -456.700012207 (RNA.) -459.5 (Para) -8.6999998093 (me) -15.8999996185 (cia) -454.200012207 (tha) -9 (t) -453.200012207 (had) -459.5 (re) -16.7999992371 (cently) -463.799987793 (underg) -8 (one) ] TJ
0 -1.220600009 TD
[(autogamy) -557.4000244141 (wer) -8.3000001907 (e) -553.799987793 (colle) -21.3999996185 (cted) -549.700012207 (by) -548.700012207 (centr) -9.1000003815 (ifugation) -556.9000244141 (and) -546.799987793 (resus) -19.1000003815 (-) ] TJ
0 -1.2264000177 TD
[(pende) -8.5 (d) -498.700012207 (i) 0 (n) -501.200012207 (1) 0 (0) -504.1000061035 (m) 0 (l) -497.8999938965 (o) 0 (f) -502.200012207 (D) 0 (r) -6.6999998093 (y) 0 (l) ] TJ
/F10 1 Tf
11.0840997696 0 TD
<92> Tj
/F7 1 Tf
0.1387999952 0 TD
[(s) -500.1000061035 (solution) -510.200012207 (\(1) -497 (mM) -507.700012207 (Na) ] TJ
7.3499999046 0 0 6.5324001312 260.2770996094 95.3007965088 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 263.962097168 96.9449005127 Tm
(HPO) Tj
7.3499999046 0 0 6.5324001312 284.7117004395 95.3007965088 Tm
(4) Tj
9.7999000549 0 0 9.7999000549 288.3967895508 96.9449005127 Tm
(,) Tj
-23.6434001923 -1.2264000177 TD
[(1) -622.299987793 (m) 0 (M) -623.4000244141 (NaH) ] TJ
7.3499999046 0 0 6.5324001312 110.4944992065 83.3386001587 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 114.1794967651 84.9260025024 Tm
(PO) Tj
7.3499999046 0 0 6.5324001312 127.3322982788 83.3386001587 Tm
(4) Tj
9.7999000549 0 0 9.7999000549 131.0173034668 84.9260025024 Tm
[(,) -620.799987793 (1.5) -627.4000244141 (mM) -623.4000244141 (CaCl) ] TJ
7.3499999046 0 0 6.5324001312 200.9196014404 83.3386001587 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 204.6047058105 84.9260025024 Tm
[(,) -620.799987793 (2) -622.299987793 (mM) -623.4000244141 (Na-) -8.3000001907 (citrate,) ] TJ
-15.0930995941 -1.220600009 TD
[(pH) -428.700012207 (6.8\)) -426.8999938965 (to) -424.8999938965 (purge) -427 (bac) -9.1000003815 (teria) -428.299987793 (from) -428.1000061035 (their) -426.8999938965 (surfa) -8.8999996185 (ces) -427.6000061035 (and) -425.3999938965 (food) ] TJ
0 -1.2264000177 TD
[(vacuol) -11.3000001907 (es.) ] TJ
26.1252002716 64.8964004517 TD
[(The) -382.3999938965 (induced) -393.5 (bacter) -10.6000003815 (ia) -386.3999938965 (were) -400.1000061035 (colle) -21.3999996185 (cted) -387.700012207 (by) -392.5 (centrifu) -10.3999996185 (gation) ] TJ
-0.8156999946 -1.220600009 TD
[(at) -671.5 (4,000) -200.1999969482 ] TJ
/F8 1 Tf
4.6454000473 0 TD
(g) Tj
/F7 1 Tf
1.081799984 0 TD
[(\(Be) -14.8000001907 (ckm) -7.5999999046 (an) -667.0999755859 (J2-2) -7.5 (1) -668.5999755859 (centrifu) -10.3999996185 (ge,) -666.700012207 (JA-1) -7.6999998093 (4) -668.5999755859 (rotor;) ] TJ
-5.7272000313 -1.2264000177 TD
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T*
[(pende) -8.5 (d) -377.299987793 (i) 0 (n) -379.700012207 (100) -380.1000061035 (mL) -381 (of) -380.700012207 (whe) -10 (at) -376.3999938965 (cult) -9.3000001907 (ure) -378.299987793 (mediu) -8.6000003815 (m) -381.8999938965 (containing) ] TJ
0 -1.220600009 TD
[(an) -360.5 (addit) -9 (ional) -367.6000061035 (8) ] TJ
/F11 1 Tf
6.728000164 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
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-7.2718000412 -1.2264000177 TD
[(\(RPI\),) -359.6000061035 (and) -355.8999938965 (100) ] TJ
/F11 1 Tf
6.473400116 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
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-7.0171999931 -1.2264000177 TD
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0 -1.220600009 TD
[(In) -306.700012207 (the) -315.6000061035 (ca) -14.3000001907 (se) -307.700012207 (of) -305.5 (the) ] TJ
/F8 1 Tf
7.6015000343 0 TD
(MKS3) Tj
/F7 1 Tf
2.8694000244 0 TD
(and) Tj
/F8 1 Tf
1.839599967 0 TD
[(IF) -9 (T88) ] TJ
/F7 1 Tf
2.8057000637 0 TD
[(RNAi) -307.6000061035 (cult) -9.3000001907 (ures) -22.2000007629 (,) -308.3999938965 (4,000) ] TJ
-15.1162996292 -1.2264000177 TD
[(and) -367.5 (8,000) -362.1000061035 (cel) -8.8000001907 (ls) -361.6000061035 (were) -365.3999938965 (added) -370.799987793 (to) -361.299987793 (10) -6.5999999046 (0) -362 (ml,) -360.8999938965 (res) -7.9000000954 (pe) -11.3000001907 (ctivel) -10.1000003815 (y.) -364.700012207 (Cul-) ] TJ
T*
[(tures) -463.8999938965 (wer) -8.3000001907 (e) -461.299987793 (maintain) -12.1000003815 (ed) -462.5 (at) -463.200012207 <3238B043> -20.5 (,) -464.6000061035 (and) -465.799987793 (after) -466.700012207 (24) -457.799987793 (hours) -27.2000007629 (,) -464.6000061035 (a) 0 (n) ] TJ
0 -1.220600009 TD
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/F11 1 Tf
21.5202999115 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
0.5044999719 Tc
[(go) 504.5 (f) ] TJ
-22.0641002655 -1.2264000177 TD
0 Tc
[(stigma) -16.1000003815 (ste) -8.8000001907 (rol) -401.200012207 (wer) -8.3000001907 (e) -403.3999938965 (added.) -407.3999938965 (Growth) -415.8999938965 (rates) -407.5 (of) -403.8999938965 (culture) -11.6000003815 (s) -401.799987793 (were) ] TJ
T*
[(determin) -10.6999998093 (ed) -393.1000061035 (by) -398.299987793 (countin) -10.8999996185 (g) -394.5 (cells) -399.299987793 (at) -393.799987793 (24,) -396 (48) -394.200012207 (an) -7.5999999046 (d) -394.6000061035 (7) 0 (2) -394.200012207 (hours) -397.5 (of) ] TJ
0 -1.220600009 TD
[(growth) -10.6000003815 (.) -493.6000061035 (All) -490.200012207 (exp) -8.1999998093 (eriment) -15.1999998093 (s) -494.299987793 (wer) -8.3000001907 (e) -490.200012207 (repea) -9.1999998093 (ted) -493.3999938965 (a) -496 (minimum) -498.700012207 (of) ] TJ
0 -1.2264000177 TD
[(three) -436.6000061035 (time) -434.700012207 (and) -431.1000061035 (all) -433 (culture) -11.6000003815 (s) -430.700012207 (were) -434.799987793 (har) -31.2000007629 (veste) -12.1000003815 (d) -429.299987793 (o) 0 (r) -429.799987793 (obser) -38.0999984741 (ved) ] TJ
T*
[(after) -570.9000244141 (appr) -7.6999998093 (oximat) -10 (ely) -570 (72) -567.700012207 (hours) -571 (of) -571.5999755859 (growth) -571.799987793 (unless) -577.0999755859 (noted) ] TJ
0 -1.220600009 TD
[(otherwise) -15.1000003815 (.) ] TJ
/F5 1 Tf
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[(Immuno) -9.8000001907 (fluorescence) ] TJ
/F7 1 Tf
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[(Cultur) -8.8000001907 (ed) -375.700012207 (cells) -382 (\(100) -376.299987793 (ml\)) -378.3999938965 (were) -388.5 (colle) -15.6000003815 (cted) -381.8999938965 (by) -375.1000061035 (ce) -8.5 (ntrifugation) ] TJ
0 -1.2264000177 TD
[(\(Damon) -733.299987793 (IEC) -730.5 (Divis) -8 (ion) -727.5 (Clinic) -8.3999996185 (al) -727.700012207 (Centrif) -9 (uge,) -727.4000244141 (Ne) -7.9000000954 (edham) ] TJ
T*
[(Height) -21.5 (s) -20 (,) -337.3999938965 (M) -21.7000007629 (A) -32.5 (,) -343.200012207 (USA\)) -340.1000061035 (an) -7.5999999046 (d) -336.799987793 (rinsed) -342.5 (twic) -9.5 (e) -339.799987793 (i) 0 (n) -339.200012207 (100) -339.700012207 (ml) -341.700012207 (of) -340.200012207 (Dryl) ] TJ
/F10 1 Tf
23.3425998688 0 TD
<92> Tj
/F7 1 Tf
0.133100003 0 TD
(s) Tj
-23.4755992889 -1.220600009 TD
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0 -1.2264000177 TD
(100) Tj
/F11 1 Tf
1.828099966 0 TD
() Tj
/F7 1 Tf
0.5379999876 0 TD
[(l) -324.299987793 (i) 0 (n) -327.700012207 (a) -322.3999938965 (1.5) -8.3999996185 (-ml) -324.799987793 (Eppendo) -11.1000003815 (rf) -323.200012207 (tube) -327.799987793 (bef) -8.8999996185 (ore) -324.1000061035 (1) -327.299987793 (m) 0 (l) -324.299987793 (o) 0 (f) -328.700012207 (PHE) -20.8999996185 (M) ] TJ
-2.3661000729 -1.2264000177 TD
[(and) -425.3999938965 (0.1%) -422.200012207 (or) -424 (0.5%) -422.200012207 (Trito) -9.1000003815 (n) -419.8999938965 (X) 33.2999992371 (-10) -7.0999999046 (0\)) -421.799987793 (wa) -13 (s) -419.1000061035 (added.) -430.5 (Cells) -423.8999938965 (were) ] TJ
0 -1.220600009 TD
[(undistu) -9.3000001907 (rbed) -522 (for) -520.5999755859 (1) -518.200012207 (t) 0 (o) -523.299987793 (4) -518.200012207 (minut) -8.5 (es) -24.2000007629 (,) -516.700012207 (the) -9 (n) -518.200012207 (spun) -519.0999755859 (at) -521.0999755859 (25) -6.5999999046 (0) -194.1999969482 ] TJ
/F8 1 Tf
23.4466991425 0 TD
(g) Tj
/F7 1 Tf
-23.4466991425 -1.2264000177 TD
[(\(Damon) -415.200012207 (IEC) -406.5 (Divisio) -9 (n) -402.5 (Clinic) -8.3999996185 (al) -403.700012207 (Cen) -7.5 (trifuge\)) -410.8999938965 (and) -408 (then) -411.5 (the) ] TJ
T*
[(supern) -9.5 (atant) -669.5 (wa) -13 (s) -667.9000244141 (remove) -9.1999998093 (d) -666.5 (and) -668.299987793 (the) -668.5 (pellet) -671.799987793 (\(cells\)) -663.5999755859 (wa) -13 (s) ] TJ
0 -1.220600009 TD
[(mixed) -297.799987793 (with) -297.299987793 (1) -292.5 (m) 0 (l) -295.3999938965 (o) 0 (f) -294 (fixation) -301.1000061035 (buffer) -294.5 (\(2%) -297.5 (or) -296.700012207 (4%) -289.799987793 (paraf) -9 (ormal-) ] TJ
0 -1.2264000177 TD
[(dehyde) -694.799987793 (\(Ele) -11.5 (ctron) -693.9000244141 (Microsc) -11.6999998093 (opy) -688.799987793 (S) -10.6999998093 (ciences) -29 (,) -684.5 (Hatf) -9.6999998093 (ield,) -690.5999755859 (P) 52.9000015259 (A) -32.5 (,) ] TJ
T*
[(USA\),) -336.1000061035 (2) -333 (m) 0 (M) -334.200012207 (NaH) ] TJ
7.3499999046 0 0 6.5324001312 380.5227966309 335.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 384.2077941895 336.9259033203 Tm
(PO) Tj
7.3499999046 0 0 6.5324001312 397.4172058105 335.3385009766 Tm
(4) Tj
/F10 1 Tf
9.7999000549 0 0 9.7999000549 401.1022949219 336.9259033203 Tm
<80> Tj
/F7 1 Tf
0.3934000134 0 TD
(H) Tj
7.3499999046 0 0 6.5324001312 412.5541992188 335.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 416.2392883301 336.9259033203 Tm
[(O,) -331.6000061035 (8) -333 (m) 0 (M) -334.200012207 (N) 0 (a) ] TJ
7.3499999046 0 0 6.5324001312 469.8140869141 335.3385009766 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 473.4991149902 336.9259033203 Tm
(HPO) Tj
7.3499999046 0 0 6.5324001312 494.2486877441 335.3385009766 Tm
(4) Tj
9.7999000549 0 0 9.7999000549 497.933807373 336.9259033203 Tm
[(,) -331.6000061035 (150) -333.8999938965 (mM) ] TJ
-19.7154006958 -1.220600009 TD
[(NaCl) -8.1000003815 (,) -308.3999938965 (p) 0 (H) -313 (7.5\).) -313.1000061035 (Sample) -9.1999998093 (s) -309.200012207 (were) -313.299987793 (und) -7.4000000954 (isturbed) -315.700012207 (for) -312.299987793 (10) -313.200012207 (minut) -8.5 (es) ] TJ
0 -1.2264000177 TD
[(or) -545.5 (rocked) -546.9000244141 (for) -549.5 (1) -541.299987793 (hour) -551.0999755859 (at) -544.200012207 (room) -546.200012207 (tempe) -11.6999998093 (rature) -547.5 (\(R) 16.2000007629 (T) -10.8000001907 (\)) -545.799987793 (and) ] TJ
T*
[(wa) -13 (shed) -462.1000061035 (three) -459.700012207 (times) -460.3999938965 (in) -454.8999938965 (1) -454.5 (m) 0 (l) -457.3999938965 (o) 0 (f) -484.8999938965 (block) -9.1999998093 (ing) -456.1000061035 (buffe) -10 (r) -452.299987793 (\() 0 (2) -456.5 (m) 0 (M) ] TJ
0 -1.220600009 TD
(NaH) Tj
7.3499999046 0 0 6.5324001312 324.1700134277 287.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 327.8550109863 288.9637145996 Tm
(PO) Tj
7.3499999046 0 0 6.5324001312 341.0078125 287.3196105957 Tm
(4) Tj
/F10 1 Tf
9.7999000549 0 0 9.7999000549 344.6928100586 288.9637145996 Tm
<80> Tj
/F7 1 Tf
0.3991999924 0 TD
(H) Tj
7.3499999046 0 0 6.5324001312 356.1448059082 287.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 359.8298034668 288.9637145996 Tm
[(O,) -846.4000244141 (8) -836.299987793 (m) 0 (M) -843.299987793 (N) 0 (a) ] TJ
7.3499999046 0 0 6.5324001312 428.4281921387 287.3196105957 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 432.1133117676 288.9637145996 Tm
(HPO) Tj
7.3499999046 0 0 6.5324001312 452.8629150391 287.3196105957 Tm
(4) Tj
9.7999000549 0 0 9.7999000549 456.5479125977 288.9637145996 Tm
[(,) -840.700012207 (150) -843 (mM) -837.5 (Na) -7.9000000954 (Cl,) ] TJ
-15.4923000336 -1.2264000177 TD
[(10) -342.1000061035 (mM) -351.5 (EGT) 57.9000015259 (A) -32.5 (,) -343.200012207 (2) -344.6000061035 (m) 0 (M) -345.799987793 (MgCl) ] TJ
7.3499999046 0 0 6.5324001312 421.8518981934 275.3008117676 Tm
(2) Tj
9.7999000549 0 0 9.7999000549 425.536895752 276.9448852539 Tm
[(,) -343.200012207 (0.1%) -347 (Tw) -8.1000003815 (een) -347.3999938965 (20,) -344 (1%) -347.6000061035 (or) -343 (3%) ] TJ
-12.3278999329 -1.2264000177 TD
[(bovine) -309.1000061035 (serum) -305.799987793 (albumin) -312.6000061035 (\(BSA\),) -306.299987793 (pH) -301.5 (7.5\).) ] TJ
0.8156999946 -1.220600009 TD
[(Primary) -409.200012207 (antibodi) -12.8000001907 (es) -400.200012207 (for) -404.8999938965 (the) -402.3999938965 (immunos) -9.8999996185 (taining) -413.8999938965 (for) -404.8999938965 (loca) -9.5 (li-) ] TJ
-0.8156999946 -1.2264000177 TD
[(z) -14.1999998093 (ation) -351.8999938965 (were) -353.799987793 (a) -10 (s) -349.700012207 (follows) -23.2000007629 (:) -348.8999938965 (F) 0 (L) -34.5 (AG-MKS3:) -354.799987793 (mou) -9.3000001907 (se) -348.200012207 (anti-FL) -39.0999984741 (AG,) ] TJ
T*
[(M2) -418.3999938965 (clon) -8.6000003815 (e) -415 (a) 0 (t) -422.700012207 (a) -420.799987793 (1:300) -420 (dilution) -427.5 (\(Sigm) -8.3999996185 (a-Aldrich\)) -425.1000061035 (an) -7.5999999046 (d) -417.799987793 (anti-) ] TJ
0 -1.220600009 TD
[(centr) -9.1000003815 (in) -420.200012207 (at) -422.700012207 (a) -420.799987793 (1:1,0) -7.8000001907 (00) -423.1000061035 (dilution) -427.5 (\(anti-) ] TJ
/F8 1 Tf
14.705499649 0 TD
[(Te) -7.6999998093 (trahymena) ] TJ
/F7 1 Tf
5.9759001732 0 TD
(centrin,) Tj
-20.6814994812 -1.2264000177 TD
[(gift) -395.1000061035 (from) -393.3999938965 (Mark) -394.799987793 (Winey,) -398.200012207 (University) -398.8999938965 (of) -392.299987793 (Color) -8.3000001907 (ado,) -389.799987793 (Boulde) -12.1000003815 (r) 74.1999969482 (,) ] TJ
T*
[(CO,) -528.0999755859 (USA) -8.3999996185 (\).) -524.5 (For) -534.5999755859 (ciliary) -529.5999755859 (mea) -20.1000003815 (surement) -20.2999992371 (s) -20 (,) -528.299987793 (we) -527.9000244141 (used) -531.5 (mou) -9.3000001907 (se) ] TJ
0 -1.220600009 TD
(anti-) Tj
/F11 1 Tf
1.9495999813 0 TD
() Tj
/F7 1 Tf
0.5554000139 0 TD
[(-tubulin) -319.299987793 (at) -312.799987793 (a) -305.1000061035 (dil) -7.6999998093 (ution) -309.8999938965 (of) -311.299987793 (1:200) -315.8999938965 (\(Sigm) -8.3999996185 (a-Aldrich\).) -317.1000061035 (For) ] TJ
-2.5048999786 -1.2264000177 TD
[(visua) -9 (liz) -9.1000003815 (ation) -467.6000061035 (of) -490.6000061035 (ba) -16.5 (sal) -458.3999938965 (bodi) -8.6999998093 (es) -18.3999996185 (,) -458.8999938965 (w) 0 (e) -464.200012207 (used) -462.1000061035 (anti-ce) -13.1000003815 (ntrin) -461.299987793 (at) -457.3999938965 (a) ] TJ
T*
[(dilution) -566.4000244141 (of) -560.0999755859 (1:1,0) -7.8000001907 (00.) -558 (For) -563.5 (cortical) -566.5999755859 (unit) -563.799987793 (visualiz) -18.1000003815 (ation,) -562 (we) ] TJ
0 -1.220600009 TD
[(used) -560.4000244141 (anti-2F1) -11.8000001907 (2) -552.9000244141 (a) 0 (t) -555.799987793 (a) -553.799987793 (dil) -7.6999998093 (ution) -558.700012207 (of) -554.299987793 (1:200) -558.799987793 (\() -13.5 (gift) -557.0999755859 (from) -561.0999755859 (Jean) ] TJ
0 -1.2264000177 TD
[(Cohen,) -469.799987793 (Gif-s) -8.8999996185 (ur) 19.2999992371 (-) 51.5999984741 (Y) 52.2999992371 (vette,) -470.299987793 (Fran) -9.3000001907 (ce\).) -463.5 (For) -470.8999938965 (the) -477.6000061035 (visualiz) -18.1000003815 (ation) -467.6000061035 (of) ] TJ
T*
[(the) -437.1000061035 (kinetod) -9.3000001907 (esmal) -439.6000061035 (fibers) -435.200012207 (\(KDFs\),) -430.5 (we) -435.299987793 (use) -9.6000003815 (d) -429.299987793 (anti-K) -9.6000003815 (DF) -411.299987793 (at) -434.299987793 (a) ] TJ
0 -1.220600009 TD
[(1:400) -709.200012207 (dilution) -711 (\() -13.5 (gift) -707.5 (from) -705.799987793 (Janine) -704.4000244141 (Beisson,) -712.700012207 (Centre) -708.9000244141 (de) ] TJ
0 -1.2264000177 TD
[<47E96EE974> -9.5 (ique) -349.8999938965 <4D6F6CE9> -9.6000003815 (culaire,) -354.6000061035 (Gif-s) -8.8999996185 (ur) 19.2999992371 (-) 51.5999984741 (Y) 52.2999992371 (vette) -11.3999996185 (,) -348.8999938965 (France\)) -355.299987793 (and) -350.200012207 (an) -7.5999999046 (ti-) ] TJ
T*
(Glu-) Tj
/F11 1 Tf
1.9091000557 0 TD
() Tj
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T*
[(46) 16.5 (3) -263.6000061035 (b) 10.8999996185 (asa) 12.1000003815 (l) -260.700012207 (b) 0 (o) 10.3000001907 (d) 0 (i) 21.6000003815 (e) 0 (s) -255.6000061035 (w) 0 (e) 15.8999996185 (r) 0 (e) -254 (a) 0 (n) 15.5 (a) 0 (l) 12.8000001907 (y) 0 (z) 16.2000007629 (e) 0 (d) -254.1999969482 (o) 0 (n) -252.8000030518 (t) 0 (h) 12.6000003815 (e) 0 (s) 16.2999992371 (e) -264.6000061035 (th) 18.3999996185 (re) 17.8999996185 (e) -276.1000061035 (c) 0 (e) 14.6999998093 (l) 11.1999998093 (ls) 14.3999996185 (.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 56.6929016113 276.9448852539 Tm
[(Scanning) -311.6000061035 (electron) -307.200012207 (microscopy) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 264.9259033203 Tm
[(RNAi) -296 (cult) -9.3000001907 (ured) -292.799987793 (cells) -295.200012207 (\(20) -8.6000003815 (0) -286.799987793 (ml\)) -297.3999938965 (were) -307.5 (colle) -15.6000003815 (cted) -300.8999938965 (by) -294.1000061035 (brief) -293.799987793 (cen-) ] TJ
0 -1.220600009 TD
[(trifuga) -9.8000001907 (tion) -312.8999938965 (at) -312.799987793 (800) -200.8000030518 ] TJ
/F8 1 Tf
8.255200386 0 TD
(g) Tj
/F7 1 Tf
0.7289000154 0 TD
[(\(Damon) -322.6000061035 (IEC) -308.1000061035 (Divis) -8 (ion) -311 (Clin) -9.6999998093 (ical) -310 (Cen) -7.5 (-) ] TJ
-8.9841003418 -1.2264000177 TD
[(trifuge) -9.8000001907 (\),) -553.4000244141 (wa) -13 (shed) -560.4000244141 (twice) -557.5999755859 (in) -559.0999755859 (Dryl) ] TJ
/F10 1 Tf
13.3576002121 0 TD
<92> Tj
/F7 1 Tf
0.133100003 0 TD
[(s) -552.200012207 (solution) -562.299987793 (an) -7.5999999046 (d) -550.799987793 (fixed) -562.0999755859 (a) -10 (s) ] TJ
-13.4906997681 -1.2264000177 TD
[(describe) -12.8000001907 (d) -458.200012207 (b) 0 (y) -461.8999938965 (Lieberman) ] TJ
/F8 1 Tf
10.7544002533 0 TD
[(et) -471.1000061035 (al) ] TJ
/F7 1 Tf
2.0248000622 0 TD
[(.) -458.799987793 ([) 3.7999999523 (32) -6.5999999046 (].) -460.799987793 (After) -460.299987793 (critica) -10.6000003815 (l) -457.299987793 (point) ] TJ
-12.7791004181 -1.220600009 TD
[(drying) -28.7000007629 (,) -424.1000061035 (cover) -9.1999998093 (slips) -429.3999938965 (were) -429 (glued) -432.1000061035 (onto) -429 (an) -429.8999938965 (aluminum) -430.5 (chu) -9.8000001907 (ck) ] TJ
0 -1.2264000177 TD
[(using) -392.1000061035 (colloida) -12 (l) -382.1000061035 (grap) -7.6999998093 (hite) -402.700012207 (cement) -394.1000061035 (and) -390.6000061035 (allowed) -395.799987793 (to) -390.200012207 (dry) -388.299987793 (in) -385.5 (a) ] TJ
T*
[(desicc) -11.1000003815 (ator) -517 (overni) -8.6000003815 (ght.) -516.799987793 (T) 12.3000001907 (h) 0 (e) -516.0999755859 (samp) -8.1000003815 (les) -516.200012207 (were) -521.5999755859 (sputter) 13.1000003815 (-coated) ] TJ
0 -1.220600009 TD
[(an) 15.5 (d) -325.200012207 (s) 0 (t) 18.6000003815 (o) 0 (r) 15.6999998093 (e) 0 (d) -317.8999938965 (i) 11.1999998093 (n) -321.5 (a) -322.3999938965 (de) 11.8999996185 (si) 20.2000007629 (cc) 14.6999998093 (at) 11.1999998093 (o) 10.8999996185 (r) -325 (un) 17 (ti) 15.1000003815 (l) -318.5 (i) 0 (m) 11.1999998093 (a) 0 (g) 17.7000007629 (e) 0 (d) -317.8999938965 (u) 0 (s) 17.7000007629 (i) 11.1999998093 (ng) -316.8999938965 (a) -322.3999938965 (J) 0 (S) 12.1000003815 (M) 18.7000007629 (-) 11.1000003815 (6) 0 (0) 16.5 (6) 0 (0) ] TJ
0 -1.2264000177 TD
[(sc) 16.2999992371 (an) 15.5 (ni) 13.6999998093 (ng) -316.8999938965 (el) 12.8000001907 (ect) 12.6999998093 (ro) 15.6999998093 (n) -327.299987793 (m) 0 (i) 17 (c) 0 (r) 17.8999996185 (o) 0 (s) 14.1000003815 (c) 0 (o) 12.5 (p) 0 (e) -317.8999938965 (\() -48.2000007629 (J) 11.1999998093 (E) 0 (O) 12.3999996185 (L) -317.299987793 (US) 18.2999992371 (A) -26.7000007629 (,) -325.799987793 (Pe) 14 (ab) 12.5 (o) 10.8999996185 (d) 0 (y) 11.8999996185 (,) -325.799987793 (M) -16 (A) -20.8999996185 (,) ] TJ
T*
[(US) 18.2999992371 (A\)) 11.8000001907 (.) ] TJ
/F5 1 Tf
9.2000999451 0 0 9.2000999451 56.6929016113 132.9447937012 Tm
[(Transm) -9.3000001907 (ission) -304.700012207 (electron) -307.200012207 (microscopy) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 120.9260025024 Tm
[(RNAi) -296 (cult) -9.3000001907 (ured) -292.799987793 (cells) -295.200012207 (\(10) -8.6000003815 (0) -286.799987793 (ml\)) -297.3999938965 (were) -307.5 (colle) -15.6000003815 (cted) -300.8999938965 (by) -294.1000061035 (brief) -293.799987793 (cen-) ] TJ
0 -1.220600009 TD
[(trifuga) -9.8000001907 (tion) -312.8999938965 (at) -312.799987793 (800) -200.8000030518 ] TJ
/F8 1 Tf
8.255200386 0 TD
(g) Tj
/F7 1 Tf
0.7289000154 0 TD
[(\(Damon) -322.6000061035 (IEC) -308.1000061035 (Divis) -8 (ion) -311 (Clin) -9.6999998093 (ical) -310 (Cen) -7.5 (-) ] TJ
-8.9841003418 -1.2264000177 TD
[(trifuge) -9.8000001907 (\)) -430.1000061035 (and) -436.8999938965 (wa) -13 (shed) -439 (twice) -436.1000061035 (in) -431.799987793 (10) -6.5999999046 (0) -431.3999938965 (m) 0 (l) -428.5 (o) 0 (f) -438.6000061035 (Dryl) ] TJ
/F10 1 Tf
19.3220005035 0 TD
<92> Tj
/F7 1 Tf
0.133100003 0 TD
[(s) -430.700012207 (solution) -12.6999998093 (,) ] TJ
-19.4550991058 -1.2264000177 TD
[(then) -550.4000244141 (approxim) -11.5 (ately) -547.200012207 (100) ] TJ
/F11 1 Tf
10.9279003143 0 TD
() Tj
/F7 1 Tf
0.5437999964 0 TD
[(L) -542.9000244141 (o) 0 (f) -548.5 (the) -558.5999755859 (cell) -547.0999755859 (pellet) -550.299987793 (wa) -13 (s) -546.4000244141 (re-) ] TJ
-11.4716997147 -1.220600009 TD
[(moved) -323.3999938965 (an) -7.5999999046 (d) -313.6000061035 (p) 0 (l) -7.3000001907 (aced) -320.5 (in) -321.8999938965 (1.5-ml) -321.700012207 (Epp) -7.4000000954 (endorf) -327 (tubes.) -326.5 (One) -320 (milli-) ] TJ
0 -1.2264000177 TD
[(liter) -343.3999938965 (of) -334.3999938965 (Fixat) -9.8999996185 (ion) -339.8999938965 (Solution) -344.700012207 (A) -333.299987793 (\(1%) -343.799987793 (gluteral) -10.3000001907 (dehyde) -341.8999938965 (\(Ele) -17.2000007629 (ctron) ] TJ
25.3094997406 64.8964004517 TD
[(Microsc) -11.6999998093 (opy) -931.700012207 (S) -10.6999998093 (cie) -8.8000001907 (nces\),) -938.0999755859 (0.05) -931.5999755859 (M) -930 (sodium) -939.0999755859 (ca) -8.5 (codylate,) ] TJ
0 -1.220600009 TD
0.0203000009 Tc
[(pH) -389.799987793 (7.2\)) -380.799987793 (w) -5.8000001907 (a) -7.0999999046 (s) -387.299987793 (a) -1.2999999523 (dded,) -380.700012207 (r) -3.9000000954 (ocked) -385.8999938965 (f) -1.1000000238 (or) -385.700012207 (30) -382.200012207 (minu) -5.5999999046 (tes) -381.5 (o) -3.5 (n) -382.200012207 (i) -3.2000000477 (ce) -383.1000061035 (and) ] TJ
0 -1.2264000177 TD
0.0208999999 Tc
[(wa) -12.3000001907 (shed) -529.9000244141 (three) -527.0999755859 (t) -4.1999998093 (imes) -525.5 (for) -529.700012207 (1) 0.200000003 (0) -526.200012207 (m) 3.5 (inutes) -525.5 (under) -523.9000244141 (t) 1.6000000238 (he) -527.0999755859 (same) ] TJ
T*
0.0218000002 Tc
[(co) 3.7999999523 (ndi) 4.0999999046 (t) 2.5 (io) 3.7999999523 (ns.) -344.5 (C) -1.2000000477 (el) 4.0999999046 (l) 4.0999999046 (s) -345.299987793 (wer) 3.4000000954 (e) -346.8999938965 (r) 3.4000000954 (e) 0.200000003 (suspe) 6 (n) 1.1000000238 (ded) -338.1000061035 (i) -1.7000000477 (n) -340.200012207 (p) 3.2000000477 (ostfix) -339.6000061035 (So) 3.7999999523 (lutio) 3.7999999523 (n) ] TJ
0 -1.220600009 TD
0.0203000009 Tc
[(B) -399.1000061035 (\() 1 (1%) -405 (gluteraldehyde) -400.5 (\(Ele) -12.8999996185 (ct) ] TJ
12.252699852 0 TD
0.0209999997 Tc
[(ron) -398.8999938965 (M) -0.6999999881 (ic) 5.1999998093 (roscopy) -399.799987793 (S) -12.8000001907 (ciences\),) ] TJ
-12.252699852 -1.2264000177 TD
0.0212999992 Tc
[(0.05) -421.700012207 (M) -417 (s) 1.2999999523 (odium) -418.3999938965 (cacody) 5.5 (late) -422.6000061035 (buffer) 72.3000030518 (,) -414.3999938965 (1%) -421.3999938965 (osmium) -418.3999938965 (te) 5.5 (trox-) ] TJ
T*
0.0208999999 Tc
[(ide,) -333.799987793 (pH) -337.200012207 (7.2\)) -334 (and) -339 (a) -0.6999999881 (gain) -341.1000061035 (wa) -12.3000001907 (shed) -333.200012207 (and) -339 (r) 2.5 (insed) -333.200012207 (a) -12.3000001907 (s) -334.6000061035 (d) -3.5 (escribed) ] TJ
0 -1.220600009 TD
0.0104999999 Tc
[(above.) -321.1000061035 (C) 10.5 (e) -10.8999996185 (l) 10.5 (l) -7.5 (s) -321.799987793 (w) 1.7000000477 (ere) -317.700012207 (p) -2.2999999523 (reembedde) -5.3000001907 (d) -314.700012207 (in) -322.6000061035 (2%) -322.200012207 (agarose) -317.700012207 (g) -2.2000000477 (el) -319.6000061035 (\(Invi-) ] TJ
0 -1.2264000177 TD
0.0115 Tc
[(troge) -4.3000001907 (n) 2.4000000954 (/) 11.5 (L) -5.5 (ife) -299.299987793 (T) 0.6999999881 (e) -10.1000003815 (c) 1.5 (hnol) 11.5 (o) -6.8000001907 (g) -1.2000000477 (i) 11.5 (e) -4.5999999046 (s\)) ] TJ
11.3791999817 0 TD
0.0105999997 Tc
[(in) -351.3999938965 (0.05) -351.3999938965 (M) -346.700012207 (s) -3.5999999046 (odium) -353.8999938965 (cacodylate) ] TJ
-11.3791999817 -1.2264000177 TD
0.3009000123 Tc
[(b) 288.700012207 (u) 292.299987793 (f) 291.1000061035 (f) 291.1000061035 (e) 285.1000061035 (r) 4.8000001907 (a) 290.8999938965 (n) 291.700012207 (d) 4.5999999046 (a) 285.1000061035 (l) 300.8999938965 (l) 282.8999938965 (o) 288.700012207 (w) 292.1000061035 (e) 290.8999938965 (dt) 293.1000061035 (os) 292.5 (e) 290.8999938965 (t) 281.6000061035 (,t) 293.200012207 (h) 286.5 (e) 290.8999938965 (ns) 292.5 (l) 289 (i) 300.8999938965 (c) 284.799987793 (e) 285.1000061035 (d) 4.5999999046 (i) 289 (n) 291.799987793 (t) 293.1000061035 (o1m) 289.299987793 (m) 92.5999984741 91.4000015259 (1) 2.5999999046 (m) 300.8999938965 (m) ] TJ
0 -1.220600009 TD
0.0108000003 Tc
[(bl) 10.8000001907 (o) -7.5 (c) 0.8000000119 (k) -9.8999996185 (s) -3.4000000954 (.) -326.6000061035 (B) 2.2000000477 (lock) -9.8999996185 (s) -327.299987793 (w) 2 (ere) -323.200012207 (p) -2 (laced) -326 (in) -328.1000061035 (gla) -10.8000001907 (s) 2.4000000954 (s) -327.299987793 (v) 0.200000003 (ials) -327.299987793 (with) -327.5 (50%) -327.700012207 (e) 0.8000000119 (tha-) ] TJ
0 -1.2264000177 TD
0.0104 Tc
[(nol) -435.3999938965 (a) 0.400000006 (nd) -430.5 (rocked) -436.299987793 (o) 10.3999996185 (n) -439.1000061035 (a) -445.1000061035 (s) -3.7999999523 (pe) -11.1999998093 (cimen) -432.6000061035 (r) -2.2000000477 (o) 10.3999996185 (t) -9.6000003815 (ato) 10.3999996185 (r) -442.5 (for) -430.299987793 (3) 1.2999999523 (0) -432.6000061035 (m) -1.2000000477 (inutes) ] TJ
T*
[(during) -308.8999938965 (ea) -5.4000000954 (ch) -304.799987793 (of) -306 (the) -312 (f) 0.6000000238 (ol) 10.3999996185 (l) -7.5999999046 (o) -1.7999999523 (wing) -308.8999938965 (wa) -11.1999998093 (shes) -9.6000003815 (:) -309.6000061035 (e) 0.400000006 (thano) 10.3999996185 (l) -314.5 (at) -309.700012207 (conc) -5.4000000954 (en-) ] TJ
0 -1.220600009 TD
0.0096000005 Tc
[(trati) 9.6000003815 (o) -8.6999998093 (ns) -415.299987793 (o) 9.6000003815 (f) -423.200012207 (50%,) -414.5 (70%) -415.700012207 (and) -408.1000061035 (9) -5.3000001907 (0%) -409.8999938965 (an) -5.3000001907 (d) -408.1000061035 (t) -3.9000000954 (wo) -413.3999938965 (times) -409.5 (a) -6.1999998093 (t) -408.8999938965 (100) -5.3000001907 (%,) ] TJ
0 -1.2264000177 TD
0 Tc
[(w) -8.8000001907 (i) -11.8999996185 (t) -13.5 (h) -274.700012207 (bo) -18.7000007629 (t) -13.5 (h) -274.700012207 (of) -282.3999938965 (t) -13.5 (h) -8.6000003815 (e) -276.1000061035 (l) 0 (a) -16.1000003815 (t) -13.5 (t) -13.5 (e) -10 (r) -272.8999938965 (i) 0 (n) -281.3999938965 (p) -12.8000001907 (r) -6.8000001907 (o) -12.1999998093 (p) -12.8000001907 (y) -10 (le) -21.8999996185 (n) -9.1000003815 (e) -276.1000061035 (ox) -20.7000007629 (id) -18.8999996185 (e) -10 (.) -273.700012207 (C) -11.3999996185 (e) -10 (l) -11.8999996185 (l) -11.8999996185 (s) -268.700012207 (w) -14.6000003815 (e) -10 (r) -12.6000003815 (e) -270.299987793 (l) -11.8999996185 (e) -10 (f) -9.8000001907 (t) ] TJ
T*
0.0107000005 Tc
[(overni) 10.6999998093 (g) -8.1000003815 (h) 2.0999999046 (t) -344.1000061035 (o) 10.6999998093 (n) -346.200012207 (a) -352.200012207 (spe) -10.8999996185 (c) 0.6999999881 (imen) -339.799987793 (ro) 10.6999998093 (t) -9.3000001907 (a) 0.6999999881 (to) 10.6999998093 (r) -349.700012207 (i) -1.2000000477 (n) -339.799987793 (1) 1.6000000238 (:1) -339.700012207 (propylene) -340.6000061035 (o) -1.5 (xide) ] TJ
0 -1.220600009 TD
0.0089999996 Tc
[(and) -582.299987793 (S) -1.7000000477 (purr) ] TJ
/F10 1 Tf
4.5469999313 0 TD
0 Tc
<92> Tj
/F7 1 Tf
0.144600004 0 TD
[(s) -586.9000244141 (s) -8.3999996185 (o) -12.1999998093 (l) -11.8999996185 (u) -8.6000003815 (t) -13.5 (io) -18.2999992371 (n) -587.700012207 (\() -13.5 (E) -10.6999998093 (l) 0 (e) -27.7000007629 (c) -15.8000001907 (t) -7.8000001907 (r) -12.6000003815 (on) -599.9000244141 (M) -10.1999998093 (i) 0 (c) -21.8999996185 (r) -6.8000001907 (o) -12.1999998093 (s) -8.3999996185 (c) -10 (o) -12.1999998093 (p) -12.8000001907 (y) -588.5 (S) -22.2000007629 (c) -10 (ie) -21.8999996185 (n) -9.1000003815 (c) -10 (e) -10 (s) -8.3999996185 (\)) -13.5 (.) ] TJ
-4.6916999817 -1.2264000177 TD
0.0108000003 Tc
[(T) 10.8000001907 (h) -2.9000000954 (e) -282.700012207 (n) 1.6000000238 (ext) -286.200012207 (d) 3.7999999523 (ay) -5 (,) -280.299987793 (s) -3.4000000954 (amples) -286.799987793 (were) -282.700012207 (placed) -285.5 (in) -281.799987793 (fresh) -287 (S) 0.1000000015 (purr) ] TJ
/F10 1 Tf
20.9244003296 0 TD
0 Tc
<92> Tj
/F7 1 Tf
0.144600004 0 TD
0.2976000011 Tc
[(ss) 289.200012207 (o) 285.3999938965 (l) 297.6000061035 (u) 277.1000061035 (-) ] TJ
-21.0690994263 -1.2264000177 TD
0.0104 Tc
[(ti) 10.3999996185 (o) -7.9000000954 (n) -473.1000061035 (for) -476.6000061035 (6) -473.1000061035 (hours) -478.1000061035 (a) 0.400000006 (nd) -476.799987793 (placed) -476.799987793 (in) -473.1000061035 (flat) -477.5 (emb) 10.3999996185 (e) -11.8000001907 (ddi) 10.3999996185 (n) -10.6000003815 (g) -470.8999938965 (m) -1.2000000477 (olds) ] TJ
0 -1.220600009 TD
0.0098999999 Tc
[(with) -449.8999938965 (fre) -5.9000000954 (s) 1.5 (h) -449.8999938965 (S) -0.8000000119 (purr) ] TJ
/F10 1 Tf
7.2602000237 0 TD
0 Tc
<92> Tj
/F7 1 Tf
0.144600004 0 TD
0.0102000004 Tc
[(s) -449.3999938965 (s) 1.7999999523 (olution) -450.200012207 (a) 0.200000003 (t) -448.799987793 (6) 1.1000000238 (0) -4.6999998093 1.8999999762 (C) -446.700012207 (f) -5.4000000954 (o) 10.1999998093 (r) -460.1000061035 (48) -450.1000061035 (hours.) -448.6000061035 (Se) -11.3999996185 (c) 10.1999998093 (-) ] TJ
-7.4047999382 -1.2264000177 TD
0.0107000005 Tc
[(ti) 10.6999998093 (o) -7.5999999046 (n) 1.6000000238 (s) -477.799987793 (w) -3.9000000954 (ere) -485.299987793 (c) -5.0999999046 (ut) -477.200012207 (to) -481.700012207 (90-nm) -481.1000061035 (thi) 10.6999998093 (c) -5.4000000954 (kness) -20.7999992371 (,) -482.8999938965 (placed) -482.299987793 (on) -478.6000061035 (copper) ] TJ
T*
0.0104 Tc
[(200-) 10.3999996185 (m) -7.5 (esh) -287.3999938965 (g) -2.2999999523 (rids) -293 (and) -291.6000061035 (c) 0.400000006 (ontra) -11.1999998093 (s) 2 (ted) -291.6000061035 (o) 10.3999996185 (n) -300.200012207 (d) 3.4000000954 (roplet) -8.8999996185 (s) -293 (o) 10.3999996185 (f) -300.8999938965 (2) 1.2999999523 (%) -287.6000061035 (u) -4 (ranyl) ] TJ
0 -1.220600009 TD
0.0212999992 Tc
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[(from) -794.299987793 (the) -792.799987793 (G) 2.5 (ST) -701 (and) -795.5 (G) 2.5 (ST) 51 (-MKS) 4.9000000954 (3) -797.5999755859 (p) 2.7999999523 (rote) -6 (ins.) -796.0999755859 (Protein-) ] TJ
T*
[(bound) -864.700012207 (b) -2.2000000477 (eads) -866.0999755859 (w) -4.5 (ere) -867.799987793 (s) -4.0999999046 (tored) -870.5 (a) 0 (t) -871.299987793 (4) 0.8999999762 -869.200012207 (in) -866.9000244141 (phosphate-) ] TJ
0 -1.220600009 TD
0.0147000002 Tc
[(buffered) -403 (s) 0.5 (aline) -406.1000061035 (f) -0.8999999762 (or) -402.799987793 (up) -403 (to) -402.5 (2) -399.299987793 (w) 0.1000000015 (eek) -11.6999998093 (s.) ] TJ
0.8156999946 -1.2264000177 TD
0.0103000002 Tc
[(Sto) 10.3000001907 (c) -11.8999996185 (k) -403.700012207 (51s) ] TJ
/F8 1 Tf
4.5816998482 0 TD
0.0110999998 Tc
[(P.) -407.299987793 (tetr) 11.1000003815 (aure) 11.1000003815 (l) -9.1999998093 (i) 2.7999999523 (a) ] TJ
/F7 1 Tf
6.1206002235 0 TD
0.0096000005 Tc
[(cell) 9.6000003815 (s) -415.6000061035 (we) -6.1999998093 (re) -416.8999938965 (c) -6.1999998093 (u) 1 (ltured) -408.1000061035 (and) -408.1000061035 (h) -4.8000001907 (ar) 9.6000003815 (-) ] TJ
-11.517999649 -1.2264000177 TD
0.0107000005 Tc
[(vested) -482.200012207 (a) -10.8999996185 (s) -489.3999938965 (described) -482.200012207 (p) -2.0999999046 (re) -10.8999996185 (viousl) 10.6999998093 (y) -491.3999938965 ([) -2.7999999523 (34]) -483 (for) -487.799987793 (w) 1.8999999762 (hole-cell) -481.3999938965 (e) 0.6999999881 (x-) ] TJ
0 -1.220600009 TD
0.0102000004 Tc
[(tract) -1090.9000244141 (\(WCE\).) -1090.8000488281 (Glutathi) 10.1999998093 (o) -8.1000003815 (n) 1.1000000238 (e) -1093.1999511719 (s) 1.7999999523 (e) -5.5999999046 (p) 3.2000000477 (ha) -5.5999999046 (rose) -1093.1999511719 (beads) -1091.5999755859 (\() -3.2999999523 (GE) ] TJ
0 -1.2264000177 TD
[(Healthcare) -589.799987793 (L) -0.400000006 (i) 10.3000001907 (f) -5.5999999046 (e) -589.799987793 (S) -11.8999996185 (ciences\)) -587.5 (w) 1.5 (ere) -589.799987793 (p) 3.2999999523 (repa) -5.5 (red) -586.799987793 (b) -1.8999999762 (y) -589.799987793 (w) 1.5 (a) -11.3000001907 (s) -3.9000000954 (hing) ] TJ
T*
0.0104 Tc
[(thre) -5.4000000954 (e) -884.700012207 (t) 2.7000000477 (imes) -883.0999755859 (in) -883.9000244141 (L) -35 (A) 1.1000000238 (P200) -883.799987793 (bu) -4 (ffer) -881.5 (\() -3.0999999046 (50) -883.799987793 (mM) -884.9000244141 (HEPE) -11.8999996185 (S) -11.8000001907 (,) ] TJ
0 -1.220600009 TD
0.5418999791 Tc
[(2) 532.799987793 (0) 532.799987793 (0) 0.6000000238 (m) 530.299987793 (M) -0.5 (K) 541.9000244141 (C) 531.200012207 (l) 530 (,) 2.0999999046 (1m) 530.299987793 (ME) 531.200012207 (G) 528.799987793 (T) 594.700012207 (A) 497.799987793 (,) 2.0999999046 (1m) 530.299987793 (MM) 541.9000244141 (g) 530.5999755859 (C) 530.5 (l) ] TJ
7.3499999046 0 0 6.5324001312 245.7637023926 575.3195800781 Tm
0 Tc
(2) Tj
9.7999000549 0 0 9.7999000549 249.5054016113 576.9636230469 Tm
0.5443999767 Tc
[(,p) 537.4000244141 (H7) 535.299987793 (.) 531 (4) 535.299987793 (\)) ] TJ
-19.6749000549 -1.2264000177 TD
0.0100999996 Tc
[(buffe) -5.6999998093 (r) -482.700012207 (w) 1.2999999523 (ith) -484.3999938965 (1) 1 (%) -484.6000061035 (T) -0.6999999881 (riton) -485 (X) 31.7999992371 (-100.) -483.5 (Wa) -11.5 (shed) -488.6000061035 (b) 10.1000003815 (e) -12.1000003815 (ads) -484.200012207 (\() -3.4000000954 (200) ] TJ
/F11 1 Tf
22.7178001404 0 TD
0 Tc
() Tj
/F7 1 Tf
0.5496000051 0 TD
0.0119000003 Tc
(l\)) Tj
-23.2674007416 -1.2264000177 TD
0.0103000002 Tc
[(we) -5.5 (re) -491.3999938965 (added) -488.3999938965 (t) -3.2000000477 (o) -487.8999938965 (2) 1.2000000477 (0) -490.5 (m) -1.2999999523 (l) -487.5 (o) 10.3000001907 (f) -497.700012207 (W) 2.0999999046 (CE.) -489 (T) 10.3000001907 (hi) 10.3000001907 (s) -495.8999938965 (p) -2.5 (re) -11.3000001907 (cleared) -488.3999938965 (WC) 10.3000001907 (E) ] TJ
0 -1.220600009 TD
0.0104999999 Tc
[(wa) -11.1000003815 (s) -541.700012207 (t) -3 (hen) -542.4000244141 (s) 2.0999999046 (pl) 10.5 (i) -7.5 (t) -541 (in) -536.700012207 (ha) -5.3000001907 (l) 10.5 (f) -549.200012207 (and) -540.299987793 (i) -1.3999999762 (ncubated) -540.299987793 (with) -536.0999755859 (2) -4.4000000954 (0) 1.3999999762 (0) ] TJ
/F11 1 Tf
21.6765003204 0 TD
0 Tc
() Tj
/F7 1 Tf
0.5554000139 0 TD
0.5498999953 Tc
[(lo) 549.9000244141 (f) ] TJ
-22.2318992615 -1.2264000177 TD
0.0103000002 Tc
[(gl) 10.3000001907 (u) -10.1999998093 (t) 2.5999999046 (athione) -607.0999755859 (s) -3.9000000954 (epharose) -612.9000244141 (beads) -611.299987793 (a) 0.3000000119 (ttached) -609.9000244141 (to) -609.299987793 (either) -609.700012207 (GST) ] TJ
T*
0.0108000003 Tc
[(or) -412.5 (GST) 52 (-) 10.8000001907 (M) -5.5999999046 (K) 0 (S3.) -413.299987793 (B) 2.2000000477 (eads) -414.1000061035 (i) -1.1000000238 (n) -409.1000061035 (t) -2.7000000477 (he) -415.700012207 (supernatant) -413.5 (w) -3.7999999523 (ere) -415.700012207 (a) 0.8000000119 (llo) 10.8000001907 (w) -10.1999998093 (e) 0.8000000119 (d) ] TJ
0 -1.220600009 TD
0.0116999997 Tc
[(to) -561.700012207 (r) 4.9000000954 (o) -0.5 (ck) -564.299987793 (on) -564.4000244141 (i) 11.6999998093 (c) -10.1999998093 (e) -559.5 (a) -4.0999999046 (t) -563 (4) 2.5999999046 3.4000000954 (C) -566.700012207 (fo) 11.6999998093 (r) -574.299987793 (1) -558.5 (hour) 4.9000000954 (.) -568.5999755859 (C) 11.6999998093 (ontr) 4.9000000954 (ol) -561.299987793 (and) -562.200012207 (t) -1.7999999523 (es) 3.2999999523 (t) ] TJ
0 -1.2264000177 TD
0.0104999999 Tc
[(beads) -755.700012207 (w) -4.0999999046 (ere) -757.4000244141 (r) -2.0999999046 (e) -11.1000003815 (c) 0.5 (overed) -765.9000244141 (and) -760.0999755859 (w) 1.7000000477 (a) -11.1000003815 (s) -3.7000000477 (hed) -760.0999755859 (t) -3 (hree) -757.4000244141 (times) -761.5 (i) 10.5 (n) ] TJ
T*
0.0103000002 Tc
[(L) -29.2999992371 (A) -4.8000001907 (P200) -542.5999755859 (b) 10.3000001907 (u) -10.5 (ffer) -540.299987793 (w) 1.5 (ith) -536.299987793 (1) -4.5999999046 (%) -536.5 (T) -0.5 (riton) -542.5999755859 (X) 32 (-100.) -541.0999755859 (Sampl) 10.3000001907 (e) -5.8000001907 (s) -541.9000244141 (w) -4.3000001907 (ere) ] TJ
0 -1.220600009 TD
0.0104999999 Tc
[(run) -681.299987793 (o) -1.7000000477 (n) -681.299987793 (a) -682.0999755859 (7%) -680.9000244141 (to) -678.5999755859 (14%) -680.9000244141 (g) -2.2000000477 (radient) -679.9000244141 (a) 0.5 (c) -5.3000001907 (r) 3.7000000477 (ylamide) -682.0999755859 (g) -2.2000000477 (el) -684 (and) ] TJ
0 -1.2264000177 TD
0.0100999996 Tc
[(silver) 10.1000003815 (-) 10.1000003815 (s) 0.200000003 (tained,) -495 (t) -3.4000000954 (hen) -496.6000061035 (g) -2.5999999046 (el) -499.299987793 (sli) 10.1000003815 (c) -11.8000001907 (es) -495.799987793 (we) -5.6999998093 (re) -497.3999938965 (trypsin-digested) -494.3999938965 (a) -11.5 (s) ] TJ
T*
[(descri) 10.1000003815 (b) -8.1999998093 (e) 0.1000000015 (d) -401.8999938965 (p) -2.7000000477 (re) -11.5 (viously) -399.1000061035 ([) -3.4000000954 (34]) -3.4000000954 (.) ] TJ
0.8156999946 -1.220600009 TD
0 Tc
[(S) -10.6999998093 (a) -10 (m) -11.6000003815 (p) -12.8000001907 (le) -21.8999996185 (s) -633.200012207 (w) -8.8000001907 (e) -15.8000001907 (r) -6.8000001907 (e) -634.799987793 (a) -10 (n) -14.8999996185 (a) -10 (ly) -21.8999996185 (z) -8.3999996185 (e) -10 (d) -637.5999755859 (b) 0 (y) -647 (l) 0 (i) -18 (q) -12.8000001907 (u) -8.6000003815 (i) -11.8999996185 (d) -631.799987793 (c) -10 (h) -14.3999996185 (r) -6.8000001907 (o) -12.1999998093 (m) -11.6000003815 (a) -10 (t) -13.5 (o) -12.1999998093 (g) -6.9000000954 (r) -12.6000003815 (a) -10 (p) -7 (h) -14.3999996185 (y) -10 (-) ] TJ
-0.8156999946 -1.2264000177 TD
0.0119000003 Tc
[(tand) 4.9000000954 (em) -572.4000244141 (m) 11.8999996185 (a) -15.5 (ss) -569.200012207 (s) 3.5 (p) -0.8999999762 (e) -9.6999998093 (c) 1.8999999762 (tr) 5.0999999046 (omet) 4.1999998093 (ry) -570.799987793 (\(LC-) 11.8999996185 (MS/MS\)) -574.299987793 (on) -570 (a) -570.799987793 (l) 0 (i) 11.8999996185 (n) -9.1000003815 (ear) ] TJ
T*
0.0100999996 Tc
[(io) 10.1000003815 (n) -439.3999938965 (t) -3.4000000954 (rap) -430.799987793 (L) 80.4000015259 (TQ) -435.299987793 (XL) -434.5 (Li) 10.1000003815 (n) -10.8999996185 (ear) -430.6000061035 (Ion) -432.8999938965 (T) -0.8000000119 (rap) -436.6000061035 (M) -0.1000000015 (a) -11.5 (s) 1.7000000477 (s) -432.200012207 (S) -0.6000000238 (pe) -11.5 (ctro) 10.1000003815 (m) -8 (e) 0.1000000015 (ter) ] TJ
0 -1.220600009 TD
0.0110999998 Tc
[(\() -8.1999998093 (T) 11.1000003815 (herm) 11.1000003815 (o) -539.200012207 (F) 11.1000003815 (i) -7.1999998093 (s) -3.0999999046 (her) -527.9000244141 (S) -11.1000003815 (cientific) -10.5 (,) -528.700012207 (A) -9.8000001907 (s) 2.7000000477 (he) -10.5 (v) 11.1000003815 (i) -5.5999999046 (lle,) -528.700012207 (N) -9.8999996185 (C) -17.7000007629 (,) -528.700012207 (USA\).) -528.700012207 (H) 0.1000000015 (al) 11.1000003815 (f) ] TJ
0 -1.2264000177 TD
0.0107000005 Tc
[(the) -433.200012207 (m) -0.8999999762 (aterial) -435.1000061035 (w) 1.8999999762 (a) -10.8999996185 (s) -431.6000061035 (loaded) -430.200012207 (onto) -429.6000061035 (a) -439 (100-) ] TJ
/F11 1 Tf
16.1112995148 0 TD
0 Tc
() Tj
/F7 1 Tf
0.5496000051 0 TD
0.2089000046 Tc
[<6DD731> 199.8000030518 (2) 194 (0) -234.1000061035 (m) 197.3000030518 (m) -230.8000030518 (c) 193.1000061035 (a) 198.8999938965 (-) ] TJ
-16.660900116 -1.2264000177 TD
0.0108000003 Tc
[(pi) 10.8000001907 (l) -7.1999998093 (l) -1.1000000238 (ary) -525.700012207 (c) 0.8000000119 (ol) 10.8000001907 (u) -9.6999998093 (m) -0.8000000119 (n) -519 (p) -2 (acked) -522.5999755859 (wi) 10.8000001907 (t) -8.8000001907 (h) -524.200012207 (M) -16.7000007629 (A) -4.3000001907 (GIC) -527.0999755859 (C) 10.8000001907 (1) -9.6999998093 (8) -518.9000244141 (\(5-) ] TJ
/F11 1 Tf
20.2129001617 0 TD
0 Tc
() Tj
/F7 1 Tf
0.5554000139 0 TD
0.5322999954 Tc
[(mp) 519.5 (a) 522.299987793 (r) 532.299987793 (-) ] TJ
-20.7682991028 -1.220600009 TD
0.0109000001 Tc
[(ti) 10.8999996185 (c) -5.1999998093 (l) -1 (e) -687.5 (s) 2.5 (ize,) -690.9000244141 (20-nm) -683.299987793 (pore) -687.5 (si) 10.8999996185 (z) -9.3999996185 (e) 0.8999999762 (;) -685.0999755859 (M) 0.6999999881 (ichrom) -683.299987793 (Bi) 10.8999996185 (o) -7.4000000954 (r) -1.7000000477 (esources) -20.6000003815 (,) ] TJ
0 -1.2264000177 TD
0 Tc
[(A) -9.3000001907 (u) -14.3999996185 (bu) -20.7999992371 (r) -6.8000001907 (n) -14.8999996185 (,) -429.8999938965 (C) -34.5999984741 (A) -38.2999992371 (,) -435.700012207 (U) -11.5 (S) -10.6999998093 (A) -9.3000001907 (\)) -435.799987793 (a) -10 (t) -430.1000061035 (a) -438.1000061035 (f) -9.8000001907 (l) -11.8999996185 (o) 0 (w) -443.299987793 (r) -6.8000001907 (a) -15.8000001907 (t) -7.6999998093 (e) -432.299987793 (o) -12.1999998093 (f) -432.1000061035 (5) -14.8999996185 (0) -9.1000003815 (0) -431.3999938965 (n) -9.1000003815 (l) -11.8999996185 (/) -12 (m) -11.6000003815 (in) -15.3000001907 (.) -435.700012207 (P) -10.6999998093 (e) -10 (p) -12.8000001907 (-) ] TJ
T*
0.0102000004 Tc
[(ti) 10.1999998093 (d) -8.6999998093 (e) 0.200000003 (s) -692.4000244141 (w) -4.4000000954 (ere) -699.799987793 (s) 1.7999999523 (epara) -5.5999999046 (t) 2.5 (ed) -696.799987793 (by) -694 (a) -694 (g) -2.5 (radient) -697.5 (o) 10.1999998093 (f) -706.0999755859 (5) 1.1000000238 (%) -692.799987793 (t) -3.2999999523 (o) -696.200012207 (35%) ] TJ
0 -1.220600009 TD
0.0114000002 Tc
(CH) Tj
7.3499999046 0 0 6.5324001312 71.0929031372 323.3196105957 Tm
0 Tc
(3) Tj
9.7999000549 0 0 9.7999000549 74.834602356 324.9637145996 Tm
0.0105999997 Tc
[(CN) -4.5999999046 (/) 10.6000003815 (0) -4.6999998093 (.1%) -744.4000244141 (f) -5 (o) 10.6000003815 (r) -8.3999996185 (mi) 10.6000003815 (c) -751.799987793 (a) -5.1999998093 (ci) 10.6000003815 (d) -754.5999755859 (f) 0.8000000119 (or) -742.5 (30) -744.799987793 (minu) -3.7999999523 (tes) -20.8999996185 (,) -749.0999755859 (40%) -744.4000244141 (to) ] TJ
-1.8511999846 -1.2264000177 TD
0.0091000004 Tc
[(100) -5.8000001907 (%) -740.200012207 (C) 9.1000003815 (H) ] TJ
7.3499999046 0 0 6.5324001312 100.2331008911 311.3006896973 Tm
0 Tc
(3) Tj
9.7999000549 0 0 9.7999000549 104.03150177 312.9447937012 Tm
[(C) -11.3999996185 (N) -9.3999996185 (/) -12 (0) -9.1000003815 (.) -7.5999999046 (1) -14.8999996185 (%) -749.299987793 (f) -9.8000001907 (or) -19 (m) -11.6000003815 (i) -11.8999996185 (c) -744.700012207 (a) -10 (c) -15.8000001907 (i) 0 (d) -753.5999755859 (f) -15.6000003815 (or) -753.700012207 (1) -749.5999755859 (m) -11.6000003815 (i) -11.8999996185 (n) -9.1000003815 (u) -8.6000003815 (t) -13.5 (e) -744.700012207 (a) -15.8000001907 (n) -9.1999998093 (d) ] TJ
-4.8305001259 -1.2264000177 TD
0.0091000004 Tc
[(100) -5.8000001907 (%) -398.799987793 (C) -2.2999999523 (H) ] TJ
7.3499999046 0 0 6.5324001312 96.9449005127 299.3385009766 Tm
0 Tc
(3) Tj
9.7999000549 0 0 9.7999000549 100.7433013916 300.9259033203 Tm
[(CN) -420 (f) -9.8000001907 (o) -12.1999998093 (r) -406 (1) -14.8999996185 (0) -408.200012207 (m) -11.6000003815 (in) -21 (u) -8.6000003815 (t) -7.6999998093 (e) -15.8000001907 (s) -8.3999996185 (.) ] TJ
-3.6793000698 -1.220600009 TD
[(Prod) -7.9000000954 (uct) -1050.3000488281 (ion) -1051.4000244141 (spe) -13.8000001907 (ctra) -1052.8000488281 (wer) -8.3000001907 (e) -1045.5 (searc) -10.6000003815 (hed) -1049.5999755859 (using) -1057.4000244141 (the) ] TJ
-0.8156999946 -1.2264000177 TD
[(SEQUE) -20.3999996185 (ST) -484.299987793 (searc) -10.6000003815 (h) -569.700012207 (engine) -577.9000244141 (on) -571 (Prot) -8.6000003815 (eome) -576.0999755859 (Discove) -11 (rer) -573.200012207 (1.4) ] TJ
T*
[(\() -13.5 (T) 12.3000001907 (her) -8.1000003815 (mo) -370.8999938965 (Fisher) -376.1000061035 (S) -10.6999998093 (cientific\)) -372.1000061035 (against) -376.6000061035 (a) -368.700012207 (curated) ] TJ
/F8 1 Tf
19.0617008209 0 TD
[(P.) -371.200012207 (tetraure-) ] TJ
-19.0617008209 -1.220600009 TD
(lia) Tj
/F7 1 Tf
1.4867999554 0 TD
[(databa) -16.6000003815 (se) -394.3999938965 (with) -389.8999938965 (seq) -8.1000003815 (uences) -397.5 (in) -385.5 (forw) -8.6999998093 (ard) -394.1000061035 (and) -390.6000061035 (re) -11 (verse) -392.8999938965 (or) -7.5 (i-) ] TJ
-1.4867999554 -1.2264000177 TD
[(entat) -10 (ions.) -315.3999938965 (The) -312.8999938965 (13) -313.200012207 (raw) -320.6000061035 (files) -318.1000061035 (from) -318.200012207 (control) -324.6000061035 (sampl) -8.3999996185 (es) -313.3999938965 (and) -315.3999938965 (the) ] TJ
T*
[(13) -301.6000061035 (raw) -303.299987793 (file) -8.8999996185 (s) -297.6000061035 (from) -306.6000061035 (test) -317.3999938965 (samp) -8.1000003815 (les) -302.200012207 (were) -307.5 (searched) -308.1000061035 (a) -15.8000001907 (s) -297.6000061035 (one) -314.8999938965 (con) -8.3000001907 (-) ] TJ
0 -1.220600009 TD
[(tiguou) -9.6999998093 (s) -390.200012207 (inpu) -7.6999998093 (t) -389.6000061035 (file) -8.8999996185 (,) -389.3999938965 (and) -396.3999938965 (a) -403.3999938965 (sing) -7.5 (le) -392.200012207 (result) -400.6000061035 (file) -396.5 (wa) -13 (s) -390.200012207 (gener) -8.1999998093 (ated) ] TJ
0 -1.2264000177 TD
[(for) -295 (each.) -300.799987793 (T) 12.3000001907 (h) 0 (e) -296.299987793 (databa) -22.2999992371 (se) -290.299987793 (wa) -13 (s) -291.799987793 (inde) -9.1999998093 (xed) -291.700012207 (to) -297.700012207 (allow) -297.799987793 (for) -295 (full) -296.700012207 (tryp-) ] TJ
0 -1.220600009 TD
[(sin) -295.5 (enzy) -8.6999998093 (matic) -300.1000061035 (activity,) -307.3999938965 (two) -294.8999938965 (misse) -9.8000001907 (d) -296.299987793 (cleavages) -290.3999938965 (an) -7.5999999046 (d) -290.5 (pept) -8.6999998093 (ides) ] TJ
0 -1.2264000177 TD
[(betw) -9.8999996185 (een) -596.0999755859 (the) -599.0999755859 (mole) -16.7999992371 (cular) -602.700012207 (w) -20.2999992371 (e) -21.6000003815 (i) -23.5 (g) -18.5 (h) -20.1000003815 (t) -30.8999996185 (s) -586.9000244141 (o) -18 (f) -588.299987793 (3) -20.7000007629 (5) -20.7000007629 (0) -581.799987793 (t) -25.1000003815 (o) -584.9000244141 (5) -20.7000007629 (,) -19.2000007629 (0) -20.7000007629 (0) -20.7000007629 (0) -581.799987793 (D) -23.1000003815 (a) -21.6000003815 (.) ] TJ
T*
0.0208999999 Tc
[(Search) -404.200012207 (parameters) -404 (set) -403.3999938965 (t) -4.1999998093 (he) -405.6000061035 (ma) -12.3000001907 (ss) -404 (tolera) 5.0999999046 (nce) -405.6000061035 (a) -0.6999999881 (t) -403.3999938965 (2) -404.700012207 (Da) -399.8999938965 (for) ] TJ
0 -1.220600009 TD
0.0210999995 Tc
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0 -1.2264000177 TD
0.0208000001 Tc
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T*
-0.0200999994 Tc
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0 -1.220600009 TD
-0.0181000009 Tc
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0 -1.2264000177 TD
0.0103000002 Tc
[(the) -306.299987793 (f) 0.5 (alse) -5.5 (-) 10.3000001907 (p) -8.6999998093 (ositive) -306.299987793 (r) -2.2999999523 (ates) -310.5 (to) -308.5 (less) -310.5 (than) -305.5 (1%) -310.8999938965 (in) -305.5 (bo) 10.3000001907 (t) -9.6999998093 (h) -304.8999938965 (data) -317.8999938965 (set) -9 (s) -3.9000000954 (.) ] TJ
T*
0.0093999999 Tc
[(T) 9.3999996185 (h) -4.1999998093 (e) -469.200012207 (x) 9.3999996185 (corr) -506.5 (values) -473.3999938965 (w) -5.1999998093 (e) -0.6000000238 (re) -475 (a) -12.1999998093 (s) -473.3999938965 (fol) 9.3999996185 (l) -8.6000003815 (ows) -10.6000003815 (:) -478.3999938965 (\(+1\):) -472.6000061035 (1) -5.5 (.8,) -472.6000061035 (\() -4.0999999046 (+2) -5.5 (\):) -472.6000061035 (2.7,) ] TJ
0 -1.220600009 TD
0 Tc
[(\() -13.5 (+) -7.0999999046 (3) -9.1000003815 (\)) -13.5 (:) -331.6000061035 (3) -9.1000003815 (.) -7.5999999046 (3) -333 (a) -10 (n) -14.8999996185 (d) -331 (\() -7.6999998093 (+) -12.8999996185 (4) -9.1000003815 (\)) -7.6999998093 (:) -337.3999938965 (3) -9.1000003815 (.) -7.5999999046 (5) -9.1000003815 (.) -331.6000061035 (O) -11.5 (t) -13.5 (h) -8.6000003815 (e) -10 (r) -330.799987793 (f) 0 (i) 13 (l) 11.1999998093 (te) 11.1999998093 (rs) -304.3999938965 (ap) 17.7000007629 (pl) 15.8000001907 (i) 11.1999998093 (e) 0 (d) -306.299987793 (w) 0 (e) 10.1000003815 (r) 0 (e) -300.299987793 (a) -316.6000061035 (mi) 17 (ni) 13.6999998093 (-) ] TJ
0 -1.2264000177 TD
[(mu) 14.5 (m) -300.8999938965 (p) 0 (e) 11.8999996185 (p) 0 (t) 19.8999996185 (i) 0 (d) 15.8000001907 (e) -316.6000061035 (cu) 16.1000003815 (to) 14.6999998093 (ff) -297.299987793 (o) 10.8999996185 (f) -304.8999938965 (2) -304.1000061035 (a) 0 (s) -301.8999938965 (w) 0 (e) 10.1000003815 (l) 11.1999998093 (l) -301.1000061035 (a) -21.6000003815 (s) -320.799987793 (D) -11.5 (e) -10 (l) -11.8999996185 (t) -13.5 (a) -10 (C) -11.3999996185 (N) -321.799987793 (>) -8.6000003815 (0) -9.1000003815 (.) -13.3999996185 (1) -9.1000003815 (.) -320 (U) -11.5 (l) -11.8999996185 (t) -7.6999998093 (i) -11.8999996185 (m) -11.6000003815 (-) ] TJ
T*
0.0104 Tc
[(atel) 10.3999996185 (y) -11.5 (,) -523.700012207 (the) -531.799987793 (c) -5.4000000954 (o) 10.3999996185 (n) -11 (fi) 10.3999996185 (d) -8.5 (e) 0.400000006 (nce) -526.0999755859 (p) -2.4000000954 (arameters) -524.4000244141 (r) -2.2000000477 (esulted) -523 (i) -1.5 (n) -525.200012207 (0) 1.2999999523 (%) -524.799987793 (f) 0.6000000238 (alse) ] TJ
25.3094997406 64.8964004517 TD
0.0109000001 Tc
[(di) 10.8999996185 (s) -9.3999996185 (c) 0.8999999762 (ov) 10.8999996185 (e) -9.6999998093 (r) 4.0999999046 (y) -363.6000061035 (r) 4.0999999046 (ate) -363.6000061035 (a) 0.8999999762 (t) -361.299987793 (t) -2.5999999046 (he) -363.6000061035 (p) 3.9000000954 (r) -1.7000000477 (otein) -362.700012207 (a) 0.8999999762 (nd) -360.6000061035 (pep) 3.9000000954 (t) -2.5999999046 (id) 3.9000000954 (e) -363.6000061035 (l) -1 (e) -10.6999998093 (v) 0.3000000119 (el) -359.700012207 (for) -360.3999938965 (both) ] TJ
0 -1.220600009 TD
0.0104 Tc
[(the) -283.1000061035 (c) 0.400000006 (o) 10.3999996185 (n) -11 (tro) 10.3999996185 (l) -279.799987793 (and) -268.5 (t) -3.0999999046 (est) -275 (r) 3.5999999046 (esult) -8.8999996185 (s) 2 (.) ] TJ
/F1 1 Tf
10.3000001907 0 0 10.3000001907 304.7243041992 660.92578125 Tm
0 Tc
(Results) Tj
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 648.9636230469 Tm
[(Sequence) -309.200012207 (analys) -8 (is) ] TJ
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 636.9448242188 Tm
-0.0175000001 Tc
[(Th) -17.5 (e) -470 (s) -17.5 (eq) -17.5 (ue) -17.5 (nc) -17.5 (e) -471.3999938965 (f) -17.5 (or) ] TJ
/F8 1 Tf
7.9197001457 0 TD
0 Tc
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.9965999126 0 TD
-0.0111999996 Tc
(in) Tj
/F8 1 Tf
1.2611000538 0 TD
-0.0182000007 Tc
[(Pa) -18.2000007629 (r) 8.5 (a) -18.2000007629 (me) -7.0999999046 (c) -18.2000007629 (i) -2.2999999523 (u) -18.2000007629 (m) ] TJ
/F7 1 Tf
5.6403999329 0 TD
0 Tc
[(\(G) 13.8999996185 (S) 12.5 (P) 58.7000007629 (A) 71.5999984741 (T) 0 (G) 16.6000003815 (0) 0 (0) 16.5 (0) 14.1000003815 (1) ] TJ
-17.817899704 -1.2264000177 TD
-0.0197999999 Tc
[(593) -5.6999998093 (9001) -5.6999998093 (,) -380.299987793 (4) 0 (e) ] TJ
/F12 1 Tf
7.3499999046 0 0 6.5324001312 352.3464050293 629.2911987305 Tm
0 Tc
() Tj
/F7 1 Tf
0.5630999804 0 TD
-0.0218000002 Tc
(57) Tj
9.7999000549 0 0 9.7999000549 363.458190918 624.92578125 Tm
-0.0176999997 Tc
[(,) -384 (23%) -379.3999938965 (identit) 3.5 (y) 1.2000000477 (\)) -384.1000061035 (w) 2.4000000954 (a) -17.7000007629 (s) -377.3999938965 (found) -383.3999938965 (u) 2.5999999046 (si) 5.0999999046 (ng) -377.5 (the) -380.6000061035 (h) -3.0999999046 (uman) ] TJ
-5.9932999611 -1.220600009 TD
-0.0189999994 Tc
[(se) -5.9000000954 (quence) -266.200012207 (for) ] TJ
/F8 1 Tf
5.3049001694 0 TD
-0.0186999999 Tc
[(TME) -35.2000007629 (M) 0.6000000238 (67) ] TJ
/F7 1 Tf
4.2172999382 0 TD
[(\(Q5HY) 39.4000015259 (A) 0.8999999762 (8) -4.5999999046 (\)) -257.8999938965 (an) -4.6999998093 (d) -257.1000061035 (t) -3.2999999523 (he) -265.8999938965 (annotated) ] TJ
/F8 1 Tf
12.0907001495 0 TD
-0.0253999997 Tc
[(Para) -9.3000001907 (-) ] TJ
-21.6128997803 -1.2264000177 TD
-0.0188999996 Tc
[(meciu) -4.9000000954 (m) ] TJ
/F7 1 Tf
3.5924999714 0 TD
-0.0232999995 Tc
[(genome) -426.700012207 (\(P) -5.0999999046 (arame) -10.1999998093 (c) 1.3999999762 (iumDB,) -418.5 (http://parame) -10.1999998093 (c) -4.4000000954 (ium.cgm.) ] TJ
-3.5924999714 -1.2264000177 TD
-0.0234999992 Tc
[(cnrs) -23.5 (-) 8.1999998093 (g) 4.3000001907 (if.fr/\).) ] TJ
/F8 1 Tf
4.9173002243 0 TD
-0.0274 Tc
[(Para) -5.5 (me) -4.8000001907 (c) -9 (i) -0.8999999762 (um) -303 (MK) -7.8000001907 (S3) ] TJ
/F7 1 Tf
8.081700325 0 TD
0 Tc
(\() Tj
/F8 1 Tf
0.3007999957 0 TD
-0.0244999994 Tc
[(TME) -35.2000007629 (M) -5.1999998093 (67) ] TJ
/F7 1 Tf
3.9223001003 0 TD
0.2734000087 Tc
[(\)c) 298.1000061035 (o) 295.8999938965 (d) 295.299987793 (e) 298.1000061035 (s) -1.1000000238 (f) 298.299987793 (o) 295.8999938965 (r2) 299 (,) 300.5 (9) 293.200012207 (0) 299 (6) ] TJ
-17.2220001221 -1.220600009 TD
0.0109000001 Tc
[(nucl) 10.8999996185 (e) -11 (i) 10.8999996185 (c) -323.3999938965 (a) -4.9000000954 (ci) 10.8999996185 (d) -8 (s) -315.700012207 (and) -314.299987793 (9) 1.7999999523 (51) -316.3999938965 (amino) -319.5 (acids.) -320.700012207 (T) 10.8999996185 (he) -317.299987793 (RNAi) -319.200012207 (construct) ] TJ
0 -1.2264000177 TD
0.0199999996 Tc
[(design) -498.200012207 (for) ] TJ
/F8 1 Tf
5.0156002045 0 TD
0.0088 Tc
[(Pa) -15.6000003815 (ra) -15.6000003815 (m) -12.1999998093 (e) -9.1000003815 (c) -13.3000001907 (i) -11 (u) -11.8999996185 (m) -509.799987793 (M) -12.3999996185 (K) -12 (S) -11.3000001907 (3) ] TJ
/F7 1 Tf
9.1056003571 0 TD
0.0210999995 Tc
[(comprises) -496.3999938965 (b) 3.0999999046 (a) -12.1000003815 (s) 1.1000000238 (es) -496.3999938965 (from) ] TJ
-14.1212997437 -1.2264000177 TD
0.0208000001 Tc
[(positions) -346.299987793 (+) -3.5999999046 (1) 5.9000000954 (,) -4.1999998093 (101) -347 (to) -350.1000061035 (+2,019.) ] TJ
0.8156999946 -1.220600009 TD
0 Tc
[(Fi) 16.3999996185 (ve) -373.5 (po) 15.5 (te) 16.8999996185 (nt) 17.7999992371 (ia) 12.8000001907 (l) -376.3999938965 (h) 0 (o) 19.7000007629 (m) 0 (o) 10.8999996185 (l) 11.1999998093 (og) 15.5 (ue) 16.1000003815 (s) -378.6000061035 (f) 0 (o) 12.6999998093 (r) ] TJ
/F8 1 Tf
12.9180002213 0 TD
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
2.8405001163 0 TD
[(we) 15.8999996185 (re) -369.700012207 (fo) 12.6999998093 (un) 17 (d) -377.200012207 (u) 0 (s) 17.7000007629 (i) 0 (n) 13.6999998093 (g) ] TJ
-16.5741004944 -1.2264000177 TD
[(th) 12.6000003815 (e) -443.8999938965 (h) 0 (u) 17.5 (m) 0 (a) 13.1000003815 (n) ] TJ
/F8 1 Tf
5.0676999092 0 TD
[(IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
2.90989995 0 TD
[(\(N) 17.5 (P_) 17 (78) 16.5 (31) 16.5 (95) 16.5 (\)) -447.3999938965 (a) 0 (n) 15.5 (d) -440.8999938965 (mo) 10.8999996185 (us) 17.7000007629 (e) ] TJ
/F8 1 Tf
10.8642997742 0 TD
-0.0507000014 Tc
[(Tg) -50.7000007629 (7) -37.2000007629 (3) -50.7000007629 (7) ] TJ
/F7 1 Tf
2.9214000702 0 TD
0 Tc
[(\(N) 17.6000003815 (P_) ] TJ
-21.763299942 -1.2264000177 TD
[(03) 16.5 (34) 16.5 (02) 16.5 (\)) -557.299987793 (s) 0 (e) 16.2999992371 (q) 0 (u) 19.1000003815 (e) 0 (n) 15.5 (c) 0 (e) 14.6999998093 (s) 0 (.) -548.200012207 (T) 18.1000003815 (he) -550.799987793 (b) 10.8999996185 (e) 0 (s) 16.2999992371 (t) -557.299987793 (ma) 13.1000003815 (tc) 16.8999996185 (h) -558.200012207 (was) -547.799987793 (GS) 11 (P) 64.5 (A) 65.9000015259 (T) 12.3000001907 (P) 0 (0) 14.8999996185 (0) 0 (0) 16.5 (3) ] TJ
0 -1.220600009 TD
[(85) 16.5 (05) 16.5 (00) 16.5 (1) -385.1000061035 (\() 0 (e) ] TJ
/F12 1 Tf
7.3499999046 0 0 6.5324001312 349.6817932129 509.3290100098 Tm
() Tj
/F7 1 Tf
0.5708000064 0 TD
[(14) 20.3999996185 (6) ] TJ
9.7999000549 0 0 9.7999000549 364.6487121582 504.9637145996 Tm
[(,) -383.6000061035 (3) 0 (8) 16.5 (%) -384.799987793 (id) 15.8000001907 (en) 15.5 (ti) 15.1000003815 (ty) 16.8999996185 (\),) -379.799987793 (wh) 17.3999996185 (i) 11.1999998093 (c) 0 (h) -377.299987793 (c) 0 (o) 12.5 (d) 0 (e) 17.7000007629 (s) -384.3999938965 (fo) 12.6999998093 (r) -382.799987793 (2) 0 (,) 18 (3) 0 (4) 16.5 (1) -385.1000061035 (nu) 17 (-) ] TJ
-6.1147999763 -1.2264000177 TD
[(cl) 18.6000003815 (ei) 12.8000001907 (c) -357.1000061035 (a) 0 (c) 14.6999998093 (i) 11.1999998093 (ds) -350.8999938965 (an) 15.5 (d) -354.1000061035 (7) 0 (4) 16.5 (3) -356.200012207 (am) 18.8999996185 (in) 13.6999998093 (o) -353.5 (a) 0 (c) 14.6999998093 (i) 0 (d) 15.8000001907 (s) 0 (.) -345.799987793 (T) 18.1000003815 (he) -348.3999938965 (RN) 14.5 (Ai) -351 (co) 18.2999992371 (ns) 11.3999996185 (tr) 20.1000003815 (uc) 16.1000003815 (t) -360.6000061035 (f) 13.3000001907 (or) ] TJ
/F8 1 Tf
T*
[(P) 18.2000007629 (a) 0 (r) 26.7000007629 (a) 0 (m) 18.2000007629 (e) 0 (c) 12.1000003815 (i) 0 (u) 17.2999992371 (m) -362.3999938965 (IFT) 12.8000001907 (88) ] TJ
/F7 1 Tf
8.3767004013 0 TD
[(sp) 13.5 (a) 13.1000003815 (n) 0 (s) -358.8999938965 (p) 0 (o) 15.5 (s) 0 (i) 20.2000007629 (t) 0 (i) 15.1000003815 (o) 0 (n) 13.3000001907 (s) -361.299987793 (+4) 18.5 (8) -362 (t) 0 (o) -355.5 (+) 0 (2) 12.8000001907 (,) 0 (1) 18 (2) 0 (1) 16.5 (.) -360.5 (U) 17.3999996185 (s) 0 (i) 14.3999996185 (n) 0 (g) ] TJ
-8.3767004013 -1.220600009 TD
[(a) -299.299987793 (f) 13.3000001907 (ea) 14.6999998093 (tu) 12.6000003815 (re) -288.700012207 (o) 10.8999996185 (f) -299.1000061035 (Pa) 14 (ra) 17.8999996185 (mec) 14.6000003815 (iu) 14.1999998093 (mD) 17.3999996185 (B) -297.8999938965 (t) 0 (o) -291.8999938965 (i) 11.1999998093 (de) 11.8999996185 (nt) 17.7999992371 (i) 11.1999998093 (f) 0 (y) -291.700012207 (p) 0 (o) 15.5 (t) 0 (e) 16.8999996185 (n) 0 (t) 17.7999992371 (i) 0 (a) 12.8000001907 (l) -295.3999938965 (of) 18.3999996185 (f-) 12.8999996185 (ta) 16.8999996185 (rg) 15.1999998093 (et) ] TJ
0 -1.2264000177 TD
[(ef) 14.8999996185 (fec) 10.6000003815 (ts) -386.3999938965 ([) 9.6000003815 (3) 0 (5) 16.5 (]) 0 (,) -374 (w) 0 (e) -383.299987793 (f) 0 (o) 18.3999996185 (u) 0 (n) 17 (d) -388.799987793 (th) 18.3999996185 (at) -376.3999938965 (th) 12.6000003815 (e) ] TJ
/F8 1 Tf
13.1899003983 0 TD
[(MK) 15.8000001907 (S3) ] TJ
/F7 1 Tf
2.9214000702 0 TD
[(RN) 14.5 (Ai) -374.1000061035 (pl) 15.8000001907 (asm) 10.5 (i) 11.1999998093 (d) -388.799987793 (wi) 19.7999992371 (ll) ] TJ
-16.1112995148 -1.2264000177 TD
[(ta) 16.8999996185 (rg) 15.1999998093 (et) -683 (o) 10.8999996185 (n) 0 (l) 13.6999998093 (y) -686.9000244141 (GS) 11 (P) 64.5 (A) 65.9000015259 (TG) 16.6000003815 (00) 16.5 (01) 16.5 (59) 16.5 (39) 16.5 (00) 16.5 (1,) -682 (wh) 17.2999992371 (er) 17.8999996185 (eas) -687.9000244141 (th) 18.3999996185 (e) -692.700012207 (R) 0 (N) 14.5 (A) 0 (i) ] TJ
0 -1.220600009 TD
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9.7999000549 0 0 9.7999000549 56.6929016113 360.9641418457 Tm
[(of) -392.299987793 (th) 18.3999996185 (e) -409.200012207 (ce) 14.6999998093 (nt) 17.7999992371 (ri) 16 (n) -402.5 (st) 18.6000003815 (ai) 18.6000003815 (ni) 13.6999998093 (ng,) -399.700012207 (th) 12.6000003815 (at) -388 (is) -8.6999998093 (,) -395.200012207 (ab) 12.5 (o) 10.8999996185 (ve) -390.8999938965 (th) 12.6000003815 (e) -397.6000061035 (st) 18.6000003815 (ai) 12.8000001907 (ni) 19.3999996185 (ng) -392.1000061035 (of) -392.299987793 (th) 18.3999996185 (e) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 348.945526123 Tm
[(bas) 9.8999996185 (a) 13.1000003815 (l) -312.700012207 (bo) 16 (dy) 11.8999996185 (.) -308.3999938965 (T) 18.1000003815 (he) -302.1000061035 (an) 15.5 (ti) 15.1000003815 (-) 11.1000003815 (ce) 14.6999998093 (nt) 12 (ri) 21.7999992371 (n) -310 (an) 15.5 (ti) 15.1000003815 (bo) 16 (dy) -306.299987793 (rec) 13.6000003815 (og) 15.5 (ni) 19.3999996185 (ze) 10.5 (s) ] TJ
ET
BT
0 TL
/F8 1 Tf
9.7999000549 0 0 9.7999000549 255.9679870605 348.945526123 Tm
[(Te) 15.5 (tr) 25.8999996185 (ah) 14.8999996185 (y-) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 336.926940918 Tm
[(me) 13.1000003815 (na) ] TJ
ET
BT
0 TL
/F7 1 Tf
9.7999000549 0 0 9.7999000549 81.4680328369 336.926940918 Tm
[(ce) 14.6999998093 (nt) 12 (ri) 21.7999992371 (n) -252.1000061035 (1,) -248.1000061035 (wh) 17.3999996185 (ic) 12.8000001907 (h) -251.5 (i) 11.1999998093 (s) -257.1000061035 (ho) 19.7000007629 (mo) 10.8999996185 (l) 11.1999998093 (og) 15.5 (ou) 13.8999996185 (s) -251.3999938965 (to) ] TJ
ET
BT
/F8 1 Tf
9.7999000549 0 0 9.7999000549 219.74168396 336.926940918 Tm
[(P) 18.2000007629 (ar) 26.7000007629 (am) 12.3999996185 (e) 11 (ci) 15.8999996185 (um) ] TJ
ET
BT
/F7 1 Tf
9.7999000549 0 0 9.7999000549 273.0325622559 336.926940918 Tm
[(ce) 14.6999998093 (n-) ] TJ
ET
BT
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6929016113 324.9651794434 Tm
[(tr) 14.3999996185 (i) 11.1999998093 (n) -414.1000061035 (2,) -410.1000061035 (wh) 17.2999992371 (ic) 12.8000001907 (h) -413.5 (i) 11.1999998093 (s) -419.1000061035 (f) 13.3000001907 (ou) 13.8999996185 (nd) -409.5 (i) 11.1999998093 (n) -414.1000061035 (th) 12.6000003815 (e) -415 (bas) 15.6000003815 (al) -409.5 (bo) 16 (dy) -410.3999938965 (al) 18.6000003815 (on) 13.3000001907 (g) -411.8999938965 (th) 12.6000003815 (e) -415 (sh) 17.7000007629 (af) 14.8999996185 (t) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 312.9465942383 Tm
[([) 9.6000003815 (24) 16.5 (].) -408.700012207 (T) 18.1000003815 (he) -412 (tr) 14.3999996185 (an) 15.5 (si) 20.2000007629 (ti) 15.1000003815 (on) -409 (zo) 14 (ne) -406.799987793 (of) -409.6000061035 (th) 12.6000003815 (e) ] TJ
ET
BT
0 TL
/F8 1 Tf
9.7999000549 0 0 9.7999000549 193.0389099121 312.9465942383 Tm
[(P) 18.2000007629 (ar) 26.7000007629 (am) 12.3999996185 (e) 11 (ci) 15.8999996185 (um) ] TJ
ET
BT
/F7 1 Tf
9.7999000549 0 0 9.7999000549 247.9173736572 312.9465942383 Tm
[(ci) 12.8000001907 (l) 11.1999998093 (iu) 14.1999998093 (m) -416.6000061035 (has) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 300.9279785156 Tm
[(be) 12.5 (en) -366.299987793 (de) 17.7000007629 (fi) 13 (ne) 15.5 (d) -371.5 (as) -377.1000061035 (st) 12.8000001907 (re) 17.8999996185 (tc) 16.8999996185 (hi) 14.1999998093 (ng) -380.6000061035 (f) 13.3000001907 (ro) 15.6999998093 (m) -376.1000061035 (th) 12.6000003815 (e) -374.5 (bas) 9.8999996185 (al) -363.200012207 (bo) 16 (dy) 11.8999996185 (,) -372.1000061035 (ne) 15.5 (ar) -369.700012207 (th) 18.3999996185 (e) ] TJ
ET
BT
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6929016113 288.9662475586 Tm
[(pr) 15.1000003815 (o) 10.8999996185 (xi) 14.3000001907 (ma) 13.1000003815 (l) -254.8999938965 (su) 17.7000007629 (rf) 12.3000001907 (a) 13.1000003815 (ce) -251.3999938965 (of) -247.6999969482 (th) 12.6000003815 (e) -253 (ep) 11.8999996185 (i) 11.1999998093 (pl) 15.8000001907 (asm) 10.5 (,) -256.3999938965 (to) -245.6000061035 (th) 12.6000003815 (e) -258.799987793 (b) 10.8999996185 (ase) -254 (o) 10.8999996185 (f) -258.6000061035 (th) 18.3999996185 (e) -270.299987793 (ci) 18.6000003815 (li) 16.7000007629 (um) 14.5 (,) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 276.9476318359 Tm
[(wh) 17.3999996185 (er) 12.1000003815 (e) -409.200012207 (th) 12.6000003815 (e) -409.200012207 (tr) 14.3999996185 (i) 11.1999998093 (pl) 15.8000001907 (ets) -408 (of) -403.8999938965 (mi) 17 (cr) 12.1000003815 (o) 10.8999996185 (tu) 12.6000003815 (b) 10.8999996185 (ul) 14.1999998093 (es) -406 (b) 10.8999996185 (ecom) 19.7000007629 (e) -415 (do) 15.5 (ub) 13.8999996185 (l) 11.1999998093 (ets) -408 (an) 15.5 (d) ] TJ
ET
BT
9.7999000549 0 0 9.7999000549 56.6929016113 264.9290466309 Tm
[(th) 12.6000003815 (e) -472.799987793 (ce) 14.6999998093 (nt) 12 (ra) 17.8999996185 (l) -463.1000061035 (pa) 11.8999996185 (i) 11.1999998093 (r) -469.6000061035 (o) 10.8999996185 (f) -466.799987793 (mi) 17 (cr) 12.1000003815 (o) 10.8999996185 (tu) 12.6000003815 (b) 10.8999996185 (ul) 14.1999998093 (e) -467 (do) 15.5 (ub) 13.8999996185 (l) 11.1999998093 (ets) -465.799987793 (b) 10.8999996185 (eg) 12 (i) 11.1999998093 (ns) -457.200012207 ([) 9.6000003815 (25) 16.5 (,) 3.9000000954 (26) 16.5 (].) ] TJ
ET
BT
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6929016113 252.9672851562 Tm
[(T) 18.1000003815 (he) -296.299987793 (lo) 16.3999996185 (ca) 14.6999998093 (li) 16.7000007629 (zat) 14.3000001907 (io) 10.6000003815 (n) -298.3999938965 (of) -299.700012207 (th) 18.3999996185 (e) -305.1000061035 (MK) 13.6999998093 (S3) -297.3999938965 (pr) 15.1000003815 (o) 10.8999996185 (te) 16.8999996185 (in) -298.700012207 (i) 11.1999998093 (s) -303.3999938965 (th) 12.6000003815 (er) 17.8999996185 (ef) 14.8999996185 (or) 15.6999998093 (e) -316.6000061035 (co) 18.2000007629 (ns) 17.2000007629 (is) 14.3999996185 (t) 27 (-) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6929016113 240.9486846924 Tm
[(en) 15.5 (t) -262.299987793 (wi) 14 (th) -253.5 (th) 18.3999996185 (at) -255 (of) -259.200012207 (th) 18.3999996185 (e) -264.6000061035 (tr) 20.1000003815 (an) 15.5 (si) 14.3999996185 (ti) 15.1000003815 (on) -252.8000030518 (zo) 14 (ne) -256.3999938965 (fo) 18.3999996185 (r) -261.3999938965 (th) 12.6000003815 (es) 16.2999992371 (e) -270.299987793 (ce) 14.6999998093 (ll) 16.7000007629 (s.) ] TJ
ET
BT
9.7999000549 0 0 9.7999000549 64.6866836548 228.9300842285 Tm
[(To) -445.3999938965 (qua) -8.3000001907 (ntify) -447.799987793 (the) -442.8999938965 (ba) -16.5 (sal) -446.799987793 (body) -446.3999938965 (and) -448.5 (FL) -34.5 (AG-MKS3p) -452.5 (stain-) ] TJ
ET
BT
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6929016113 216.9683227539 Tm
[(ing) -22.2000007629 (,) -464.6000061035 (15) ] TJ
ET
BT
0 TL
/F11 1 Tf
9.7999000549 0 0 9.7999000549 90.5946731567 216.9683227539 Tm
[() ] TJ
ET
BT
0.1974000037 Tc
/F7 1 Tf
9.7999000549 0 0 9.7999000549 95.9238586426 216.9683227539 Tm
[<6DD731> 197.3999938965 (5) ] TJ
ET
BT
0 Tc
/F11 1 Tf
9.7999000549 0 0 9.7999000549 128.0116729736 216.9683227539 Tm
[() ] TJ
ET
BT
/F7 1 Tf
9.7999000549 0 0 9.7999000549 133.3408660889 216.9683227539 Tm
[(m) -462.799987793 (square) -10.3000001907 (s) -459.6000061035 (on) -466.799987793 (the) -466 (dorsal) -467.1000061035 (and) -465.799987793 (ventral) ] TJ
ET
BT
-0.0191999003 Tc
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6919212341 204.9497375488 Tm
[(surf) -5.9000000954 (aces) -554 (of) -555.5 (three) -555.700012207 (d) 2.7000000477 (iffe) -6.0999999046 (rent) -547.5999755859 (ce) -6.0999999046 (lls) -554 (e) -0.3000000119 (xpre) -6.0999999046 (ssing) -552.5999755859 (FL) -29.8999996185 (A) -5.4000000954 (G) 2.5 (-) ] TJ
ET
BT
-0.0135000004 Tc
0 TL
/F8 1 Tf
9.7999000549 0 0 9.7999000549 265.9442749023 204.9497375488 Tm
[(MK) 6.0999999046 (S) 6.9000000954 (3) ] TJ
ET
BT
-0.0175000001 Tc
1.2264000177 TL
/F7 1 Tf
9.7999000549 0 0 9.7999000549 56.6919212341 192.931137085 Tm
[(wer) 4.5999999046 (e) -392 (r) 4.5999999046 (a) 1.3999999762 (nd) 4.4000000954 (omly) -386.200012207 (cho) 5 (s) -2.7000000477 (en.) -389.6000061035 (O) -0.1000000015 (f) -386 (t) -2.0999999046 (he) -386.200012207 (463) -385.299987793 (b) -0.8000000119 (a) -17.5 (s) 10.3999996185 (al) -388.1000061035 (bod) 4.4000000954 (ies) -390.299987793 (obser) -30.1000003815 (ved,) ] TJ
ET
BT
-0.0184000004 Tc
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6919212341 180.9693756104 Tm
[(95.2%) -200.6999969482 -199 (2) 1.3999999762 (.2%) -565.200012207 (o) -1.7000000477 (f) -560.4000244141 (t) -3 (hem) -568 (h) 1.8999999762 (ad) -563.4000244141 (FL) -34.9000015259 (AG-) ] TJ
ET
BT
-0.0170000009 Tc
0 TL
/F8 1 Tf
9.7999000549 0 0 9.7999000549 199.1040649414 180.9693756104 Tm
[(MKS3) ] TJ
ET
BT
-0.0185998995 Tc
/F7 1 Tf
9.7999000549 0 0 9.7999000549 228.9810180664 180.9693756104 Tm
[(staining.) -564.200012207 (T) 11.1000003815 (h) -4 (e) 0.3000000119 (se) ] TJ
ET
BT
0.3280999959 Tc
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6919212341 168.9507751465 Tm
[(d) 344.200012207 (a) 347 (t) 349.299987793 (a) -11.6999998093 (s) 342.8999938965 (u) 348.3999938965 (g) 344.299987793 (g) 350.1000061035 (e) 341.200012207 (s) 348.6000061035 (tt) 343.5 (h) 348.3999938965 (a) 341.200012207 (tw) 342.5 (h) 348.3999938965 (e) 347 (r) 344.3999938965 (eab) 344.799987793 (a) 328.1000061035 (s) 356 (a) 341.200012207 (l) 3.7999999523 (b) 344.799987793 (o) 344.799987793 (d) 350 (y) -5.9000000954 (i) 350.8999938965 (sp) 350 (r) 344.3999938965 (e) 347 (s) 348.6000061035 (e) 341.200012207 (n) 347.8999938965 (t) 328.1000061035 (,) 6.0999999046 (w) 348.299987793 (ee) 347 (x) 342.700012207 (p) 344.200012207 (e) 328.1000061035 (c) 354.299987793 (t) ] TJ
ET
BT
-0.0152000003 Tc
9.7999000549 0 0 9.7999000549 56.6919212341 156.9321746826 Tm
[(to) -299.299987793 (f) 3.9000000954 (i) 1.7999999523 (n) 4.5999999046 (d) -305.700012207 (M) 3.5999999046 (K) 2.9000000954 (S) 3.0999999046 (3) -302 (p) 6.6999998093 (r) 1.1000000238 (ot) 6 (ei) 7.5999999046 (n.) -300.5 (To) -299.299987793 (qu) 5.0999999046 (an) 4.5999999046 (t) 6 (i) 1.7999999523 (f) 3.9000000954 (y) -302.8999938965 (th) 5.0999999046 (e) -302.8999938965 (e) 3.7000000477 (xt) 6 (en) 4.5999999046 (t) -300.6000061035 (o) 1.5 (f) -302.700012207 (c) 3.7000000477 (ol) 7.5999999046 (oc) 3.7000000477 (al) 7.5999999046 (iz) -15.1999998093 (a) 6.8000001907 (-) ] TJ
ET
BT
0.0113000004 Tc
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6919212341 144.9704284668 Tm
[(t) 26.7000007629 (i) 34.0999984741 (o) 28 (n) -333.3999938965 (of) -363 (the) -369 (c) -4.5 (entrin) -362.299987793 (and) -360.200012207 (F) -0.8999999762 (L) -34.0999984741 (A) 2 (G-MKS3p) -360.200012207 (s) -2.9000000954 (taining) -24.6000003815 (,) -360.799987793 (the) -363.200012207 (i) -0.6000000238 (m-) ] TJ
ET
BT
0.0109999999 Tc
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6919212341 132.9518280029 Tm
[(ages) -286.6000061035 (we) -4.8000001907 (re) -288.299987793 (ana) -4.8000001907 (l) -0.8999999762 (yze) -4.8000001907 (d) -279.5 (using) -279.3999938965 (s) -3.2000000477 (oftWoR) -11.3999996185 (x) -298.299987793 (s) 2.5999999046 (oftware) -282.5 (t) 3.2999999523 (o) -284.700012207 (obtain) -281.6000061035 (a) ] TJ
ET
BT
-0.0183000006 Tc
9.7999000549 0 0 9.7999000549 56.6919212341 120.9332275391 Tm
[(Pearson) ] TJ
ET
BT
0 Tc
0 TL
/F10 1 Tf
9.7999000549 0 0 9.7999000549 87.7027206421 120.9332275391 Tm
[<92> ] TJ
ET
BT
-0.0184000004 Tc
/F7 1 Tf
9.7999000549 0 0 9.7999000549 88.8365707397 120.9332275391 Tm
[(s) -287.1000061035 (c) 0.5 (oefficient) -286.5 (\() ] TJ
ET
BT
0 Tc
/F8 1 Tf
9.7999000549 0 0 9.7999000549 141.0504455566 120.9332275391 Tm
[(r) ] TJ
ET
BT
-0.0178999994 Tc
/F7 1 Tf
9.7999000549 0 0 9.7999000549 144.5656585693 120.9332275391 Tm
[(\).) -285.799987793 (Ele) -17.8999996185 (v) 7.8000001907 (en) -287.3999938965 (FL) -28.6000003815 (A) -4.0999999046 (G) 3.7999999523 (-MKS3p) -285.200012207 (cells) -286.6000061035 (showed) ] TJ
ET
BT
-0.0185000002 Tc
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6919212341 108.9714736938 Tm
[(an) -415.200012207 (a) 12 (v) -0.200000003 (erage) -421.8999938965 (c) 0.400000006 (olocaliz) -18.5 (a) 9.3000001907 (t) -3.0999999046 (ion) -415.200012207 (s) 2 (c) -5.4000000954 (o) 4 (re) -416.1000061035 (of) -415.8999938965 (0.46) -201.1000061035 -193.3000030518 (0) -4.4000000954 (.11) -415.200012207 (\() ] TJ
ET
BT
0 Tc
0 TL
/F8 1 Tf
9.7999000549 0 0 9.7999000549 245.7055358887 108.9714736938 Tm
[(r) ] TJ
ET
BT
0.1806000024 Tc
/F7 1 Tf
9.7999000549 0 0 9.7999000549 251.0915527344 108.9714736938 Tm
[ 198.8999938965 (D) 198 (\)) 196 (,) -214.6000061035 (i) 197.6000061035 (n) 200.3999938965 (-) ] TJ
ET
BT
-0.0185000002 Tc
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6919212341 96.9528808594 Tm
[(dic) -5.4000000954 (a) 0.400000006 (ting) -586.5999755859 (partial) -585.799987793 (c) 0.400000006 (oloca) -5.4000000954 (l) 4.3000001907 (iz) -18.5 (ation.) -581.5 (FL) -35 (AG-MKS3p) -586.700012207 (staining) -580.799987793 (is) ] TJ
ET
BT
-0.0181000009 Tc
9.7999000549 0 0 9.7999000549 56.6919212341 84.9342803955 Tm
[(clearly) -369.3999938965 (se) -5 (en) -368.6000061035 (in) -368.6000061035 (the) -375.200012207 (o) 4.4000000954 (ral) -371.299987793 (g) -1.8999999762 (roove) -369.3999938965 (\() -2.7000000477 (Figure) -369.3999938965 (1A) -27.3999996185 (,) -372.799987793 (yellow) -368.200012207 (a) -5 (rrows\),) ] TJ
ET
BT
1.220600009 TL
9.7999000549 0 0 9.7999000549 56.6919212341 72.9725189209 Tm
[(but) -355.700012207 (w) -3.7999999523 (e) -352.200012207 (w) -3.7999999523 (er) 3.9000000954 (e) -358 (u) 2.0999999046 (nabl) 4.5999999046 (e) -358 (t) 3 (o) -354.3999938965 (d) -2.0999999046 (ifferentiate) -358 (individual) -354.1000061035 (ba) -18.2000007629 (s) 3.9000000954 (a) 0.6999999881 (l) -354.1000061035 (b) -1.5 (o) 4.3000001907 (d) -2.0999999046 (ies) ] TJ
ET
BT
-0.0184000004 Tc
1.2264000177 TL
9.7999000549 0 0 9.7999000549 56.6919212341 60.953918457 Tm
[(in) -305.200012207 (this) -304.5 (region) -305.200012207 (be) -18.3999996185 (c) 7.8000001907 (a) -5.3000001907 (use) -306.1000061035 (o) -1.7000000477 (f) -305.8999938965 (t) 2.7999999523 (heir) -302.8999938965 (close) -306.1000061035 (p) -2.2999999523 (acking) -303 (a) -5.3000001907 (nd) -303.1000061035 (the) -306.1000061035 (s) 2.0999999046 (patial) ] TJ
ET
BT
-31.8349990845 TL
9.7999000549 0 0 9.7999000549 304.7225036621 372.9337463379 Tm
[(limitations) -587.799987793 (o) -1.6000000238 (f) -583.5 (f) 0.8000000119 (luorescence) -589.5 (microscopy) -5.1999998093 (.) -581.299987793 (T) 5.5999999046 (herefore,) -587.0999755859 (t) 2.9000000954 (hese) ] TJ
ET
BT
-0.0185998995 Tc
1.220600009 TL
9.7999000549 0 0 9.7999000549 304.7225036621 360.9719848633 Tm
[(ora) -5.5 (l) -267.700012207 (groove) -271.6000061035 (b) -1.8999999762 (a) -18.6000003815 (s) 9.3000001907 (al) -273.5 (bodies) -270 (were) -271.6000061035 (not) -275.1000061035 (i) 4.1999998093 (ncluded) -268.6000061035 (i) -1.6000000238 (n) -270.700012207 (o) -1.8999999762 (ur) -268.3999938965 (a) -5.5 (n) 1.2000000477 (alysis.) ] TJ
ET
BT
0 Tc
/F5 1 Tf
9.2000999451 0 0 9.2000999451 304.7243041992 336.9259033203 Tm
[(Ultrastructur) -12.6999998093 (e) ] TJ
ET
BT
/F7 1 Tf
9.7999000549 0 0 9.7999000549 304.7243041992 324.9637145996 Tm
[(We) -382.700012207 (utilize) -388.700012207 (RNAi) -382.799987793 (by) -380.8999938965 (feedin) -11.6999998093 (g) -377.200012207 (of) -380.700012207 (param) -10.8000001907 (e) -10 (cia) -384.799987793 (be) -10.6999998093 (cause) -388.299987793 (of) -380.700012207 (it) -13.8999996185 (s) ] TJ
ET
BT
1.2264000177 TL
9.7999000549 0 0 9.7999000549 304.7243041992 312.945098877 Tm
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BT
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ET
BT
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BT
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BT
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ET
BT
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ET
BT
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[(MKS3) ] TJ
ET
BT
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BT
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ET
BT
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BT
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/EmbeddedDocument /MC3 BDC
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n
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ET
BT
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ET
BT
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ET
BT
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BT
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[(FLAG-) ] TJ
ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
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BT
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ET
BT
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[(Intracellular) ] TJ
ET
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BT
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ET
q
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h
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EMC
EMC
Q
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ET
BT
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ET
BT
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ET
BT
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[(MKS3) ] TJ
ET
BT
/F3 1 Tf
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BT
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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ET
BT
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